| 1. |
- Steneberg, Pär, et al.
(författare)
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PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients
- 2018
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Ingår i: JCI INSIGHT. - : American Society for Clinical Investigation. - 2379-3708. ; 3:12
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Tidskriftsartikel (refereegranskat)abstract
- AMPK activated protein kinase (AMPK), a master regulator of energy homeostasis, is activated in response to an energy shortage imposed by physical activity and caloric restriction. We here report on the identification of PAN-AMPK activator O304, which - in diet-induced obese mice - increased glucose uptake in skeletal muscle, reduced beta cell stress, and promoted beta cell rest. Accordingly, O304 reduced fasting plasma glucose levels and homeostasis model assessment of insulin resistance (HOMA-IR) in a proof-of-concept phase IIa clinical trial in type 2 diabetes (T2D) patients on Metformin. T2D is associated with devastating micro-and macrovascular complications, and O304 improved peripheral microvascular perfusion and reduced blood pressure both in animals and T2D patients. Moreover, like exercise, O304 activated AMPK in the heart, increased cardiac glucose uptake, reduced cardiac glycogen levels, and improved left ventricular stroke volume in mice, but it did not increase heart weight in mice or rats. Thus, O304 exhibits a great potential as a novel drug to treat T2D and associated cardiovascular complications.
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| 2. |
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| 3. |
- Bankel, Johan, et al.
(författare)
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The CDIO syllabus: a comparative study of expected student proficiency
- 2003
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Ingår i: European Journal of Engineering Education. - : Taylor & Francis. - 0304-3797 .- 1469-5898. ; 28:3, s. 297-315
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Tidskriftsartikel (refereegranskat)abstract
- Engineering students must graduate with command of a vast body of technical knowledge. They must possess personal, interpersonal and system-building skills to function in teams, and be prepared to produce products and systems. Their education must have been structured under a curriculum blending ability to combine technical expertise with ethical, innovative, philosophical and humanistic acumen. This paper describes a unique international collaboration among four universities to reform engineering education. The collaborators agreed to a statement of goals, which includes descriptions of knowledge, skills and attitudes vital to an effective education, and codifies proficiency levels expected of graduates. We developed and utilized unique stakeholder surveys both to validate our prototype and to determine desired proficiency levels. This collaboration resulted in The CDIO Syllabus, A Statement of Goals for Undergraduate Engineering Education. The syllabus is both a template and a process that can be used to customize the syllabus to others' programmes. It can define new educational initiatives/and be employed as the basis for rigorous assessment. This paper details how, with the input of industry, academia and others, we employed an engineering problem-solving paradigm to effect our redesign. It outlines the syllabus and the unique process employed to create it.
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| 4. |
- Bégat, Ingrid, 1942-, et al.
(författare)
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Australian nurse supervisors' styles and their perceptions of ethical dilemmas within health care
- 2003
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Ingår i: Journal of Nursing Management. - : Hindawi Limited. - 0966-0429 .- 1365-2834. ; 11:1, s. 6-14
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To examine clinical nurse supervisors' styles, in terms of models, organization, focus on supervision and theories used in supervision, as well as their perceptions of ethical dilemmas within health care. BACKGROUND: The importance of clinical supervision in clinical practice has been reported. However, literature dealing with its implementation is rare. METHODS: This study is a descriptive-correlational study. Data were collected by means of a questionnaire from two groups of nurse supervisors randomly selected from a university (n = 55) and a hospital (n = 31). Data were analysed using descriptive and inferential statistics. RESULTS: The models most frequently used were 'case-oriented' and 'decision-making oriented'. The nurse supervision was reported as being organized on a one-to-one basis. The focus of supervision was on 'patient problems' and 'cooperation in team'. The theory most commonly used was the theory of reflection. The supervisors' perceptions of moral dilemmas were related to 'decision making' and actions impacting on quality of care resulting from their supervisor styles. CONCLUSION: By correlating the supervisors' styles and their perceptions of ethical dilemmas, we conclude that it is important to contribute to further research on supervisors' styles in order to ensure successful supervision.
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| 5. |
- Bégat, Ingrid, 1942-, et al.
