| 1. |
- Bansal, Sheel, et al.
(författare)
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Practical Guide to Measuring Wetland Carbon Pools and Fluxes
- 2023
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Ingår i: Wetlands (Wilmington, N.C.). - : SPRINGER. - 0277-5212 .- 1943-6246. ; 43:8
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Forskningsöversikt (refereegranskat)abstract
- Wetlands cover a small portion of the world, but have disproportionate influence on global carbon (C) sequestration, carbon dioxide and methane emissions, and aquatic C fluxes. However, the underlying biogeochemical processes that affect wetland C pools and fluxes are complex and dynamic, making measurements of wetland C challenging. Over decades of research, many observational, experimental, and analytical approaches have been developed to understand and quantify pools and fluxes of wetland C. Sampling approaches range in their representation of wetland C from short to long timeframes and local to landscape spatial scales. This review summarizes common and cutting-edge methodological approaches for quantifying wetland C pools and fluxes. We first define each of the major C pools and fluxes and provide rationale for their importance to wetland C dynamics. For each approach, we clarify what component of wetland C is measured and its spatial and temporal representativeness and constraints. We describe practical considerations for each approach, such as where and when an approach is typically used, who can conduct the measurements (expertise, training requirements), and how approaches are conducted, including considerations on equipment complexity and costs. Finally, we review key covariates and ancillary measurements that enhance the interpretation of findings and facilitate model development. The protocols that we describe to measure soil, water, vegetation, and gases are also relevant for related disciplines such as ecology. Improved quality and consistency of data collection and reporting across studies will help reduce global uncertainties and develop management strategies to use wetlands as nature-based climate solutions.
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| 2. |
- Huyghe, Jeroen R., et al.
(författare)
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Discovery of common and rare genetic risk variants for colorectal cancer
- 2019
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:1, s. 76-
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Tidskriftsartikel (refereegranskat)abstract
- To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P < 5 x 10(-8), bringing the number of known independent signals for CRC to similar to 100. New signals implicate lower-frequency variants, Kruppel-like factors, Hedgehog signaling, Hippo-YAP signaling, long noncoding RNAs and somatic drivers, and support a role for immune function. Heritability analyses suggest that CRC risk is highly polygenic, and larger, more comprehensive studies enabling rare variant analysis will improve understanding of biology underlying this risk and influence personalized screening strategies and drug development.
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| 3. |
- Sampson, Joshua N., et al.
(författare)
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Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
- 2015
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 107:12
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Tidskriftsartikel (refereegranskat)abstract
- Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.
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| 4. |
- Wang, Zhaoming, et al.
(författare)
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Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
- 2014
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:24, s. 6616-6633
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.
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| 5. |
- Ahlberg, Jörgen, 1971-, et al.
(författare)
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Evaluating Template Rescaling in Short-Term Single-Object Tracking
- 2015
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Konferensbidrag (refereegranskat)abstract
- In recent years, short-term single-object tracking has emerged has a popular research topic, as it constitutes the core of more general tracking systems. Many such tracking methods are based on matching a part of the image with a template that is learnt online and represented by, for example, a correlation filter or a distribution field. In order for such a tracker to be able to not only find the position, but also the scale, of the tracked object in the next frame, some kind of scale estimation step is needed. This step is sometimes separate from the position estimation step, but is nevertheless jointly evaluated in de facto benchmarks. However, for practical as well as scientific reasons, the scale estimation step should be evaluated separately – for example,theremightincertainsituationsbeothermethodsmore suitable for the task. In this paper, we describe an evaluation method for scale estimation in template-based short-term single-object tracking, and evaluate two state-of-the-art tracking methods where estimation of scale and position are separable.
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| 6. |
- Ahlberg, Jörgen, 1971-, et al.
(författare)
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Multi-person fever screening using a thermal and a visual camera
- 2015
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- We propose a system to automatically measure the body temperature of persons as they pass. In contrast to exisitng systems, the persons do not need to stop and look into a camera one-by-one. Instead, their eye corners are automatically detected and the temperatures therein measured using a thermal camera. The system handles multiple simultaneous persons and can thus be used where a flow of people pass, such as at airport gates.
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| 7. |
- Athanasopoulos, Andreas, et al.
