| 1. |
- Alm, Fredrik, 1971-
(författare)
-
Uttryck på schemat och intryck i klassrummet : En studie av lektioner i skolor utan timplan
- 2010
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med föreliggande avhandling är att studera användning och förekomst av lektionsbeteckningar på scheman i skolor utan en nationellt fastställd timplan, samt belysa hur elever upplever de lokala val som görs vad gäller vissa av dessa lektionsbeteckningar. Den teoretiska referensramen har sin grund i didaktikens selektionsfråga och kommunikationsfråga, och Bernsteins båda begrepp klassifikation och inramning. Avhandlingen består av två delstudier. I delstudie I analyseras, såväl kvalitativt som kvantitativt, 326 scheman från 33 skolor som på försök arbetar utan timplan. 163 scheman från skolor med timplan har analyserats i jämförande syfte. I delstudie II genomförs tio gruppintervjuer med totalt 41 elever kring tre typer av icke ämnesrelaterade lektionsbeteckningar (lagtid, verkstad och mentorstid), som är vanligt förekommande på elevers scheman. I avhandlingen visas att en mängd schemabeteckningar (170 stycken) används för att beskriva vad elever och lärare ämnar ägna sig åt. Utöver traditionella ämnen, schemaläggs arbetsmetoder, gruppbaserad tid, skriv- och lästid, social samspelstid, rekreationstid samt lektioner där eleverna involveras i val, planering och utvärdering. Den här typen av alternativa schemabeteckningar används i signifikant större utsträckning i skolorna utan timplan och i de tidigare årskurserna. När skolorna utan timplan använder alternativa beteckningar leder det huvudsakligen till schemapositioner med svagare inramning och svagare klassifikation, samt en förskjutning från innehåll mot metod/form. Eleverna upplever att lektionerna med svagare inramning och klassifikation har ett värdefullt och verklighetsanknutet innehåll, men att de inte är lika viktiga som ämnena. De upplevs ibland vara slöseri med lektionstid. Resultaten diskuteras i ljuset av annan forskning om skolor utan timplan och avhandlingens didaktiska perspektiv.
|
|
| 2. |
- Berg, Svante, 1953-
(författare)
-
On Total Disc Replacement
- 2010
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Low back pain consumes a large part of the community’s resources dedicated to health care and sick leave. Back disorders also negatively affect the individual leading to pain suffering, decreased quality-of-life and disability. Chronic low back pain (CLBP) due to degenerative disc disease (DDD) is today often treated with fusion when conservative treatment has failed and symptoms are severe. This treatment is as successful as arthroplasty is for hip arthritis in restoring the patient’s quality of life and reducing disability. Even so, there are some problems with this treatment, one of these being recurrent CLBP from an adjacent segment (ASD) after primarily successful surgery. This has led to the development of alternative surgical treatments and devices that maintain or restore mobility, in order to reduce the risk for ASD. Of these new devices, the most frequently used are the disc prostheses used in Total Disc Replacement (TDR).This thesis is based on four studies comparing total disc replacement with posterior fusion. The studies are all based on a material of 152 patients with DDD in one or two segments, aged 20-55 years that were randomly treated with either posterior fusion or TDR.The first study concerned clinical outcome and complications. Follow-up was 100% at both one and two years. It revealed that both treatment groups had a clear benefit from treatment and that patients with TDR were better in almost all outcome scores at one-year follow-up. Fusion patients continued to improve during the second year. At two-year follow-up there was a remaining difference in favour of TDR for back pain. 73% in the TDR group and 63% in the fusion group were much better or totally pain-free (n.s.), while twice as many patients in the TDR group were totally pain free (30%) compared to the fusion group (15%).Time of surgery and total time in hospital were shorter in the TDR group.There was no difference in complications and reoperations, except that seventeen of the patients in the fusion group were re-operated for removal of their implants.The second study concerned sex life and sexual function. TDR is performed via an anterior approach, an approach that has been used for a long time for various procedures on the lumbar spine. A frequent complication reported in males when this approach is used is persistent retrograde ejaculation. The TDR group in this material was operated via an extra-peritoneal approach to the retroperitoneal space, and there were no cases of persistent retrograde ejaculation. There was a surprisingly high frequency of men in the fusion group reporting deterioration in ability to have an orgasm postoperatively.Preoperative sex life was severely hampered in the majority of patients in the entire material, but sex life underwent a marked improvement in both treatment groups by the two-year follow-up that correlated with reduction in back pain.The third study was on mobility in the lumbar spinal segments, where X-rays were taken in full extension and flexion prior to surgery and at two-year follow-up. Analysis of the films showed that 78% of the patients in the fusion group reached the surgical goal (non-mobility) and that 89% of the TDR patients maintained mobility.Preoperative disc height was lower than in a normative database in both groups, and remained lower in the fusion group, while it became higher in the TDR group. Mobility in the operated segment increased in the TDR group postoperatively. Mobility at the rest of the lumbar spine increased in both treatment groups. Mobility in adjacent segments was within the norm postoperatively, but slightly larger in the fusion group.In the fourth study the health economics of TDR vs Fusion was analysed. The hospital costs for the procedure were higher for patients in the fusion group compared to the TDR group, and the TDR patients were on sick-leave two months less.In all, these studies showed that the results in the TDR group were as good as in the fusion group. Patients are more likely to be totally pain-free when treated with TDR compared to fusion. Treatment with this new procedure seems justified in selected patients at least in the short-term perspective. Long-term follow-up is underway and results will be published in due course.
