| 1. |
- Clark, Andrew G., et al.
(författare)
-
Evolution of genes and genomes on the Drosophila phylogeny
- 2007
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
-
Tidskriftsartikel (refereegranskat)abstract
- Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
|
|
| 2. |
- Lindblad-Toh, Kerstin, et al.
(författare)
-
Genome sequence, comparative analysis and haplotype structure of the domestic dog.
- 2005
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 438:7069, s. 803-19
-
Tidskriftsartikel (refereegranskat)abstract
- Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.
|
|
| 3. |
- Berlin, Cecilia, et al.
(författare)
-
Keyword mingling workshop : a method for identifying and consolidating industrially perceived needs and requirements of future operators
- 2012
-
Ingår i: Swedish Production Symposium, SPS12. - 9789175197524
-
Konferensbidrag (refereegranskat)abstract
- Investments into the technology of the future require a firm basis in the needs of production industry. However, gathering, sorting and ranking cross-industrial future needs remains a steep challenge to technology developers. Gathering feedback from just one or a few case companies can result in a biased set of priorities, since feedback from specific industrial sectors may often be highly influenced by their industry- and product-specific challenges. The workshop method presented in this paper resolves this by using a highly interactive "mingling" technique to get participants in a large group workshop (between 15 - 20 people) to answer a specific question. The participants discuss ideas in smaller groups, share their findings to the group at large, co-operatively organize the input from all participants into functional categories, and finally perform a 'ranking' of the results. The outcome is a prioritized list of concerns to focus research efforts on, providing workshop analysts with a finished structure for reporting the results. The method was tested in two workshops within the project "The Operator of the Future" and resulted in plenty of positive feedback from participants, who felt that the input was relevant, well-structured, and easy to agree with due to the consensus categorizing.
|
|
| 4. |
- Berlin, Cecilia, 1981, et al.
(författare)
-
Keyword Mingling workshop - a method for identifying and consolidating industrially perceived needs and requirements of future operators
- 2012
-
Ingår i: Swedish Production Symposium, SPS12. - 9789175197524
-
Konferensbidrag (refereegranskat)abstract
- Investments into the production technology of the future require a firm basis in the needsof production industry. However, gathering, sorting and ranking cross-industrial futureneeds remains a steep challenge to technology developers. Gathering feedback from justone or a few case companies can result in a biased set of priorities, since feedback fromspecific industrial sectors may often be highly influenced by their industry- and productspecificchallenges. This paper describes a structured method called “Keyword Mingling”that addresses the collection of such feedback in a multi-partner workshop format.The workshop method presented in this paper resolves this by using a highly interactive"mingling" technique to get participants in a large group workshop (between 15 - 20people) to answer a specific question. The participants discuss ideas in smaller groups,share their findings to the group at large, co-operatively organize the input from allparticipants into functional categories, and finally perform a 'ranking' of the results. Theoutcome is a prioritized list of concerns to focus research efforts on, providing workshopanalysts with a finished structure for reporting the results. The method was tested in twoworkshops within the project "The Operator of the Future" and resulted in plenty ofpositive feedback from participants, who felt that the input was relevant, well-structured,and easy to agree with due to the consensus categorizing.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Berlin, Lisa, et al.
(författare)
-
Response inhibition, hyperactivity, and conduct problems among preschool children
- 2002
-
Ingår i: Journal of clinical child and adolescent psychology. - 1537-4416. ; 31:2, s. 242-251
-
Tidskriftsartikel (refereegranskat)abstract
- Investigated the relation among response inhibition, hyperactivity, and conduct problems in a nonclinical sample of 115 preschool children, using 2 different types of go/no-go tasks well as a Stroop-like task. In line with the assumption that hyperactivity is related to disinhibition, the results showed that it was the measures of response inhibition, and not other performance measures, that were related to teacher ratings of hyperactivity. There was also a significant relation between response inhibition and conduct problems. Interestingly, the correlation between response inhibition and conduct problems was not significant when partialling out the effect of hyperactivity, whereas the correlation between inhibition and hyperactivity did remain significant when controlling for conduct problems. Although the association between inhibition, hyperactivity, and conduct problems appeared to be partly different for boys and girls, these differences were not statistically significant.
|
|
| 8. |
|
|
| 9. |
- Berlin, Lisa, 1973-
(författare)
-
The Role of Inhibitory Control and Executive Functioning in Hyperactivity/ADHD
- 2003
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis examined inhibition, executive functioning and their possible relation to childhood problems of hyperactivity and inattention, in its clinical form referred to as Attention Deficit Hyper-activity Disorder (ADHD). Concurrent as well as longitudinal relations were of interest, and both clinical and non-clinical samples were studied. Study I demonstrated concurrent relations between executive inhibition and both hyperactivity and conduct problems in preschool. However, the relation between inhibition and conduct problems could be attributed to the large overlap between hyperactivity and conduct problems.In Study II, linear relations were found between executive inhibition and hyperactivity, whereas inhibition to the unfamiliar was related to hyperactivity, social initiative, as well as social anxiety. Non-linear analyses showed that children with high levels of both types of inhibition were at risk for developing low social initiative and social anxiety, whereas children with low levels of inhibition were at risk for developing hyperactivity, but at the same time protected from social anxiety. In Study III, executive inhibition was longitudinally related to ADHD symptoms in both school and at home for boys, but only in the school context for girls. Executive inhibition was also related to more general executive functioning deficits, and concurrent relations were found between executive functioning and ADHD symptoms, although in both cases only for boys. Inhibition and executive functioning made independent contributions to the understanding of ADHD symptoms for boys, and together explained about half the variance in inattention problems. In Study IV, group differences were found between ADHD children and controls for both inhibition and various other executive function measures. These measures also discriminated well between groups. The best model, which included measures tapping inhibition, working memory and emotion regulation, classified 86% of the children correctly. In summary, the results of the present thesis were mostly supportive of Barkley’s hybrid model of ADHD, although it should be noted that the question of whether inhibition should be regarded as primary to other executive functions requires further investigation.
|
|
| 10. |
- Berlin, Marie, et al.
(författare)
-
The relation between out-of-home care, early school failure, and premature mortality : a 30-year follow-up of people treated for substance misuse in Sweden
- 2021
-
Ingår i: Nordic Social Work Research. - 2156-857X .- 2156-8588. ; 11:4, s. 374-386
-
Tidskriftsartikel (refereegranskat)abstract
- Evidence from Swedish and international studies show that a high proportion of children from out-of-home care (OHC) have poor school performance and that this is strongly associated with their substantial risk of adverse development in future life. However, risk factors for poor school performance and adverse development are difficult to disentangle since they are often interrelated and enforce each other over the life course. This study examines premature mortality in relation to early school failure (drop-out from compulsory school) and OHC experience in childhood (0–17 years of age) among clients who were in treatment for substance misuse in the early 1980s (N = 1,036). The analyses were based on record linkages between interview data collected during treatment and national register data covering approximately 30 years of follow-up, from exit from treatment until 2013. Our results showed that 54 per cent had been placed in OHC as children, half before their teens and half as teenagers. The OHC population had a higher prevalence of school failure compared with clients who had not been exposed to childhood OHC. OHC was associated with an excess mortality, although this was only significant for females who had entered OHC before their teens. Adjusting results for school failure reduced their excess mortality by half, and additional life course factors associated with mortality among people with substance misuse adjusted for most of the remaining excess mortality. School failure was strongly associated with the excess mortality of females, but not with the excess mortality of males.
|
|
