| 1. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 2. |
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| 3. |
- Carvalho, E. de, et al.
(författare)
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EU FP7 INFSO-ICT-317669 METIS, D3.1 Positioning of multi-node/multi-antenna technologies
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This document describes the research activity in multi-node/multi-antenna technologies within METIS and positions it with respect to the state-of-the-art in the academic literature and in the standardization bodies. Based on the state-of-the-art and as well as on the METIS objectives,we set the research objectives and we group the different activities (or technology components) into research clusters with similar research objectives. The technologycomponents and the research objectives have been set to achieve an ambidextrous purpose. On one side we aim at providing the METIS system with those technological components that are a natural but non-trivial evolution of 4G. On the other side, we aim at seeking for disruptivetechnologies that could radically change 5G with respect to 4G. Moreover, we mapped the different technology components to METIS’ other activities and to the overall goals of theproject.
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| 4. |
- Fodor, G., et al.
(författare)
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An Overview of Device-to-Device Communications Technology Components in METIS
- 2016
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Ingår i: IEEE Access. - : Institute of Electrical and Electronics Engineers (IEEE). - 2169-3536 .- 2169-3536. ; 4, s. 3288-3299
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Tidskriftsartikel (refereegranskat)abstract
- As the standardization of network-assisted device-to-device (D2D) communications by the Third Generation Partnership Project progresses, the research community has started to explore the technology potential of new advanced features that will largely impact the performance of 5G networks. For 5G, D2D is becoming an integrative term of emerging technologies that take an advantage of the proximity of communicating entities in licensed and unlicensed spectra. The European 5G research project Mobile and Wireless Communication Enablers for the 2020 Information Society (METIS) has identified advanced D2D as a key enabler for a variety of 5G services, including cellular coverage extension, social proximity, and communicating vehicles. In this paper, we review the METIS D2D technology components in three key areas of proximal communications-network-assisted multi-hop, full-duplex, and multi-antenna D2D communications-and argue that the advantages of properly combining cellular and ad hoc technologies help to meet the challenges of the information society beyond 2020.
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| 5. |
- Malik, J. S., et al.
(författare)
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Improving performance of fading channel simulators by use of Uniformly distributed Random Numbers
- 2011
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Ingår i: 2010 IEEE International Symposium on Signal Processing and Information Technology. - 9781424499908 ; , s. 91-96
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Konferensbidrag (refereegranskat)abstract
- Filter-based fading channel simulators universally use White Gaussian Noise (WGN) to generate complex tap coefficients. In this work, we will show that replacing WGN source by Uniform Random Number Generator (URNG) results in improved simulation speed in case of software simulator; and reduced area/power in case of hardware simulator. We will verify, both analytically and through extensive simulations, that use of URNG does not cause any degradation in important simulator performance parameters like statistical properties, spectral shape, level crossing rate and bit error rate. To validate our analysis, we have designed fading channel simulators both in software and hardware. We will show that use of URNG causes 6 percent improvement in simulation time in case of software simulator. Similarly, we will demonstrate that for a hardware simulator, we obtain an improvement of 30 and 40 percent in area and power consumption respectively.
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| 6. |
- Jie, Xu, et al.
(författare)
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Energy efficient downlink MIMO transmission with linear precoding
- 2013
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Ingår i: Science China Information Sciences. - : Springer Science and Business Media LLC. - 1674-733X .- 1869-1919. ; 56:2, s. 022309-
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Tidskriftsartikel (refereegranskat)abstract
- Energy efficiency (EE) is becoming increasingly important for wireless cellular networks. This paper addresses EE optimization problems in downlink multiuser MIMO systems with linear precoding. Referring to different active transmit/receive antenna sets and transmission schemes as different modes, we propose a joint bandwidth/power optimization and mode switching scheme to maximize EE. With a specific mode, we prove that the optimal bandwidth and transmit power is either full transmit power or full bandwidth. After deriving the optimal bandwidth and transmit power, we further propose mode switching to select the mode with optimal EE. Since the optimal mode switching, i.e. exhaustive search, is too complex to implement, an alternative heuristic method is developed to decrease the complexity through reducing the search size and avoiding the EE calculation during each search. Through simulations, we demonstrate that the proposed methods can significantly improve EE and the performance is similar to the optimal exhaustive search.
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| 7. |
- Shalmashi, Serveh
(författare)
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Cooperative Spectrum Sharing and Device-to-Device Communications
- 2014
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The steep growth in the mobile data traffic has gained a lot of attention in recent years. This growth is mainly the result of emerging applications, multimedia services, and revolutions in the device technology. With current deployments and radio resources, operators will not be able to cope with the growing demands. Consequently, there is a need to either provide new resources or increase the efficiency of what is available. Proposed solutions for accommodating growing data traffic are based on improvements in three dimensions: efficient use of radio resources especially the spectrum, technology advancements, and densifying the current infrastructure. In this thesis, we focus on the spectrum dimension. Providing more spectrum is a long-term process. However, increasing the spectrum usage and efficiency can be put rapidly in practice. We discuss potential solutions in the area of spectrum sharing. Among enabling technologies to facilitate spectrum sharing, we consider the cognitive radio and device-to-device (D2D) communications.In order to gain from sharing the spectrum, systems need to somehow deal with extra sources of interference. In the first part of the thesis, we consider a primary-secondary sharing model in cognitive radio networks. We employ the cooperative communication method in order to facilitate the access of the secondary system to the licensed spectrum of the primary system, and therefore increase the spectrum usage. The cooperation between the two systems is formed provided that it is beneficial for the primary system. In this way, the primary users' quality-of-service can be preserved while at the same time the secondary users can access the spectrum. This cooperative approach prevents both systems from concurrent transmissions. As a consequence, the need for interference control techniques are eliminated. We evaluate different models and transmission schemes and optimize the corresponding parameters to quantify the gain resulting from cooperative spectrum sharing.In the second part of the thesis, we consider spectrum sharing within one system between different types of users. This is done in the context of D2D communications where close proximity users can transmit directly to each other. For this type of communications, either dedicated resources are allocated or resources of the cellular users are reused. We first study the feasibility of cooperation between D2D and cellular users and identify the scenarios where it can be beneficial. Then we take on a challenging problem which guarantees the gain from the D2D communication, namely the mode selection. For this problem, we characterize the decision criteria that determines if D2D communication is gainful. Next, we focus on the problem of interference in D2D communications underlaying cellular networks, where the same spectrum is reused in the spatial domain. In such scenarios, the potential gain is determined by how the interference is managed, which in turn depends on the amount of available information at the base station. The more information is required, the more signaling is needed. In this part of the thesis, we address the trade-off between the signaling overhead and the performance of the system and propose a novel approach for interference control which requires very little information on the D2D users.
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