|
|
| 3. |
- Roch, Patricia, 1988-
(författare)
-
Monitoring of product variants in biopharmaceutical downstream processing : Mechanistic and data-driven modeling approaches
- 2019
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- During the manufacturing of biopharmaceuticals, a multistep purification strategy is employed to remove process-related impurities and product variants, to achieve high product quality, assuring patients’ safety. To guarantee that biopharmaceuticals are safe and to accomplish quality, strict policies were established by regulatory agencies as well as guiding principles, such as Quality by Design and process analytical technology. To make the manufacturing process economical, relatively high product yield and productivity are also desirable.The removal of product variants often poses a challenge in downstream processing due to their structural similarity to the product resulting in similar behavior. One way of overcoming this issue is to employ additional monitoring tools capable to distinguish between the product and product variants.This thesis demonstrates the development of novel monitoring tools, based on existing monitoring and modeling approaches, to facilitate downstream processing.Existing techniques are evaluated and critically compared toward meeting the requirements on monitoring quality attributes in downstream processing.A mechanistic model-based monitoring tool was established for a reversed phase chromatography polishing step of insulin to predict the elution profile of insulin and two insulin variants. By relying on model-based monitoring a significant increase in product yield was achieved.Further, multi-wavelength fluorescence spectroscopy coupled with the multi-way algorithm parallel factor analysis was utilized to monitor product variants of biopharmaceuticals in downstream processing. This monitoring tool capitalizes on a shift in fluorescence emission between the product and its variant. Developed for monitoring aggregates during antibody purification, the transferability of the approach to other relevant biopharmaceuticals, such as factor VIII and erythropoietin, has been confirmed.The monitoring tools developed in this thesis, extend existing monitoring tools for downstream processing of biopharmaceuticals. When implementing these monitoring tools into the different phases of biopharmaceuticals’ lifespan, their potential could range from optimizing downstream processes during purification strategy development to supporting manufacturing by facilitating process decisions.
|
|
| 4. |
- Billmayer, Jakob, 1983-
(författare)
-
Ska dörren vara öppen? : Disciplin i klassrummet i Sverige och Tyskland
- 2015
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this study is to investigate discipline in German and Swedish classrooms and describe its cultural contexts. In countries with compulsory education, it must be assumed that not all students voluntarily attend classes. The mandatory presence of students combined with the ban on corporal punishment in schools means that classroom interaction has to be organized according to certain manners and rules (Luhmann, 2002a:108a). These rules are understood here as discipline meaning the organization and control of individuals and their actions over space and time (Foucault, 1987/1975). This study assumes similarities in the fundamental disciplinary mechanisms, although different contexts (here Germany and Sweden) will create different concrete manifestations of the phenomenon. Since the observation of cultural contexts is not as self-evident and direct as the observation of classroom interactions of teachers and students, the theoretical considerations here include a detailed discussion of methodology for observing culture. Starting with Alfred Schütz’ concept of ideal types and Niklas Luhmann’s theory on massmedia, it is argued that culture can be observed through the products of mass media. The empirical data for this study consists of field studies in the form of observations in German and Swedish classrooms as well as the examination of Germanand Swedish films and television series about teachers and students. The classroom observations were used to create ideal typical descriptions of different implementations of disciplinary procedure. Based on the analysis of teacher figures in various German and Swedish films and television series, several “good” and “bad” teacher types were initially identified. Combining the two results allowed conclusions tobe made about correlations between disciplinary order and whether a teacher is considered “good” or “bad”. This review of the various types of order is the basis for the description of cultural contexts. The results of classroom observations and film studies and their discussion in relation to prior Swedish research, gives the picture of a cultural context in which various forms of classroom order are avail-able, in which they are critically discussed and also can exist in parallel to each other. On the other hand, the German context seems to allow only one form of classroom order, both in actual school operations as well as in the mass media representation and scientific reflection.
