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- Marincevic-Zuniga, Yanara, et al.
(författare)
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Transcriptome sequencing in pediatric acute lymphoblastic leukemia identifies fusion genes associated with distinct DNA methylation profiles
- 2017
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Ingår i: Journal of Hematology & Oncology. - : Springer Science and Business Media LLC. - 1756-8722. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Background: Structural chromosomal rearrangements that lead to expressed fusion genes are a hallmark of acute lymphoblastic leukemia (ALL). In this study, we performed transcriptome sequencing of 134 primary ALL patient samples to comprehensively detect fusion transcripts. Methods: We combined fusion gene detection with genome-wide DNA methylation analysis, gene expression profiling, and targeted sequencing to determine molecular signatures of emerging ALL subtypes. Results: We identified 64 unique fusion events distributed among 80 individual patients, of which over 50% have not previously been reported in ALL. Although the majority of the fusion genes were found only in a single patient, we identified several recurrent fusion gene families defined by promiscuous fusion gene partners, such as ETV6, RUNX1, PAX5, and ZNF384, or recurrent fusion genes, such as DUX4-IGH. Our data show that patients harboring these fusion genes displayed characteristic genome-wide DNA methylation and gene expression signatures in addition to distinct patterns in single nucleotide variants and recurrent copy number alterations. Conclusion: Our study delineates the fusion gene landscape in pediatric ALL, including both known and novel fusion genes, and highlights fusion gene families with shared molecular etiologies, which may provide additional information for prognosis and therapeutic options in the future.
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- Norberg, Lisbet, et al.
(författare)
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Methane and Nitrous oxide production from agricultural peat soils in relation to drainage level and abiotic and biotic factors
- 2021
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Ingår i: Frontiers in Environmental Science. - : Frontiers Media SA. - 2296-665X. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Greenhouse gas emissions from drained agricultural peatlands contribute significantly to global warming. In a laboratory study using intact cores of peat soil from eight different sites in Sweden, factors controlling the emission of the greenhouse gases nitrous oxide (N2O) and methane (CH4) were examined. Soil properties, and the abundance of the total microbial community (16S rRNA gene abundance), and genes encoding for functions controlling N2O emissions (bacterial and archaeal amoA, nirS, nirK, nosZI, and nosZII) were analyzed and compared against measured greenhouse gas emissions. Emissions were measured at different drainage levels, i.e., higher soil water suction values, since drainage is an important factor controlling greenhouse gas emissions from peat soils. The results showed that N2O and CH4 emissions were generally low, except for N2O emissions at near water-saturated conditions, for which three soils displayed high values and large variations in fluxes. Relationships between N2O emissions and soil properties were mainly linked to soil pH, with higher emissions at lower pH. However, specific assemblages of nitrogen cycling guilds that included nosZII, typically present in non-denitrifying N2O reducers, were detected in soils with low N2O emissions. Overall, these results indicate that both pH and biotic controls determine net N2O fluxes.
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- Ahnesjö, Ingrid, et al.
(författare)
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En beteende-ekologisk forskningsperiod på Klubbans biologiska station : Rapport från återträff med Doktorer som disputerade (1983-2001) på avhandlingar med fältarbete på Klubbans Biologiska station. I en värld av kantnålar, stubbar, spiggar och nudingar.
- 2018
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Rapport (populärvet., debatt m.m.)abstract
- We had the fortune as PhD-students and scientists in Animal Ecology at Uppsala University, to spend joyful and creative field work summers at Klubban Biological Station, during the 1980-90’s. A reunion in June 2018 resulted in this report highlighting research on pipefishes, gobies, sticklebacks and nudibranchs. Our research on these animals have provided novel insights and knowledge of the process of sexual selection and paternal care. These animals have, in many aspects, now become model organisms in evolutionary behavioral ecology in marine environments. Our list of publications provides many examples of how environmental factors influence how sexual selection and mate choice operate, how predictors like potential reproductive rates, operational sex ratios work and how male parental care is prominent in influencing selection. This research, that started at Klubban, has broadened our understanding of the ecological importance of shallow marine areas. The evolutionary understanding of how males and females can behave and how adaptive traits are selected in interaction with social and an increasingly changing ambient environment is in focus in our continued scientific endeavors. We have happily compiled this report illustrating how science and scientist can stimulate each other at a wonderful place like Klubban Biological Station, with the access to amazing organisms like pipefishes, gobies, sticklebacks and nudibranchs.
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- Almasi, Alexandra Maria, et al.