(författare)
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Approximate Inference for the Bayesian Fairness Framework
- 2023
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Ingår i: CEUR Workshop Proceedings. - 1613-0073. ; 3442
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Konferensbidrag (refereegranskat)abstract
- As the impact of Artificial Intelligence systems and applications on everyday life increases, algorithmic fairness undoubtedly constitutes one of the major problems in our modern society. In the current paper, we extend the work of Dimitrakakis et al. on Bayesian fairness [1] that incorporates models uncertainty to achieve fairness, proposing a practical algorithm with the aim to scale the framework for a broader range of applications. We begin by applying the bootstrap technique as a scalable alternative to approximate the posterior distribution of parameters of the fully Bayesian viewpoint. To make the Bayesian fairness framework applicable to more general data settings, we define an empirical formulation suitable for the continuous case. We experimentally demonstrate the potential of the framework from an extensive evaluation study on a real dataset and different decision settings.
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| 8. |
- Bean, Christopher, 1990-, et al.
(författare)
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Short sleep, psychosocial work stressors, and measures of obesity: results from an Australian cohort study
- 2019
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Konferensbidrag (refereegranskat)abstract
- Introduction: Short sleep and workplace stress are both established risk factors for overweight and obesity, yet few studies have considered how these two factors may intersect. The aim of this study was to establish the associations between these two exposures and their relative associations with body mass index (kg/m2 ) and waist circumference (cm).Methods: A cross-sectional design sampled current employees (N=423) from an Australian cohort using a computer-assisted telephone interview and clinic-measured height, weight, and waist circumference. Short sleep (≤6h/ night) was reported by 25.8% of the participants. Psychosocial work stressors were defined using the Job Demand-ControlSupport (JDCS) model and calculated at the subscale level (psychological demands; skill discretion; decision authority; coworker support; supervisor support). General linear models were used to assess associations between short sleep, the JDCS subscales (split at median), and BMI and waist circumference.Results: Separate analyses identified short sleep and a lack of skill discretion at work as predictors of both BMI and waist circumference. Furthermore, when both predictors were entered in the same model, each was associated with elevated BMI (b=1.79, p=.003; b=1.08, p=.045) and waist circumference (b=4.20, p=.005; b=2.97, p=.028). Short sleep was also associated with high perceived psychological demands at work (b=1.81, p=.003). All models were adjusted for gender, age, work hours, blue vs. white collar job, and household income.Discussion: These findings indicate the importance of considering the interplay between short sleep and psychosocial work stressors, and their respective associations with measures of overweight Sleep Sci. 2019;12(Supl.3):1-75 26 and obesity. Further research using longitudinal data is needed to model potential mechanisms (e.g., behavioral and physiological). A novel feature was the subscale consideration of the prominent JDCS model of work stress. Advocacy for both improved habitual sleep (e.g., ≥7h/night) and job redesign to increase skill discretion at work may promote lower levels of overweight and obesity for employees.
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| 9. |
- Berg, Amanda, 1988-, et al.
(författare)
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A thermal infrared dataset for evaluation of short-term tracking methods
- 2015
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- During recent years, thermal cameras have decreased in both size and cost while improving image quality. The area of use for such cameras has expanded with many exciting applications, many of which require tracking of objects. While being subject to extensive research in the visual domain, tracking in thermal imagery has historically been of interest mainly for military purposes. The available thermal infrared datasets for evaluating methods addressing these problems are few and the ones that do are not challenging enough for today’s tracking algorithms. Therefore, we hereby propose a thermal infrared dataset for evaluation of short-term tracking methods. The dataset consists of 20 sequences which have been collected from multiple sources and the data format used is in accordance with the Visual Object Tracking (VOT) Challenge.
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| 10. |
- Berg, Amanda, 1988-, et al.
(författare)
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A Thermal Object Tracking Benchmark
- 2015
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Konferensbidrag (refereegranskat)abstract
- Short-term single-object (STSO) tracking in thermal images is a challenging problem relevant in a growing number of applications. In order to evaluate STSO tracking algorithms on visual imagery, there are de facto standard benchmarks. However, we argue that tracking in thermal imagery is different than in visual imagery, and that a separate benchmark is needed. The available thermal infrared datasets are few and the existing ones are not challenging for modern tracking algorithms. Therefore, we hereby propose a thermal infrared benchmark according to the Visual Object Tracking (VOT) protocol for evaluation of STSO tracking methods. The benchmark includes the new LTIR dataset containing 20 thermal image sequences which have been collected from multiple sources and annotated in the format used in the VOT Challenge. In addition, we show that the ranking of different tracking principles differ between the visual and thermal benchmarks, confirming the need for the new benchmark.
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