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- Beral, V, et al.
(författare)
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Alcohol, tobacco and breast cancer - collaborative reanalysis of individual data from 53 epidemiological studies, including 58515 women with breast cancer and 95067 women without the disease
- 2002
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Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 87, s. 1234-45
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Tidskriftsartikel (refereegranskat)abstract
- Alcohol and tobacco consumption are closely correlated and published results on their association with breast cancer have not always allowed adequately for confounding between these exposures. Over 80% of the relevant information worldwide on alcohol and tobacco consumption and breast cancer were collated, checked and analysed centrally. Analyses included 58515 women with invasive breast cancer and 95067 controls from 53 studies. Relative risks of breast cancer were estimated, after stratifying by study, age, parity and, where appropriate, women's age when their first child was born and consumption of alcohol and tobacco. The average consumption of alcohol reported by controls from developed countries was 6.0 g per day, i.e. about half a unit/drink of alcohol per day, and was greater in ever-smokers than never-smokers, (8.4 g per day and 5.0 g per day, respectively). Compared with women who reported drinking no alcohol, the relative risk of breast cancer was 1.32 (1.19 - 1.45, P < 0.00001) for an intake of 35 - 44 g per day alcohol, and 1.46 (1.33 - 1.61, P < 0.00001) for greater than or equal to 45 g per day alcohol. The relative risk of breast cancer increased by 7.1% (95% CI 5.5-8.7%; P<0.00001) for each additional 10 g per day intake of alcohol, i.e. for each extra unit or drink of alcohol consumed on a daily basis. This increase was the same in ever-smokers and never-smokers (7.1 % per 10 g per day, P < 0.00001, in each group). By contrast, the relationship between smoking and breast cancer was substantially confounded by the effect of alcohol. When analyses were restricted to 22 255 women with breast cancer and 40 832 controls who reported drinking no alcohol, smoking was not associated with breast cancer (compared to never-smokers, relative risk for ever-smokers= 1.03, 95% CI 0.98 - 1.07, and for current smokers=0.99, 0.92 - 1.05). The results for alcohol and for tobacco did not vary substantially across studies, study designs, or according to 15 personal characteristics of the women; nor were the findings materially confounded by any of these factors. If the observed relationship for alcohol is causal, these results suggest that about 4% of the breast cancers in developed countries are attributable to alcohol. In developing countries, where alcohol consumption among controls averaged only 0.4 g per day, alcohol would have a negligible effect on the incidence of breast cancer. In conclusion, smoking has little or no independent effect on the risk of developing breast cancer; the effect of alcohol on breast cancer needs to be interpreted in the context of its beneficial effects, in moderation, on cardiovascular disease and its harmful effects on cirrhosis and cancers of the mouth, larynx, oesophagus and liver. (C) 2002 Cancer Research UK.
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- Barnekow-Bergkvist, Margareta, et al.
(författare)
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Prediction of development of fatigue during a simulated ambulance work task from physical performance tests.
- 2004
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Ingår i: Ergonomics. - : Informa UK Limited. - 0014-0139 .- 1366-5847. ; 47:11, s. 1238-1250
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Tidskriftsartikel (refereegranskat)abstract
- The aims of this study were (1) to identify which physical performance tests could best explain the development of fatigue during a simulated ambulance work task, (2) to investigate the effect of height and weight and (3) to investigate in what respects these findings differ between female and male ambulance personnel. Forty-eight male and 17 female ambulance personnel completed a test battery assessing cardio-respiratory capacity, muscular strength and endurance, and co-ordination. The subjects also completed a simulated ambulance work task -- carrying a loaded stretcher. The work task was evaluated by development of fatigue. Univariate and multiple regression analyses were used to investigate to what extent the tests in the test battery were able to explain the variance of developed fatigue. The explained variance was higher for female than for male ambulance personnel (time > 70% of HRpeak: R2 = 0.75 vs 0.10, accumulated lactate: R2 = 0.62 vs 0.42, perceived exertion: R2 = 0.75 vs 0.10). Significant predictors in the models were VO2max, isometric back endurance, one-leg rising, isokinetic knee flexion and shoulder extension strength. Height, but not weight, could further explain the variance. The high physical strain during carrying the loaded stretcher implies the importance of investigating whether improved performance, matching the occupational demands, could decrease the development of fatigue during strenuous tasks.
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- Bergkvist, Göran, et al.
(författare)
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Control of Elymus repens by rhizome fragmentation and repeated mowing in a newly established white clover sward
- 2017
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Ingår i: Weed research (Print). - : Blackwell Publishing Ltd. - 0043-1737 .- 1365-3180. ; 57:3, s. 172-181
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Tidskriftsartikel (refereegranskat)abstract
- Control of perennial weeds, such as Elymus repens, generally requires herbicides or intensive tillage. Alternative methods, such as mowing and competition from subsidiary crops, provide less efficient control. Fragmenting the rhizomes, with minimal soil disturbance and damage to the main crop, could potentially increase the efficacy and consistency of such control methods. This study's aim was to investigate whether fragmenting the rhizomes and mowing enhance the control of E. repens in a white clover sward. Six field experiments were conducted in 2012 and 2013 in Uppsala, Sweden, and Ås, Norway. The effect of cutting slits in the soil using a flat spade in a 10 × 10 cm or 20 × 20 cm grid and the effect of repeated mowing were investigated. Treatments were performed either during summer in a spring-sown white clover sward (three experiments) or during autumn, post-cereal harvest, in an under-sown white clover sward (three experiments). When performed in autumn, rhizome fragmentation and mowing reduced E. repens shoot biomass, but not rhizome biomass or shoot number. In contrast, when performed in early summer, rhizome fragmentation also reduced the E. repens rhizome biomass by up to 60%, and repeated mowing reduced it by up to 95%. The combination of the two factors appeared to be additive. Seasonal differences in treatment effects may be due to rhizomes having fewer stored resources in spring than in early autumn. We conclude that rhizome fragmentation in a growing white clover sward could reduce the amount of E. repens rhizomes and that repeated mowing is an effective control method, but that great seasonal variation exists. © 2017 The Authors.
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