|
|
| 5. |
- Dahlgren, Inger, 1942-
(författare)
-
Analys av en utvärderingsmodell för förebyggande arbete inom socialpedagogiskt hälsoarbete
- 2008
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The main purpose of this thesis is to find, test and develop a method/model for evaluating socio-educational work in mental health. The intention is not to do a complete evaluation but rather to illustrate how a model can be applied.The starting point is a model of self-assessment that shares many similarities with both programme-evaluation and evaluation with the use of stakeholders. The arguments used for evaluation in this study are based mainly on the aims to ‘promote and improve’ and ‘develop and critically analyse’. The arguments used to support a user-orientation are the service-adaptation argument and the bottom-up perspective.A self-assessment model i.e. an institutional and professional model was utilized for this evaluation because the service studied was a collaborative, preventive effort between Social Services and Primary Care focused on families with children. The model for self-assessment is combined with ‘SWOT-thinking’ which will assist planning, implementation and evaluation of a complex service.This model takes both the target group/target groups, the staff and the organisation into consideration. The frame factors, the process and the achievements are analysed for each of the included components. This model facilitates studying the relationships between the various parts of the model and further allows for a bottom-up and top-down perspective and for shifting between the various perspectives.This study is important because it demonstrates that several aspects of complex services can be studied with the aid of a self-assessment model. The model can be applied to planning, development, quality assurance and evaluation. By studying relationships within the model it is possible to proceed from any one segment in the model and follow how it influences every other segment. Thus it is possible to some extent predict later complications or highlight areas requiring further attention.
|
|
| 6. |
- Dahlkwist, Matts, 1950-
(författare)
-
En landsbygdens skolreform? : Den geografiska dimensionen i bygget av en enhetsskola
- 2022
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- A fundamental organizational idea in the construction of a nine-year coherent unit school in Sweden 1928–1972, with geographical equality as a subgoal, consisted of a national uniformity in terms and content, with centralization as an overall tool (strategy area 1). At the same time, this school would be designed after local needs and conditions (strategy area 2). The main purpose and the investigation in the dissertation consist of the relationship between these two strategy areas in a smaller rural municipality. A categorization has been made in its various aspects of national and local level: first the uniformity of the school time, second in shape (school-form and school size), as well as the third, compensatory measures to compensate for centralization's disadvantages in the countryside. The thesis takes its starting point in a historical micropolitical longitudinal study, in order to capture how a local school organization acted in relation to national intentions and decisions, through studies of the interaction and the conflict pattern between actors of significance, in accordance with Lipsky's theory of Street Level Bureaucrats (here: the country road bureaucrats). The main results of the empirical study shows that even from a rural perspective, the school's centralization process was considered necessary in the work to achieve geographical equalization. When a conflict between the both strategy areas occur, was national uniformity prioritized in front of manifestation of local space. The cross-pressure position of the country road bureaucrats were characterized by the fact that they often ended up in a cross-pressure position between parents on one side and school inspector on the other hand. In conflict situations, the country road bureaucrats used to came to act in coalition with any other actor.
