| 1. |
- Andersson, Henric, 1963-
(författare)
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Aircraft Systems Modeling : Model Based Systems Engineering in Avionics Design and Aircraft Simulation
- 2009
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Aircraft developers like other development and manufacturing companies, are experiencing increasing complexity in their products and growing competition in the global market. One way to confront the challenges is to make the development process more efficient and to shorten time to market for new products/variants by using design and development methods based on models. Model Based Systems Engineering (MBSE) is introduced to, in a structured way, support engineers with aids and rules in order to engineer systems in a new way.In this thesis, model based strategies for aircraft and avionics development are studied. A background to avionics architectures and in particular Integrated Modular Avionics is described. The integrating discipline Systems Engineering, MBSE and applicable standards are also described. A survey on available and emerging modeling techniques and tools, such as Hosted Simulation, is presented and Modeling Domains are defined in order to analyze the engineering environment with all its vital parts to support an MBSE approach.Time and money may be saved by using modeling techniques that enable understanding of the engineering problem, state-of-the-art analysis and team communication, with preserved or increased quality and sense of control. Dynamic simulation is an activity increasingly used in aerospace, for several reasons; to prove the product concept, to validate stated requirements, and to verify the final implementation. Simulation is also used for end-user training, with specialized training simulators, but with the same underlying models. As models grow in complexity, and the set of simulation platforms is expanded, new needs for specification, model building and configuration support arise, which requires a modeling framework to be efficient.
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| 2. |
- Berglund, Emelie, et al.
(författare)
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Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity
- 2018
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Intra-tumor heterogeneity is one of the biggest challenges in cancer treatment today. Here we investigate tissue-wide gene expression heterogeneity throughout a multifocal prostate cancer using the spatial transcriptomics (ST) technology. Utilizing a novel approach for deconvolution, we analyze the transcriptomes of nearly 6750 tissue regions and extract distinct expression profiles for the different tissue components, such as stroma, normal and PIN glands, immune cells and cancer. We distinguish healthy and diseased areas and thereby provide insight into gene expression changes during the progression of prostate cancer. Compared to pathologist annotations, we delineate the extent of cancer foci more accurately, interestingly without link to histological changes. We identify gene expression gradients in stroma adjacent to tumor regions that allow for re-stratification of the tumor microenvironment. The establishment of these profiles is the first step towards an unbiased view of prostate cancer and can serve as a dictionary for future studies.
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| 3. |
- Oliaei, Erfan, 1991-
(författare)
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Lignocellulose Biocomposites– A Comparison of Wood Fibers and Microfibrillated Lignocellulose
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- All-lignocellulose composites, meaning densified fiber or fibril materials without added binder, show interesting mechanical properties and can be eco-friendly. Composites based on hot-pressed microfibrillated lignocellulose (MFLC) and lignocellulosic wood fiber (WF) reinforcements are compared with respect to processing, structure, mechanical properties, and eco-indicators. Also, these reinforcements are compared in hot-pressed degradable lignocellulosic crosslinked polycaprolactone (c-PCL) biocomposites based on in-situ polymerization of new caprolactone oligomers.The intermediate lignin content (≈11%) was favorable for MFLC preparation, although the cumulative energy demand was high for mechanical disintegration from unbleached softwood kraft pulp. The mechanical properties were much better for random-in-plane MFLC compared with WF composites due to lower porosity, better interfiber bonding, and smaller-scale defects. Data for strain-field development during tensile tests was in support of these findings. For c-PCL biocomposites, much higher ultimate strength was obtained for the c-PCL/MFLC composites compared with c-PCL/WF. The most important reason was the strainhardening behavior combined with higher strain to failure, since the scale of developing defects was much smaller with MFLC reinforcement.
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