| 1. |
- Berg, Lotta, et al.
(författare)
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Similar but Different : Thermodynamic and Structural Characterization of a Pair of Enantiomers Binding to Acetylcholinesterase
- 2012
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Ingår i: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 51:51, s. 12716-12720
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Tidskriftsartikel (refereegranskat)abstract
- Take a closer look: Unexpectedly, a pair of enantiomeric ligands proved to have similar binding affinities for acetylcholinesterase. Further studies indicated that the enantiomers exhibit different thermodynamic profiles. Analyses of the noncovalent interactions in the protein-ligand complexes revealed that these differences are partly due to nonclassical hydrogen bonds between the ligands and aromatic side chains of the protein.
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| 2. |
- Berg, Sandra, 1984, et al.
(författare)
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Knowledge transfer within and across organizational boundaries: A case study in the construction industry
- 2012
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Ingår i: ARCOM 28th Annual Conference, Edinburgh, 3-5 September 2012. ; 1
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Konferensbidrag (refereegranskat)abstract
- Knowledge transfer is essential for an organization to be competitive and successful. However, as projects are temporary, knowledge is often bound to the individuals in projects rather than to the core organizations. The main research question for this article is: How can collaboration be used in order to transfer knowledge from one project to another within an organization or with other organizations within a project? To do this, a theoretical framework of recent literature concerning knowledge management and transfer is used, as well as a case study about an urban development organization working with a rather unique collaboration structure in order to maximize the knowledge transfer from and between different actors. Our method of research has been interviews with a divisional manager and two project managers at an urban development organization. Results from our case study indicate that in the planning phase, knowledge transfer includes collecting feedback and information as well as using a central knowledge platform. During the production phase, face-to-face communication is the most important form of knowledge transfer. After each project, evaluation is essential to collect the experience of collaboration and identify planning errors. Our findings also show that most knowledge transfer occurs at an informal level. The study concludes that several factors affect knowledge transfer in a construction organization. The most essential are the media in which knowledge is transferred and the way information is stored. Taking all factors into consideration, an organization with a decentralized structure and an open and broad-minded culture enables successful knowledge transfer.
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| 4. |
- Collin, Sven-Olof Yrjö, et al.
(författare)
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The auditor as consigliere in family firm
- 2017
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Ingår i: Journal of Family Business Management. - : Emerald Group Publishing Limited. - 2043-6238 .- 2043-6246. ; 7:1, s. 2-20
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Tidskriftsartikel (refereegranskat)abstract
- PurposeThe purpose of this paper is to develop and test a concept of auditor as consigliere in family firms, that captures additional functions to monitoring, those of advice, mediating, and conveying.Design/methodology/approachThe concept is tested through a survey conducted on 309 Swedish auditors.FindingsThe data indicate that the consigliere role is generally not emphasized, indicating that auditors primarily perform the monitoring role of the audit. However, the authors do find indications of the auditor performing the consigliere role, through performing the advisory and mediating functions and, to a smaller degree, the conveying function.Research limitations/implicationsThe survey is limited in response rate and in separating governance situations from consigliere functions.Practical implicationsWith reservation for professional independence, the auditor as consigliere could be part of the governance of the family firm, but should be trained for this activity.Social implicationsRegulators should pay attention to the consigliere role when, for example, stipulating compulsory rotation of auditors.Originality/valueThe paper shows that the auditor is more than a monitor in family firms. The consigliere role, even if not at all dominating, has to be considered, at least in family firms.
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| 5. |
- Dillner, Pernilla, et al.