|
|
| 7. |
- Berg, Anna, 1975-
(författare)
-
Effects of nitric oxide on gastric acid secretion in human gastric mucosa : functional and morphological studies
- 2005
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Hydrochloric acid (HCI) is secreted in high amounts by parietal cells in the human gastric mucosa and the resulting low pH constitutes an important factor for creating a suitable environment for the digestion. The normal gastric mucosa is equipped with an arsenal of protective mechanisms against the extreme chemical environment which the gastric acid creates. There are situations when the barrier function of the gastric mucosa is disrupted and gastric acid becomes potentially deleterious. Understanding the regulatory mechanisms by which the secretion of gastric acid is controlled under physiological conditions may improve future treatment in peptic ulcers, gastritis and other gastric inflammatory disorders.Nitric oxide (NO) has previously been found to regulate gastric acid secretion in animals. Immunohistochemical investigation of normal human gastric mucosa revealed that hitherto unknown endocrine cells in the oxyntic mucosa express nitric oxide synthase (NOS). These cells were found located in close contact with parietal cells, which suggests a paracrine effect of NO on parietal cell function.Functional studies of the effects of exogenous and endogenous NO on stimulated gastric acid secretion were performed on isolated human gastric glands. Indirect determination of gastric acid secretion by using the 14C-labeled aminopyrine (AP) technique was used. Stimulation was induced by administration of histamine or db-cAMP. Secretagogue-induced AP-accumulation in gastric glands treated with NO-donor was significantly decreased compared with untreated glands. This indicates that exogenously administered NO inhibits stimulated gastric acid secretion in humans. Inhibition of endogenous NO-production by the use of NOS-inhibitors caused an increase in AP-accumulation, which suggests that NO released from cells within the glandular epithelium exerts a physiological effect in acting as an inhibitor of stimulated gastric acid secretory activity in humans.Further functional and morphological investigations showed that exogenously administered cGMP induced a concentration-dependent inhibition of AP-accumulation in isolated human gastric glands similar to that induced by NO-donors. When soluble guanylate cyclase (sGC), a common target enzyme for NO, was blocked NO failed to induce inhibition. Biochemical analysis of the cGMP concentrations in isolated gastric glands after treatment with NO-donor revealed that inhibition of AP-accumulation due to NO is accompanied by an increase in glandular cGMP content. This increase was localized by immunohistochemistry to the parietal cells. These results indicates that NO inhibits secretagogue-induced gastric acid secretion in isolated human gastric glands via activation of sGC, which results in an increased concentration of cGMP in the parietal cells.In order to determine the cGMP-dependent mechanisms leading to diminished output of gastric acid, parietal cells were investigated with emphasis on the cytological transformations associated with stimulation of acid secretion. Isolated human gastric glands were treated with NO-donor prior to administration of histamine. The cytoskeletal rearrangement as well as the translocation and incorporation of H+/K+-ATPase into the apical membrane was studied using con focal and electron microscopy techniques. Results showed that histamine-induced F-actin rearrangement as well as the translocation of H+/K+-ATPase rich tubulovesicles to the canalicular membrane, and their fusion with the same, was unaffected by NO. The secretory canaliculi, which swell to great size as a result of histamine-treatment, were however small and unexpanded in response to treatment with NO-donor. The unexpanded canaliculi reflected the NO-induced inhibition of secretion of HCI observed in the functional studies.In conclusion, these results show that NO may be a physiological regulator of stimulated gastric acid secretion in humans and that this inhibition is a cGMP-dependent mechanisms which diminishes output of HCI from parietal cells without affecting stimuli-induced cytological transformations.
|
|
| 8. |
- Berg, Gunnar
(författare)
-
Företagskulturers makt : överbrygga språkliga klyftor
- 2008
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- How do we work in projects that are expected to bridge cultural, social and historical boundaries? Is it possible to apply stated instructions across these boundaries so that, for example, the task of producing a requirement specification is interpreted in the same way by all the parties involved? In this thesis, the author takes a stand against his personal experience from such a trans-cultural project – a project in which he failed. A factor that made a strong contribution to this failure was the inability of the companies involved to manage the underlying complex of problems, problems associated with the philosophy of language. They possessed neither the knowledge nor the instruments to bridge the chasms of language. Essential reflection and analysis was replaced by the power language of the enterprise; individuals were singled out and held responsible, and the failure was relegated by definition to the level of personal issues. Experience does not automatically become knowledge; this is a process that requires reflection. The author suggests a number of ways of tackling communications problems among people who not only do not understand one another, but do not understand that they do not understand. The latter may mean that two people think that something is unambiguous, yet their interpretations diverge. This is when problems occur. Nobody has made a mistake – both parties have acted properly, they have even (perhaps) talked the matter through and reached agreement, yet the result still does not coincide with what they anticipated. A central concept is dialogue. Through its organised form, dialogue can make openings in problems that cut through cultural, social and historical boundaries. It is an approach that may be illustrated through authors and philosophers such as Witold Gombrowicz, Ludwik Fleck, Oscar Wilde, Joseph Conrad and Galileo Galilei. This study has its basis and its origins in the research area of Skills and Technology at the Royal Institute of Technology, Stockholm (KTH).
