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- Fredriksson, Maria, 1966-
(författare)
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Esculapius’ De stomacho : Edited with an Introduction, Translation, and Commentary
- 2002
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This dissertation contains an edition, followed by an English translation, of chapter 21, De stomacho, from the so-called Esculapius or Liber Esculapii. The dissertation offers a diplomatic-interpretative edition of the Latin text of the manuscript Uppsala C 664, a miscellaneous medical manuscript containing i.a. the chapter De stomacho. Liber Esculapii, a work on chronic illnesses, was compiled some time in late antiquity from Methodist and Dogmatic sources. Part of Esculapius is almost certainly a translation of a Greek source, or based on a previous translation. In the extant manuscripts it is usually preceded by a work on acute illnesses, the author of which is referred to as Aurelius. Esculapius’ text is partly based on the Medicinales responsiones of Caelius Aurelianus and can be of use in reconstructing lost parts of the text of Caelius. It also exhibits strong similarities with substantial parts of the Greek treatise De re medica of Paulus Nicaeus. Esculapius is preserved in a large number of early mediaeval manuscripts and was an influential source of mediaeval compilations, such as Gariopontus and Practica Petroncelli. A manuscript of Esculapius was probably also used for the medical glosses of Liber glossarum.The present work consists of an introduction describing medical schools in antiquity and discussing the date, sources and influence of Esculapius. This is followed by a description of the language of Esculapius, the extant manuscripts, and the textual tradition, text, an English translation, a commentary, and studies of some words of special interest.
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- Lindskog, Bengt I., et al.
(författare)
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Medicinsk terminologi
- 2004
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Bok (övrigt vetenskapligt/konstnärligt)
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- Persson, Elisabet, 1959, et al.
(författare)
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Antimicrobial susceptibility of invasive group B streptococcal isolates from south-west Sweden 1988-2001.
- 2008
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Ingår i: Scandinavian journal of infectious diseases. - : Informa UK Limited. - 0036-5548 .- 1651-1980. ; 40:4, s. 308-13
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Tidskriftsartikel (refereegranskat)abstract
- The antibiotic susceptibility of 297 invasive isolates of group B streptococci (GBS) to a panel of 12 antibiotics was analysed using the E-test. The isolates (from 123 neonates and 174 adults) were collected from south-west Sweden during the 2 periods 1988-1997 and 1998-2001. The breakpoints of the Clinical and Laboratory Standards Institute were used. All isolates were sensitive to cefotaxime, meropenem, linezolid, vancomycin, moxifloxacin and quinupristin-dalfopristin. Two strains displayed a slightly decreased susceptibility to penicillin G (MIC 0.25 microg/ml) also when tested by the broth dilution method. Two per cent were resistant to erythromycin and 1% to clindamycin. Strains with intermediate sensitivity to erythromycin and clindamycin increased over the 2 study periods. 68% were resistant to doxycycline, and the resistance rate for doxycycline increased over the 2 study periods. No strain was resistant to trimethoprim-sulfamethoxazole. Serotype V dominated among strains with intermediate susceptibility to erythromycin and clindamycin. There were no other relationships between serotypes and decreased sensitivity to any agent. There were no significant differences in susceptibility to any agent tested between strains isolated from neonates and adults. In conclusion, penicillins remain the drug of choice in the region but with the increasing rates of intermediate susceptibility to both erythromycin and clindamycin, antibiotic sensitivity analysis should be performed on the GBS isolates from penicillin-allergic patients.
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- Persson, Elisabet, 1959, et al.
(författare)
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Characterisation of invasive group B streptococci based on investigation of surface proteins and genes encoding surface proteins.
- 2008
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Ingår i: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. - : Elsevier BV. - 1198-743X. ; 14:1, s. 66-73
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Tidskriftsartikel (refereegranskat)abstract
- The joint distributions of the six genes bca, bac, epsilon/alp1, alp2, alp3 and rib (encoding alpha-C-protein, beta-C-protein, epsilon/Alp1, Alp2, Alp3, and Rib, respectively) and the proteins alpha-C-protein, beta-C-protein and Rib were investigated in invasive isolates of group B streptococcus (GBS). In total, 297 invasive isolates (123 from neonates, 174 from adults) from south-west Sweden were collected during a 13-year period. Genes were detected using multiplex and specific PCRs, and expression of the surface proteins was demonstrated using monoclonal antibodies. The genes studied were found alone or in combinations in 294 (99%) of the invasive isolates. The most common genes were rib (n = 127 isolates, 43%), alp3 (n = 78, 26%) and epsilon/alp1 (n = 42, 14%). The bac gene was never found alone, but was found in combination with one other gene in 36 isolates. The surface proteins studied were detected alone or in combinations in 152 (51%) isolates, with the most common being Rib (n = 80, 27%), alpha-C-protein (n = 68, 23%) and beta-C-protein (n = 24, 8%). Several genes were associated significantly with particular serotypes (e.g., epsilon/alp1 with serotype Ia; bca and bac with serotypes Ib and II; rib with serotype III; alp3 with serotype V). Overall, it was concluded that demonstration of different genes and surface proteins of GBS strains can be useful in epidemiological studies and in formulation of vaccines, but disappointingly, no single gene or surface protein included in the study was sufficiently common for it to be considered as the basis for a successful GBS vaccine.
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