| 1. |
- Ntalla, Ioanna, et al.
(författare)
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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
- 2020
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N=293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highlighting key regulation processes for atrioventricular conduction. Additionally, 8 loci not previously reported harbor genes underlying inherited arrhythmic syndromes and/or cardiomyopathies suggesting a role for these genes in cardiovascular pathology in the general population. We show that polygenic predisposition to PR interval duration is an endophenotype for cardiovascular disease, including distal conduction disease, AF, and atrioventricular pre-excitation. These findings advance our understanding of the polygenic basis of cardiac conduction, and the genetic relationship between PR interval duration and cardiovascular disease. On the electrocardiogram, the PR interval reflects conduction from the atria to ventricles and also serves as risk indicator of cardiovascular morbidity and mortality. Here, the authors perform genome-wide meta-analyses for PR interval in multiple ancestries and identify 141 previously unreported genetic loci.
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| 2. |
- van de Vegte, Yordi, et al.
(författare)
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Genetic insights into resting heart rate and its role in cardiovascular disease
- 2023
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- The genetics and clinical consequences of resting heart rate (RHR) remain incompletely understood. Here, the authors discover new genetic variants associated with RHR and find that higher genetically predicted RHR decreases risk of atrial fibrillation and ischemic stroke. Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals 493 independent genetic variants in 352 loci, including 68 genetic variants outside previously identified resting heart rate associated loci. We prioritize 670 genes and in silico annotations point to their enrichment in cardiomyocytes and provide insights in their ECG signature. Two-sample Mendelian randomization analyses indicate that higher genetically predicted resting heart rate increases risk of dilated cardiomyopathy, but decreases risk of developing atrial fibrillation, ischemic stroke, and cardio-embolic stroke. We do not find evidence for a linear or non-linear genetic association between resting heart rate and all-cause mortality in contrast to our previous Mendelian randomization study. Systematic alteration of key differences between the current and previous Mendelian randomization study indicates that the most likely cause of the discrepancy between these studies arises from false positive findings in previous one-sample MR analyses caused by weak-instrument bias at lower P-value thresholds. The results extend our understanding of resting heart rate biology and give additional insights in its role in cardiovascular disease development.
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| 3. |
- Berg, Daniel, 1971-
(kompositör, creator_code:cre_t)
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3' 44¨
- 2019
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Konstnärligt arbete (refereegranskat)abstract
- ” Music is everywhere, you just have to have the ears to hear it” John CageIn 1952, composer John Cage shook the classical music scene when he composed4 ' 33' '. The work, in three movements contained only pauses…Daniel Berg has, with inspiration from Cage, composed the piece 3 '44' for speech choir that contains the word silence in all European languages and all got their unique rhythm.The low-key work ends with the choir blinding and without conductor creates a long diminuendo with exhale and exhale.Duration: 3’ 44’’
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| 4. |
- Berg, Daniel, 1971
(författare)
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3' 44¨
- 2018
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- ” Music is everywhere, you just have to have the ears to hear it” John Cage In 1952, composer John Cage shook the classical music scene when he composed 4 ' 33' '. The work, in three movements contained only pauses… Daniel Berg has, with inspiration from Cage, composed the piece 3 '44' for speech choir that contains the word silence in all European languages and all got their unique rhythm. The low-key work ends with the choir blinding and without conductor creates a long diminuendo with exhale and exhale. Duration: 3’ 44’’
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| 5. |
- Berg, Daniel, 1971-
(kompositör, creator_code:cre_t)
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5 Funny Pieces : for the young choir
- 2017
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Konstnärligt arbete (swepub:mat_score_t) (refereegranskat)abstract
- The famous percussion group, Rhythm Art Duo (Daniel Berg and Fredrik Duvling) encourage young people to start playing classical percussion and they have written a lot of education material. In 5 funny pieces Rhythm Art Duo uses a lot of humor for the young choir. Bosh and Tosh for speech choir, Song for christmas carol with tuned bottles, Body Rhythm for body percussion, A piece of Paper for a choir who makes sounds with papers and Let it Bee! for a speech choir with kazoos…
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| 6. |
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| 7. |
- Berg, Daniel, 1971
(författare)
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Across Heaven - beyond the Clouds
- 2023
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Ingår i: Köpenhamn, Edition Svitzer, oktober 2023.
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- In 1962, the Swedish poet and Nobel laureate Tomas Tranströmer published his collection of poems the Half-Finished Heaven. Here there is both uncertainty and a quiet melancholy about opportunities we never see and take, but at the same time a simple joy and an obvious sense of freedom expressed in heartbreaking images and an incredible linguistic tension. When the artist Peter Christensson heard Daniel's new work for vibraphone and organ, he saw a green sky envisioned, but what’s behind the clouds? This is precisely what is central to art, poetry and music – to describe and portray the unpredictable and enigmatic – a quiet sadness over opportunities we never see and take, but at the same time a joy and obvious sense of freedom expressed in creation.
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| 8. |
- Berg, Daniel, 1971
(författare)
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Arctic Nights
- 2023
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Ingår i: Copenhagen, Edition Svitzer, spring 23.
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- My good friend, the artist Peter Christensson, one day showed me some of his new artwork. The pictures were abstract but got the form of early expeditions to the Arctic. Peter told me, everything started with a dream about a polar swimmer and the world this person met on his journey to the North Pole. With my music, I want to enhance mood, pulse, nuances in the art and poetry of Peter Christensson. The irregular rhythm reinforces the feeling of unease, and the music ultimately aims upwards in the harmonics – a symbol for survival. At horizon or below, a poem begins.
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| 9. |
- Berg, Daniel, 1971-
(creator_code:cre_t, kompositör)
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Bird of Prey : for Piccola and Marimba
- 2022
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Konstnärligt arbete (swepub:mat_score_t) (refereegranskat)abstract
- During the years, I had the opportunity to work together with many excellent flute players and I really think the combination of Flute and Percussion is a perfect match. A lot of great composers have written for the instruments and through them, I got the inspiration to compose for flute and percussion. After composing Dark Shadows, Kinkaku-ji and Second Concerto for Flute & Percussion, all published by Edition Svitzer, I’ve got a question and wish from many flute players to also write something for piccolo and percussion. They are right, there are not so many pieces composed for that combination of instruments. Working close to the young virtuous performers, Laura Michelin & Filip Korošec, I had the opportunity to write them Bird of Prey. In the pulsing rhythms, we hear the bird hunting its prey and the harmonies enhance the wildlife, to always be on its guard. In the middle of the piece, the listener is getting a high-flying journey to the lamenting song of a Bird of Prey.
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| 10. |
- Berg, Daniel, 1971
(författare)
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Bird of Prey
- 2022
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Ingår i: Köpenhamn, Edition Svitzer, 2022.
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- During the years, I had the opportunity to work together with many excellent flute players and I really think the combination of Flute and Percussion is a perfect match. A lot of great composers have written for the instruments and through them, I got the inspiration to compose for flute and percussion. After composing Dark Shadows, Kinkaku-ji and Second Concerto for Flute & Percussion, all published by Edition Svitzer, I’ve got a question and wish from many flute players to also write something for piccolo and percussion. They are right, there are not so many pieces composed for that combination of instruments. Working close to the young virtuous performers, Laura Michelin & Filip Korošec, I had the opportunity to write them Bird of Prey. In the pulsing rhythms, we hear the bird hunting its prey and the harmonies enhance the wildlife, to always be on its guard. In the middle of the piece, the listener is getting a high-flying journey to the lamenting song of a Bird of Prey.
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