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- Gianfrancesco, MA, et al.
(författare)
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Genetic risk factors for pediatric-onset multiple sclerosis
- 2018
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Ingår i: Multiple sclerosis (Houndmills, Basingstoke, England). - : SAGE Publications. - 1477-0970 .- 1352-4585. ; 24:14, s. 1825-1834
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Tidskriftsartikel (refereegranskat)abstract
- Strong evidence supports the role of both genetic and environmental factors in pediatric-onset multiple sclerosis (POMS) etiology. Objective: We comprehensively investigated the association between established major histocompatibility complex (MHC) and non-MHC adult multiple sclerosis (MS)-associated variants and susceptibility to POMS. Methods: Cases with onset <18 years ( n = 569) and controls ( n = 16,251) were included from the United States and Sweden. Adjusted logistic regression and meta-analyses were performed for individual risk variants and a weighted genetic risk score (wGRS) for non-MHC variants. Results were compared to adult MS cases ( n = 7588). Results: HLA–DRB1*15:01 was strongly associated with POMS (odds ratio (OR)meta = 2.95, p < 2.0 × 10−16). Furthermore, 28 of 104 non-MHC variants studied (23%) were associated ( p < 0.05); POMS cases carried, on average, a higher burden of these 28 variants compared to adults (ORavg = 1.24 vs 1.13, respectively), though the difference was not significant. The wGRS was strongly associated with POMS (ORmeta = 2.77, 95% confidence interval: 2.33, 3.32, p < 2.0 × 10−16) and higher, on average, when compared to adult cases. Additional class III risk variants in the MHC region associated with POMS were revealed after accounting for HLA–DRB1*15:01 and HLA–A*02. Conclusion: Pediatric and adult MS share many genetic variants suggesting similar biological processes are present. MHC variants beyond HLA–DRB1*15:01 and HLA–A*02 are also associated with POMS.
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- Belman-Flores, J. M., et al.
(författare)
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Experimental study of R1234yf as a drop-in replacement for R134a in a domestic refrigerator
- 2017
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Ingår i: International journal of refrigeration. - : ELSEVIER SCI LTD. - 0140-7007 .- 1879-2081. ; 81, s. 1-11
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents an experimental study for three identical domestic refrigerators using R1234yf as a drop-in replacement for R134a. An alternative methodology was proposed to estimate the optimal mass charge for R1234yf; with the use of such methodology, new evidences were sought on the thermal behavior of the refrigerator compartments as well as at the heat exchangers. Additionally, energy performance for both refrigerants was measured, and, finally, a TEWI analysis was conducted. For the type of refrigerator evaluated, results showed that R1234yf presented an average (for the 3 refrigerators) of 0.4 degrees C for the fresh food compartment, and 1.2 degrees C for the freezer, among different charges with respect to R134a. The optimal charge for R1234yf was 92.2 g, which is about 7.8% lower than the one for R134a, which represents a small increase of 4% in energy consumption in comparison to R134a. Finally, the TEWI analysis for the R1234yf was 1.07% higher than the R134a.
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- Belman-Flores, J. M., et al.
(författare)
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Using ANNs to approach to the energy performance for a small refrigeration system working with R134a and two alternative lower GWP mixtures
- 2017
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Ingår i: Applied Thermal Engineering. - : Elsevier Ltd. - 1359-4311 .- 1873-5606. ; 127, s. 996-1004
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, an artificial neural network application to model a small refrigeration system is presented. The main objective of this study is an energy comparison of three refrigerants: R134a, R450A and R513A. The application of the artificial neural network was designed to model individually three typical energy parameters: the cooling capacity, the power consumption and the coefficient of performance, as a function of the evaporating temperature and the condensing temperature. Each model was validated using a technique called cross-validation, producing minimum relative errors of 0.15 for the cooling capacity and the coefficient of performance, while 0.05 for the power consumption. Based on the appropriate validation results, computer simulations were performed to build 3D color surfaces. After inspecting these 3D color surfaces, it was concluded that R450A presented a slightly lower cooling capacity than R134a, actually a 10% reduction in the cooling capacity was estimated. Similar results were observed for the power consumption, that is, R450A had about 10% less power consumption than the other two refrigerants. On the other hand, it was observed that R134a and R513A presented very similar energy behaviors. With respect the COP, it was concluded that all three refrigerants showed a very similar behavior. After the analysis performed with the artificial neural networks and the use of 3D surface color, it was concluded that R450A and R513A are appropriate refrigerants to replace R134a in the short term in applications at medium evaporating temperature.
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- Halperin, J J, et al.
(författare)
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Practice parameter: treatment of nervous system Lyme disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology.
- 2007
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Ingår i: Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 1526-632X .- 0028-3878. ; 69:1, s. 91-102
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To provide evidence-based recommendations on the treatment of nervous system Lyme disease and post-Lyme syndrome. Three questions were addressed: 1) Which antimicrobial agents are effective? 2) Are different regimens preferred for different manifestations of nervous system Lyme disease? 3) What duration of therapy is needed? METHODS: The authors analyzed published studies (1983-2003) using a structured review process to classify the evidence related to the questions posed. RESULTS: The panel reviewed 353 abstracts which yielded 112 potentially relevant articles that were reviewed, from which 37 articles were identified that were included in the analysis. CONCLUSIONS: There are sufficient data to conclude that, in both adults and children, this nervous system infection responds well to penicillin, ceftriaxone, cefotaxime, and doxycycline (Level B recommendation). Although most studies have used parenteral regimens for neuroborreliosis, several European studies support use of oral doxycycline in adults with meningitis, cranial neuritis, and radiculitis (Level B), reserving parenteral regimens for patients with parenchymal CNS involvement, other severe neurologic symptomatology, or failure to respond to oral regimens. The number of children (> or =8 years of age) enrolled in rigorous studies of oral vs parenteral regimens has been smaller, making conclusions less statistically compelling. However, all available data indicate results are comparable to those observed in adults. In contrast, there is no compelling evidence that prolonged treatment with antibiotics has any beneficial effect in post-Lyme syndrome (Level A).
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- Mota-Babiloni, A., et al.
(författare)
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Experimental exergy analysis of R513A to replace R134a in a small capacity refrigeration system
- 2018
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Ingår i: Energy. - : Elsevier Ltd. - 0360-5442 .- 1873-6785. ; 162, s. 99-110
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Tidskriftsartikel (refereegranskat)abstract
- The replacement of HFCs using lower GWP refrigerants in the coming years is a priority to reduce the predicted climate change. The exergy analysis of vapor compression systems can help to identify the feasibility of alternative fluids in existing installations and the potential to improve them. In this sense, this paper presents an exergy analysis of an experimental setup which operates with R134a and the alternative HFO/HFC mixture R513A. The evaporating temperature is ranges between −15 °C and 5 °C, while the condensing temperature is set at 30 °C and 35 °C. In this analysis, the highest amount of exergy destruction rate is obtained at the compressor, followed by the evaporator. The maximum exergy efficiencies are observed at the condenser and the thermostatic expansion device. Finally, the average global exergy efficiency of R513A when replaced R134a in this refrigeration experimental setup is 0.4% higher (absolute difference), and with respect to the components, there is only slight reduction in efficiency in the condenser using R513A. Therefore, the R513A replacement is acceptable according to the second law of thermodynamics.
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