(författare)
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Incidence and characteristics of adverse events in paediatric inpatient care : a systematic review and meta-analysis
- 2023
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Ingår i: BMJ Quality and Safety. - : BMJ. - 2044-5415 .- 2044-5423. ; :3, s. 133-149
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Adverse events (AEs) cause suffering for hospitalised children, a fragile patient group where the delivery of adequate timely care is of great importance.OBJECTIVE: To report the incidence and characteristics of AEs, in paediatric inpatient care, as detected with the Global Trigger Tool (GTT), the Trigger Tool (TT) or the Harvard Medical Practice Study (HMPS) method.METHOD: MEDLINE, Embase, Web of Science and Google Scholar were searched from inception to June 2021, without language restrictions. Studies using manual record review were included if paediatric data were reported separately. We excluded studies reporting: AEs for a specific disease/diagnosis/treatment/procedure, or deceased patients; study protocols with no AE outcomes; conference abstracts, editorials and systematic reviews; clinical incident reports as the primary data source; and studies focusing on specific AEs only. Methodological risk of bias was assessed using a tool based on the Quality Assessment Tool for Diagnostic Accuracy Studies 2. Primary outcome was the percentage of admissions with ≥1 AEs. All statistical analyses were stratified by record review methodology (GTT/TT or HMPS) and by type of population. Meta-analyses, applying random-effects models, were carried out. The variability of the pooled estimates was characterised by 95% prediction intervals (PIs).RESULTS: We included 32 studies from 44 publications, conducted in 15 countries totalling 33 873 paediatric admissions. The total number of AEs identified was 8577. The most common types of AEs were nosocomial infections (range, 6.8%-59.6%) for the general care population and pulmonary-related (10.5%-36.7%) for intensive care. The reported incidence rates were highly heterogeneous. The PIs for the primary outcome were 3.8%-53.8% and 6.9%-91.6% for GTT/TT studies (general and intensive care population). The equivalent PI was 0.3%-33.7% for HMPS studies (general care). The PIs for preventable AEs were 7.4%-96.2% and 4.5%-98.9% for GTT/TT studies (general and intensive care population) and 10.4%-91.8% for HMPS studies (general care). The quality assessment indicated several methodological concerns regarding the included studies.CONCLUSION: The reported incidence of AEs is highly variable in paediatric inpatient care research, and it is not possible to estimate a reliable single rate. Poor reporting standards and methodological differences hinder the comparison of study results.
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| 6. |
- Garmy, Pernilla, et al.
(författare)
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A qualitative study exploring adolescents' experiences with a school-based mental health program
- 2015
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Ingår i: BMC Public Health. - : Springer Science and Business Media LLC. - 1471-2458. ; 15
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Supporting positive mental health development in adolescents is a major public health concern worldwide. Although several school-based programs aimed at preventing depression have been launched, it is crucial to evaluate these programs and to obtain feedback from participating adolescents. This study aimed to explore adolescents' experiences with a -based cognitive-behavioral depression prevention program.METHODS: Eighty-nine adolescents aged 13-15 years were divided into 12 focus groups. The focus group interviews were analyzed using qualitative content analysis.RESULTS: Three categories and eight subcategories were found to be related to the experience of the school-based program. The first category, intrapersonal strategies, consisted of the subcategories of directed thinking, improved self-confidence, stress management, and positive activities. The second category, interpersonal awareness, consisted of the subcategories of trusting the group and considering others. The third category, structural constraints, consisted of the subcategories of negative framing and emphasis on performance.CONCLUSIONS: The school-based mental health program was perceived as beneficial and meaningful on both individual and group levels, but students expressed a desire for a more health-promoting approach.
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| 9. |
- Garmy, Pernilla, et al.
(författare)
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Att förebygga depressiva symtom hos ungdomar : en pilotstudie
- 2014
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Bakgrund: Att främja välmående och psykisk hälsa hos barn och ungdomar är en viktig uppgift för samhället. Psykisk ohälsa, t ex depression och ångest, innebär en försämrad livskvalitet som kan försvåra barnets kognitiva, sociala och känslomässiga funktioner. Att främja en positiv utveckling och förebygga barns och ungas psykiska ohälsa innebär både ett minskat individuellt lidande och minskade samhällskostnader. Förutsättningen är dock att förebyggande åtgärder är effektiva ur såväl hälsomässiga som ekonomiska perspektiv. Syfte: Att utvärdera det skolbaserade programmet Disa som syftar till att förebygga depressiva symptom hos ungdomar. Metod: Studien, som har en kvasiexperimentell design, inkluderade pre-test, post-test och ett-års-uppföljning samt en illustrativ beräkning av interventionens implementeringskostnader. I studien deltog 62 elever i årskurs 8, samt 7 Disa-ledare. Resultat: En majoritet av eleverna och samtliga ledare var nöjda med interventionen. Eleverna, både flickorna och pojkarna, skattade sina depressiva symtom signifikant lägre efter kursen, och för flickorna bestod denna effekt vid ett-års-uppföljningen. Implementeringskostnaderna för de första två åren var cirka 2000 kr per elev. Slutsats: Positiva resultat av det skolbaserade programmet Disa påvisades, särskilt för flickor. Flera elever tyckte att de fått ett nytt sätt att tänka, och att stämningen förbättrades i klassen. Svar på frågan “Vad tyckte du om Disa-kursen?” ”Mycket bra! Bättre stämning i klassen efter det! Mysigt!” – Flicka ”Helt okej, märkte ingen skillnad efter. Mådde i och för sig inte dåligt innan heller.” – Flicka ”Den har varit bra, man har fått ett nytt sätt att tänka på.” – Flicka ”Intressant och gav perspektiv” – Pojke ”Tråkigt” - Pojke ”Bra att få tips hur man kan undvika negativa tankar snabbt!” – Pojke
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