| 1. |
- Belfrage, Christina, et al.
(författare)
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Doppler-Free Laser Spectroscopy Measurements on a Ne Discharge for Determination of 22Ne-20Ne Isotope Shifts
- 1983
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Ingår i: Physica Scripta. - : IOP Publishing. - 0031-8949 .- 1402-4896. ; 27:5, s. 357-370
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Tidskriftsartikel (refereegranskat)abstract
- We have used Doppler-free polarization spectroscopy, intermodulated fluorescence and intermodulated optogalvanic spectroscopy for measuring isotope shifts in 6 Ne lines connecting the 2p53s and 2p53p configurations. The measurements were performed on two different hollow cathodes. For the 5852, 5882, 5945, 5976, 6143 and 6164 A lines the 22Ne-20Ne isotope shift was found to be 2300(15), 1740(2), 1717(3), 1728(5), 1669(4) and 1663(5) MHz, respectively. These results are in fair agreement with previous optical spectroscopy data.
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| 2. |
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| 3. |
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| 4. |
- Le Cann, Sophie, et al.
(författare)
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Characterization of the bone-metal implant interface by Digital Volume Correlation of in-situ loading using neutron tomography
- 2017
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Ingår i: Journal of the Mechanical Behavior of Biomedical Materials. - : Elsevier BV. - 1751-6161. ; 75, s. 271-278
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Tidskriftsartikel (refereegranskat)abstract
- Metallic implants are commonly used as surgical treatments for many orthopedic conditions. The long-term stability of implants relies on an adequate integration with the surrounding bone. Unsuccessful integration could lead to implant loosening. By combining mechanical loading with high-resolution 3D imaging methods, followed by image analysis such as Digital Volume Correlation (DVC), we aim at evaluating ex vivo the mechanical resistance of newly formed bone at the interface. X-rays tomography is commonly used to image bone but induces artefacts close to metallic components. Utilizing a different interaction with matter, neutron tomography is a promising alternative but has not yet been used in studies of bone mechanics. This work demonstrates that neutron tomography during in situ loading is a feasible tool to characterize the mechanical response of bone-implant interfaces, especially when combined with DVC. Experiments were performed where metal screws were implanted in rat tibiae during 4 weeks. The screws were pulled-out while the samples were sequentially imaged in situ with neutron tomography. The images were analyzed to quantify bone ingrowth around the implants. DVC was used to track the internal displacements and calculate the strain fields in the bone during loading. The neutron images were free of metal-related artefacts, which enabled accurate quantification of bone ingrowth on the screw (ranging from 60% to 71%). DVC allowed successful identification of the deformation and cracks that occurred during mechanical loading and led to final failure of the bone-implant interface.
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| 5. |
- Nilsson, Magnus, et al.
(författare)
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Discovery of 4 '-azido-2 '-deoxy-2 '-C-methyl cytidine and prodrugs thereof : A potent inhibitor of Hepatitis C virus replication
- 2012
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Ingår i: Bioorganic & Medicinal Chemistry Letters. - : Elsevier BV. - 0960-894X .- 1464-3405. ; 22:9, s. 3265-3268
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Tidskriftsartikel (refereegranskat)abstract
- 4'-Azido-2'-deoxy-2'-methylcytidine (14) is a potent nucleoside inhibitor of the HCV NS5B RNA-dependent RNA polymerase, displaying an EC50 value of 1.2 mu M and showing moderate in vivo bioavailability in rat (F = 14%). Here we describe the synthesis and biological evaluation of 4'-azido-2'-deoxy-2'-methylcytidine and prodrug derivatives thereof. (C) 2012 Elsevier Ltd. All rights reserved.
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| 6. |
- Nilsson, Magnus, et al.
(författare)
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Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease : exploration of P2 quinazoline substituents.
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Novel NS3/4A protease inhibitors comprising quinazoline derivatives as P2 substituent were synthesized. High potency inhibitors displaying advantageous PK properties have been obtained through the optimization of quinazoline P2 substituents in three series of macrocyclic P2 cyclopentane dicarboxylic acid and P2 proline urea motifs. For the quinazoline moiety it was found that 8-methyl substitution for the P2 cyclopentane dicarboxylic acid series improved on the stability in human liver microsomes. By comparison, the proline urea series displayed advantageous Caco-2 permeability over the cyclopentane series. properties were assessed in rat on selected compounds. Excellent exposure and liver–to-plasma ratios were demonstrated for a member of the 14-membered quinazoline substituted P2 proline urea series. In vivo pharmacokinetic properties were assessed in rat on selected compounds. Excellent exposure and liver–to-plasma ratios were demonstrated for a member of the 14-membered quinazoline substituted P2 proline urea series.
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| 7. |
- Nilsson, Magnus, et al.
(författare)
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Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease : Exploration of P2 quinazoline substituents
- 2010
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Ingår i: Bioorganic & Medicinal Chemistry Letters. - : Elsevier BV. - 0960-894X .- 1464-3405. ; 20:14, s. 4004-4011
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Tidskriftsartikel (refereegranskat)abstract
- Novel NS3/4A protease inhibitors comprising quinazoline derivatives as P2 substituent were synthesized. High potency inhibitors displaying advantageous PK properties have been obtained through the optimization of quinazoline P2 substituents in three series exhibiting macrocyclic P2 cyclopentane dicarboxylic acid and P2 proline urea motifs. For the quinazoline moiety it was found that 8-methyl substitution in the P2 cyclopentane dicarboxylic acid series improved on the metabolic stability in human liver microsomes. By comparison, the proline urea series displayed advantageous Caco-2 permeability over the cyclopentane series. Pharmacokinetic properties in vivo were assessed in rat on selected compounds, where excellent exposure and liver-to-plasma ratios were demonstrated for a member of the 14-membered quinazoline substituted P2 proline urea series. (C) 2010 Elsevier Ltd. All rights reserved.
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| 8. |
- Wallerstedt, Susanna Maria, 1970, et al.
(författare)
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[Many patients with suboptimal drug treatment are missed. Sensitivity, specificity and prediction value of drug-specific quality indicators for the elderly]. : Många patienter med suboptimal läkemedelsbehandling missas - Sensitivitet, specificitet och prediktionsvärde hos läkemedelsspecifika kvalitetsindikatorer för äldre.
- 2016
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Ingår i: Läkartidningen. - 1652-7518. ; 113
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Tidskriftsartikel (refereegranskat)abstract
- This study aimed to evaluate the concurrent validity of drug-specific indicators of prescribing quality developed by the National Board of Health and Welfare. In 200 hip fracture patients, quality of drug treatment was assessed according to a gold standard as well as to Swedish drug-specific indicators. As gold standard, two specialist physicians independently assessed and then agreed on the quality of treatment, after initial systematic assessments with explicit screening tools. According to the indicators and the gold standard, 82 (41%) 141 (71%) patients had inappropriate drug treatment. The sensitivity for individual indicators ranged from 0.02 to 0.32, and the specificity from 0.90 to 1.00.
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