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- Manukyan, Levon, et al.
(författare)
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Developmental exposure to a very low dose of bisphenol A induces persistent islet insulin hypersecretion in Fischer 344 rat offspring
- 2019
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Ingår i: Environmental Research. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 0013-9351 .- 1096-0953. ; 172, s. 127-136
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Tidskriftsartikel (refereegranskat)abstract
- Background: In children with obesity, accentuated insulin secretion has been coupled with development of type 2 diabetes mellitus (T2DM). Bisphenol A (BPA) is a chemical with endocrine- and metabolism-disrupting properties which can be measured in a majority of the population. Exposure to BPA has been associated with the development of metabolic diseases including T2DM.Objective: The aim of this study was to investigate if exposure early in life to an environmentally relevant low dose of BPA causes insulin hypersecretion in rat offspring.Methods: Pregnant Fischer 344 rats were exposed to 0.5 (BPA0.5) or 50 (BPA50) jig BPA/kg BW/day via drinking water from gestational day 3.5 until postnatal day 22. Pancreata from dams and 5- and 52-week-old offspring were procured and islets were isolated by collagenase digestion. Glucose-stimulated insulin secretion and insulin content in the islets were determined by ELISA.Results: Basal (5.5 mM glucose) islet insulin secretion was not affected by BPA exposure. However, stimulated (11 mM glucose) insulin secretion was enhanced by about 50% in islets isolated from BPA0.5-exposed 5- and 52 week-old female and male offspring and by 80% in islets from dams, compared with control. In contrast, the higher dose, BPA50, reduced stimulated insulin secretion by 40% in both 5- and 52-week-old female and male offspring and dams, compared with control.Conclusion: A BPA intake 8 times lower than the European Food Safety Authority's (EFSA's) current tolerable daily intake (TDI) of 4 mu g/kg BW/day of BPA delivered via drinking water during gestation and early development causes islet insulin hypersecretion in rat offspring up to one year after exposure. The effects of BPA exposure on the endocrine pancreas may promote the development of metabolic disease including T2DM.
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| 2. |
- Norberg, Astrid, et al.
(författare)
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A model of consolation
- 2001
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Ingår i: Nursing Ethics. - : SAGE Publications. - 0969-7330 .- 1477-0989. ; 8:6, s. 544-553
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Tidskriftsartikel (refereegranskat)abstract
- Consolation is needed when a human being suffers (i.e. feels alienated from him- or herself, from other people, from the world or from his or her ultimate source of meaning). The aim of this study was to illuminate the meaning of consolation. Tape-recorded narrative interviews were carried out with 18 professionals from various spheres. The transcribed interviews were interpreted hermeneutically. A model of consolation is outlined in a drawing. It states that the mediator and the receiver of consolation must become ready for consolation before it can take place. To be ready means to be present and available. Availability means expressing suffering and listening respectively, and thereby opening up for communion and consoling dialogue. Communion brings about contact with the sacred dimension that human beings share and thus with goodness, light, joy, beauty and life. Consolation involves a shift of perspective and an experience of meaning in spite of suffering.
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| 3. |
- Pehrson Berger, Ingela, et al.
(författare)
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TEMA: Gränsöverskridande i och kring litteraturen
- 2005
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Detta första nummer av Institutionen för Humanioras nya skriftserie innehåller följande bidrag:Ingela Pehrson Berger: "Ge mig din mänsklighet". Om gränserna och 'mellanrummet' som tema i Kerstin Ekmans romaner Guds barmhärtighet och Sista rompanBirgitta Bergsten: Överskrida gränser - är det tillåtet? Två litterära svenska exempelHans Färnlöf: Inre och yttre sfärer - gränsöverskridandets problematik i Tecknet av MaupassantSture Packalén: Zum Eigenen und Fremden bei Erich Fried und Peter WeissPetra Thore: Den tyskspråkiga migrantlitteraturen - begreppsdiskussion och reception under tre decennierMonica Loeb: Chappaquiddick Engendered: Joyce Carol Oates Lends a Voice to The Dead in Black WaterKarin Molander Danielsson: Detektivserien, en genre under utvecklingTommy Öberg: Paul Auster and Intertextuality - The Influence of Film Noir in GhostsAnette Månsson: Kung Oidipus av Egypten: dramatiskt möte mellan västerländska och österländska litterära traditioner i Tawfiq al Hakims Al-Malik Oudib
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