|
|
| 9. |
- Oxenswärdh, Anette, 1956-
(författare)
-
Ansvarsförhållanden vid skolutveckling
- 2011
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Relations of Responsibility in School DevelopmentABSTRACTThe starting point of this study is the changed governance of schools in Swe- den. Decentralization has not only increased the freedom of schools but also responsibility at the different levels of the school system. This in turn has given greater scope for interpreting the assignment. In recent years, however, a cer- tain return to regulation has been evident. Theoretically the concept of respon- sibility is elucidated as a term in philosophy, organisation theory, and psychology-education. Responsibility in school can be described as a relation- ship between the commissioner’s exaction of responsibility and the contrac- tor’s assumption of responsibility. This can cause uncertainty in matters of responsibility. Active school measures may be viewed as a way to clarify re- sponsibility issues. For this study, two models of school development have been selected in order to study how they affect the school actors’ understan- ding of assignment and responsibility. Two case studies examine a number of conceptual dimensions that illustrate different aspects of the assumption of re- sponsibility.The results show that these two development models and the active measures to which they give rise shape in various ways the actors’ under- standing of assignment and responsibility. These can be considered to place the emphasis on different parts of the control system. The Scope for Action Model emphasizes the role of the local school with the aid of a bottom-up strategy as regards the school’s assumption of responsibility. The Effective Schools Model emphasizes the political level in a more top-down strategy. This means, in practice, that the Scope for Action Model for school devel- opment tries with the aid of culture analysis to clarify responsibility relations by making the actors in the organization aware of their accountability and the potential involved in their assignment. The Effective Schools Model, in contrast, clarifies relations of responsibility by pointing out deficiencies in the school organization in relation to the assignment and the responsibility it entails. The main results show that the school development models contrib- uted to increased cooperation between professionals, partly by exposing the organization and its boundaries, management, and different occupational roles. The cooperation exposes the obstacles but also the opportunities for change and development in the school’s own organization.Another important finding is that, in the work of school development, there was heavy focus on making activities more pupil-oriented by highlighting the task of both upbringing and teaching among all staff. Shortage of time, deficient organizational structures, and increased administration were per- ceived as obstructing the fulfilment of the assignment.A further finding is that the school development models led to the exposure and creation of responsibility structures in the schools. Structures revealed inc- luded the organizational structure, management structures, communication and cooperation structures such as the teacher team and different kinds of deve- lopment groups. Responsibility structures were created through firmer structu- ring of cooperation between teachers and parents and through the formation of groups for cooperation and development.All these active measures furthered the individual and collective learning processes through which the professionals’ understanding of assignment and responsibility is (re)shaped. This understanding in turn constitutes an essential part of the professionals’ competence development and professional develop- ment. Some conclusions that can be drawn from the study are that knowledge of the school’s responsibility reduces the discrepancy and helps professionals to improve their competence and develop the school. The professionals’ auto- nomy is essential for increased commitment, motivation, and understanding.Proceeding from the professionals’ own needs when implementing de- velopment measures further increases their motivation and serves as a motor driving the work of development.The learning process should be staged and designed as different arenas for more effectively satisfying the different needs of competence in the pro- fessionals. School development as learning should be continuous, with the aid of organization, support, leadership, and encouragement. School devel- opment should be the responsibility of all levels.
|
|
| 10. |
- Pejlare, Johanna, 1976
(författare)
-
On Axioms and Images in the History of Mathematics
- 2007
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This dissertation deals with aspects of axiomatization, intuition and visualization in the history of mathematics. Particular focus is put on the end of the 19th century, before David Hilbert's (1862–1943) work on the axiomatization of Euclidean geometry. The thesis consists of three papers. In the first paper the Swedish mathematician Torsten Brodén (1857–1931) and his work on the foundations of Euclidean geometry from 1890 and 1912, is studied. A thorough analysis of his foundational work is made as well as an investigation into his general view on science and mathematics. Furthermore, his thoughts on geometry and its nature and what consequences his view has for how he proceeds in developing the axiomatic system, is studied. In the second paper different aspects of visualizations in mathematics are investigated. In particular, it is argued that the meaning of a visualization is not revealed by the visualization and that a visualization can be problematic to a person if this person, due to a limited knowledge or limited experience, has a simplified view of what the picture represents. A historical study considers the discussion on the role of intuition in mathematics which followed in the wake of Karl Weierstrass' (1815–1897) construction of a nowhere differentiable function in 1872. In the third paper certain aspects of the thinking of the two scientists Felix Klein (1849–1925) and Heinrich Hertz (1857–1894) are studied. It is investigated how Klein and Hertz related to the idea of naïve images and visual thinking shortly before the development of modern axiomatics. Klein in several of his writings emphasized his belief that intuition plays an important part in mathematics. Hertz argued that we form images in our mind when we experience the world, but these images may contain elements that do not exist in nature.
|
|