(författare)
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Implementation of clinical supervision in amedical department: nurses' views of the effects
- 1997
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Ingår i: Journal of Clinical Nursing. - United Kingdom : Wiley Blackwell Publishing Ltd.. - 0962-1067. ; 6:5, s. 389-394
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this pilot study was to investigate nurses' views of the effects of clinical supervision in terms of its influence over their working situation, as well as their satisfaction with their working milieu. The nurses who took part in an education programme and a clinical supervision programme worked on two wards in a medical clinic. Nurses answered a questionnaire measuring the psychosocial environment. Data were analysed by means of descriptive statistics. Results showed that the nurses felt more confirmed in their work and more satisfied with the information given after 9 months of clinical supervision. Results point to the need for further investigations concerning clinical supervision as a method of achieving job satisfaction among nurses.
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| 6. |
- Berggren, Ingela, 1948-, et al.
(författare)
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Australian clinical nurse supervisors' ethical decision-making style
- 2002
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Ingår i: Nursing and Health Sciences. - : Wiley. - 1441-0745 .- 1442-2018. ; 4:1-2, s. 15-23
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Tidskriftsartikel (refereegranskat)abstract
- This paper explores clinical nurse supervisors' ethical styles with regard to supervision in healthcare. Eighty-six registered nurses, all with experience of supervising clinical nurses and students in nursing, completed a specifically designed questionnaire. A qualitative interpretative content analysis identified three core themes: (i) 'Is it safe?'; (ii) 'Is it right?'; and (iii) 'Is it kind?', describing the clinical nurse supervisors' ethical styles. The first core theme 'Is it safe?' covered the supervisors' rules, codes and values that guide their supervisory actions, as well as two sub-themes: (i) empowerment and (ii) integrity. The second core theme 'Is it right?' described the supervisors' responsibility and advocacy as well as the ethical dilemmas experienced in the supervisory process. The third core theme 'Is it kind?' included the supervisors' relationships with patients, professionals and supervisees. The results demonstrate the value of offering a support system, such as clinical supervision, which helps nurses to explore their professional identity for the benefit of the patients.
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| 7. |
- Berggren, Ingela, 1948-, et al.
(författare)
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Core ethical issues of clinical nursing supervision
- 2005
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Ingår i: Nursing and Health Sciences. - : Wiley. - 1441-0745 .- 1442-2018. ; 7:1, s. 21-8
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Tidskriftsartikel (refereegranskat)abstract
- Clinical nursing supervision enables supervisees to reflect on ethically difficult caring situations, thereby strengthening their professional identity, integrating nursing theory and practice, and leading to the development of ethical competence. The aim of this study was to develop an understanding of the core ethical issues of clinical nursing supervision, using previous research as well as philosophical analysis of the theories of three moral philosophers: Harald Ofstad, Richard Hare and Carol Gilligan. The ultimate aim of this study was to develop a general model for ethical decision-making and to establish its relevance for clinical nursing supervision. The findings highlight four important values for the development of a basis for ethical decision-making. These values are caring, dignity, responsibility and virtue.
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| 8. |
- Berggren, Ingela, 1948-, et al.
(författare)
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Decision making within a community provider organization
- 2010
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Ingår i: British Journal of Community Nursing. - 1462-4753 .- 2052-2215. ; 15:12, s. 611-617
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To explore community nurses' experiences of decision making within the community provider organization. Background: Recent changes in health care with an increasing number of patients being cared for outside of institutions can put considerable pressure on the nurse with respect to decision making. Methods: In-depth interviews were performed with 6 registered nurses in two communities. The interviews were analysed by means of phenomenological hermeneutics. Results: The community nurses' experiences of decision making were interpreted as spiders or octopuses, consultants and troubleshooters. The subthemes were; networking and structuring, responsibility, availability and knowledge, assessment power, information selection, avoiding rules and bypassing managers. In accordance with hermeneutical phenomenology, the findings were discussed and explained with reference to Ofstad's philosophy of freedom to make decisions. Conclusion: In their decision making, community nurses are committed to finding administrative solutions that satisfy patient needs.
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| 9. |
- Berggren, Ingela
(författare)
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Etisk undran i omvårdnadshandledning
- 2014
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Ingår i: Hermeneutik i vårdpraxis. - Malmö : Gleerups Utbildning AB. - 9789140681737 ; , s. 187-196
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Berggren, Ingela, 1948-
(författare)
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Etiska kärnbegrepp i omvårdnadshandledning
- 2009. - 1.
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Ingår i: Omvårdnadshandledning. - Lund : Studentlitteratur. - 9789144053233 ; , s. 193-209
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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