(författare)
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Cirkulära plastgolv
- 2020
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport redovisar resultat från projektet Cirkulära plastgolv, som pågick från november 2019 till februari 2020. Syftet med projektet var att identifiera en möjlig avsättning för det plastmaterial som samlas in genom systemet GBR Golvåtervinning, men inte återvinns av golvtillverkare. Ett annat syfte har varit att öka medvetenheten bland offentliga aktörer om insamlingssystemet och hur de kan bidra till att det används i större utsträckning.
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- Almasi, Alexandra Maria, et al.
(författare)
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Guide till upphandlare: Minska klimatpåverkan genom att ställa krav på insamling av plastgolv
- 2020
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Byggsektorn har stor klimatpåverkan, men den kan minska genom ökad återvinning av avfallet. Plast är bland det byggavfall som återvinns minst. Det går att förändra genom att göra rätt redan vid upphandlingen. Denna guide är framtagen inom projektet Cirkulära plastgolv, som finansieras av Naturvårdsverket, och riktar sig till offentliga beställare. Den innehåller handfasta tips om hur man ställer krav vid upphandlingen av plastgolv för att spillet från installationen ska samlas in genom de återvinningssystem som finns.
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- Andersson, Lenastina, et al.
(författare)
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Mälsåker Revisited: Museum och Iscensättning. : Kungl Konsthögskolan. Restaureringskonst 2015-2016
- 2016
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Rapport (populärvet., debatt m.m.)abstract
- Rapporten redovisar arbeten från kursen Restaureringskonst på Konsthögskolan som under läsåret 2015-2016 har arbetat med tema Museum och Iscensättning. Hur kulturmiljöer påverkas när de blir museum, hur man restaurerar för museum, hur man bevarar och utvecklar en plats för kunskapsutbyte, bildning och upplevelser. Mälsåkers slott, utanför Mariefred, förvaltat av Statens Fastighetsverk, var studieobjekt för 20 studenter, (yrkesverksamma arkitekter, antikvarier, ingenjörer, konservatorer m fl) där utbildningens olika studiemoment som uppmätning, inventering, dokumentation har tillämpats. Fältarbetet har följts av studier i historik, kulturhistorisk värdering och analyser som gett visioner och gestaltningsförslag på ny verksamhet i slottet. Rapporten presenterar förslagen, med text, skisser, foton och ritningar. Fyra olika typer av museum med varierande grad av åtgärder, förändringar och utveckling av slottet. Restaureringsexperiment redovisas utifrån traditionella och digitala dokumentationsmetoder. Dessutom finns arbeten om barockens ljus, bladguld, brandskydd, pod-radio, kraftstation, engelska parken, dekorationsmålade tak, Gustavianum, Julius Kronbergs ateljé och barockträdgård m m. Förslagen visar att det är möjligt att transformera Mälsåkers barockslott till ett museum av idag med bibehållen historik och synliga tidslager.
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- Andersson, Sara, et al.
(författare)
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The mixed blessing of responsibility relief: An application to household recycling and curbside waste collection
- 2023
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Ingår i: Frontiers in Environmental Economics. - : Frontiers Media S.A.. - 2813-2823. ; 1
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Tidskriftsartikel (refereegranskat)abstract
- This paper addresses the role of personal norms and warm glow in influencing households' waste recycling preferences. The purpose is to explore inter-household differences in the preferences toward the introduction of curbside recycling, which implies that households are relieved from the responsibility of transporting sorted waste to assigned drop-off stations. The main theoretical point of departure for the analysis is an existing model that integrates norm-motivated behavior into neoclassical utility theory. This builds on the assumption that the household members have preferences for upholding a self-image as responsible—norm-compliant—persons, and it also contains a warm-glow component. The empirical investigation relies on a postal survey to households in a Swedish municipality, and this asks households about their willingness-to-pay (WTP) for the introduction of a curbside recycling scheme, as well as about time use and the presence of personal norms and warm glow motives. The results are based on a Heckman selection specification and show that individuals expressing a strong personal norm for recycling are more likely to be willing to pay for curbside recycling, while those with strong warm glow motives are less likely to do so. This suggests the existence of a mixed blessing of responsibility relief. Curbside recycling implies that households are relieved from a moral responsibility that takes time away from leisure activities, but they also experience a loss in warm glow as such a scheme removes the possibility to pursue something that they have learned to appreciate. There could then exist ‘motivational inertia' making it difficult for policy makers to activate personal norms for new pro-environmental household activities in replacement of existing ones.
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