| 1. |
- Chincarini, Andrea, et al.
(författare)
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Automatic temporal lobe atrophy assessment in prodromal AD: Data from the DESCRIPA study
- 2014
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Ingår i: Alzheimer's & Dementia. - : Wiley. - 1552-5279 .- 1552-5260. ; 10:4, s. 456-467
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Tidskriftsartikel (refereegranskat)abstract
- Background: In the framework of the clinical validation of research tools, this investigation presents a validation study of an automatic medial temporal lobe atrophy measure that is applied to a naturalistic population sampled from memory clinic patients across Europe. Methods: The procedure was developed on 1.5-T magnetic resonance images from the Alzheimer's Disease Neuroimaging Initiative database, and it was validated on an independent data set coming from the DESCRIPA study. All images underwent an automatic processing procedure to assess tissue atrophy that was targeted at the hippocampal region. For each subject, the procedure returns a classification index. Once provided with the clinical assessment at baseline and follow-up, subjects were grouped into cohorts to assess classification performance. Each cohort was divided into converters (co) and nonconverters (nc) depending on the clinical outcome at follow-up visit. Results: We found the area under the receiver operating characteristic curve (AUC) was 0.81 for all co versus nc subjects, and AUC was 0.90 for subjective memory complaint (SMCnc) versus all co subjects. Furthermore, when training on mild cognitive impairment (MCI-nc/MCI-co), the classification performance generally exceeds that found when training on controls versus Alzheimer's disease (CTRL/AD). Conclusions: Automatic magnetic resonance imaging analysis may assist clinical classification of subjects in a memory clinic setting even when images are not specifically acquired for automatic analysis. (C) 2014 The Alzheimer's Association. All rights reserved.
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| 2. |
- Ciuni, Roberto, et al.
(författare)
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Future contingents, Supervaluationism, and relative truth
- 2019
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Ingår i: Third Pisa Colloquium in Logic, Language and Epistemology : Essays in honour of Mauro Mariani and Carlo Marletti - Essays in honour of Mauro Mariani and Carlo Marletti. - 9788846755193 ; , s. 69-88
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The problem of future contingents is one of the most ancient and debated puzzles in Western philosophy, and Supervaluationism is, today, one of the most prominent solutions to the problem. Recently, John MacFarlane has carried a well-known criticism to Supervaluationism (and all other standard approaches to future contingents) and put forward a new solution of the problem of future contingents, which is known as Double Time Reference Theory (DTRT). Here, we compare DTRT with Supervaluationist semantics, and we show that the success of MacFarlane's criticism crucially depends on the expressivity of the language adopted. Once a reasonable expressive power is granted, however, MacFarlane's criticism no longer applies.
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