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Sökning: WFRF:(Bergroth M.)

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  • Bergroth, T., et al. (författare)
  • Selection of drug-resistant HIV-1 during the early phase of viral decay is uncommon in treatment-naive patients initiated on a three- or four-drug antiretroviral regimen including lamivudine
  • 2009
  • Ingår i: Journal of medical virology. - : Wiley. - 1096-9071 .- 0146-6615. ; 81:1, s. 1-8
  • Tidskriftsartikel (refereegranskat)abstract
    • Therapy failure due to drug resistance development is a common phenomenon in HIV-infected patients. However, when the drug pressure leads to the earliest selection of drug-resistant HIV-1 populations is still unclear. In this study, the extent to which selection of the HIV-1 reverse transcriptase M184I/V mutations occur during the initial phase of viral decay in treatment-naive HIV-1 infected patients receiving antiretroviral therapy (ART) was examined. Plasma virus from three cohorts of treatment-naive patients initiating quadruple (n = 43), triple (n = 14) or dual (n = 15) lamivudine-containing ART were analyzed for M184I/V during the first 6 months of therapy using direct sequencing and a sensitive selective real-time PCR method. Among quadruple ART patients, who all were treated at primary HIV-1 infection, only one patient developed M184V after 6 weeks of therapy, having had wild-type virus at baseline. No mutations were found in chronically infected patients on triple ART. In patients on dual therapy, M184I/V mutants were found frequently. Selection of M184I/V mutants was found to be rare during the initial phase of viral decay after initiation of ART in adherent patients given a three or four-drug combination, in contrast to those receiving a less potent regimen. The results suggest that triple and quadruple lamivudine + PI or PI/r containing ART given to treatment-naive adherent patients is potent enough to prevent development of resistance during the first months of therapy.
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  • Hedekvist, Per Olof, et al. (författare)
  • Fiber Optic Time Transfer from UTC(k) to a VLBI Antenna in a Coherent Communication Network
  • 2022
  • Ingår i: 2022 Joint Conference of the European Frequency and Time Forum and IEEE International Frequency Control Symposium, EFTF/IFCS 2022 - Proceedings. - : Institute of Electrical and Electronics Engineers Inc.. - 9781665497183
  • Konferensbidrag (refereegranskat)abstract
    • The local time scale at Onsala Space Observatory is connected to UTC(SP) through a White Rabbit time transfer system operating on the Swedish University Computer Network SUNET. The time transfer enables a robust synchronization of the VLBI and the IGS stations operating at the observatory and can potentially improve the reliability and availability of traceable time at sufficient accuracy. Several months of data are gathered to evaluate long term events and stability metrics. 
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  • Resultat 1-8 av 8

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