| 1. |
- Uhlén, Mathias, et al.
(författare)
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The human secretome
- 2019
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Ingår i: Science Signaling. - : American Association for the Advancement of Science (AAAS). - 1945-0877 .- 1937-9145. ; 12:609
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Tidskriftsartikel (refereegranskat)abstract
- The proteins secreted by human cells (collectively referred to as the secretome) are important not only for the basic understanding of human biology but also for the identification of potential targets for future diagnostics and therapies. Here, we present a comprehensive analysis of proteins predicted to be secreted in human cells, which provides information about their final localization in the human body, including the proteins actively secreted to peripheral blood. The analysis suggests that a large number of the proteins of the secretome are not secreted out of the cell, but instead are retained intracellularly, whereas another large group of proteins were identified that are predicted to be retained locally at the tissue of expression and not secreted into the blood. Proteins detected in the human blood by mass spectrometry-based proteomics and antibody-based immuno-assays are also presented with estimates of their concentrations in the blood. The results are presented in an updated version 19 of the Human Protein Atlas in which each gene encoding a secretome protein is annotated to provide an open-access knowledge resource of the human secretome, including body-wide expression data, spatial localization data down to the single-cell and subcellular levels, and data about the presence of proteins that are detectable in the blood.
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| 2. |
- Berling, Peter, et al.
(författare)
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A characterization of optimal base-stock levels for a multistage serial supply chain
- 2016
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Ingår i: Naval Research Logistics. - : Wiley. - 0894-069X .- 1520-6750. ; 63:1, s. 32-46
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Tidskriftsartikel (refereegranskat)abstract
- In this article, we present a multistage model to optimize inventory control decisions under stochastic demand and continuous review. We first formulate the general problem for continuous stages and use a decomposition solution approach: since it is never optimal to let orders cross, the general problem can be broken into a set of single-unit subproblems that can be solved in a sequential fashion. These subproblems are optimal control problems for which a differential equation must be solved. This can be done easily by recursively identifying coefficients and performing a line search. The methodology is then extended to a discrete number of stages and allows us to compute the optimal solution in an efficient manner, with a competitive complexity. (c) 2016 Wiley Periodicals, Inc. Naval Research Logistics 63: 32-46, 2016
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| 3. |
- Berling, Peter, 1973-, et al.
(författare)
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A model for heuristic coordination of real life distribution inventory systems with lumpy demand
- 2013
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Ingår i: European Journal of Operational Research. - : Elsevier BV. - 0377-2217 .- 1872-6860. ; 230:3, s. 515-526
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents an approximation model for optimizing reorder points in one-warehouse N-retailerinventory systems subject to highly variable lumpy demand. The motivation for this work stems fromclose cooperation with a supply chain management software company, Syncron International, and oneof their customers, a global spare parts provider. The model heuristically coordinates the inventory systemusing a near optimal induced backorder cost at the central warehouse. This induced backorder costcaptures the impact that a reorder point decision at the warehouse has on the retailers’ costs, and decomposesthe multi-echelon problem into solving N + 1 single-echelon problems. The decomposition frameworkrenders a flexible model that is computationally and conceptually simple enough to beimplemented in practice.A numerical study, including real data from the case company, shows that the new model performsvery well in comparison to existing methods in the literature, and offers significant improvements tothe case company. With regards to the latter, the new model in general obtains realized service levelsmuch closer to target while reducing total inventory.
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| 4. |
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| 5. |
- Berling, Peter, 1973-
(författare)
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A note generalizing "an option mechanism to coordinate a dyadic supply chain bilaterally in a multi-period setting"
- 2021
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Ingår i: Omega. - : Elsevier. - 0305-0483 .- 1873-5274. ; 101:June
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Tidskriftsartikel (refereegranskat)abstract
- The problem investigated in this paper is the one of finding the optimal combination of inventory and options in a stationary multi-period problem with an infinite horizon. The research complements existing literature as it considers the combination of option and wholesale contracts. The paper show how the problem can be transformed to a combination of newsvendor type problems. This alternative interpretation allows us to derive the necessary conditions for the pricing of an option contract that maximizes the system wide profit as well as the conditions for when the different parties will be able to design such a price scheme. It turns out that the possibility to do so depends on where it is optimal to keep inventory and how much inventory is kept under the pure wholesale contract. Moreover is it shown that the supply chain optimal solution cannot be guaranteed even if a Central planner prices the option contract.
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| 6. |
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| 7. |
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| 8. |
- Berling, Peter, et al.
(författare)
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Approximation algorithms for optimal purchase/inventory policy when purchase price and demand are stochastic
- 2014
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Ingår i: Or-Spektrum. - : Springer Science and Business Media LLC. - 0171-6468 .- 1436-6304. ; 36:4, s. 1077-1095
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Tidskriftsartikel (refereegranskat)abstract
- We consider a purchase/inventory control problem in which the purchase price and demand are stochastic, a common situation encountered by firms that replenish in a foreign currency or from commodity markets. More specifically, we assume that the demand follows a Poisson arrival process and that the log-price evolves according to a general Wiener process. Under these circumstances, the optimal policy is a state dependent base-stock policy that can be described as a series of threshold prices. An iterative procedure for determining the optimal thresholds has been derived earlier but, even for the simplest price process, the solution quickly becomes numerically intractable. To deal with this, we propose an approximation that allows us to derive simple heuristics for finding thresholds that are close to optimal. For certain price processes the heuristics are just a series of closed-form expressions. The computational complexity is reduced significantly, and the numerical study shows that the new heuristics perform considerably better than earlier suggested heuristics.
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| 9. |
- Berling, Peter, 1973-, et al.
(författare)
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Controlling inventories in omni/multi-channel distribution systems with variable customer order-sizes
- 2023
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Ingår i: Omega. - : Elsevier. - 0030-2228 .- 1541-3764 .- 0305-0483. ; 114
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Tidskriftsartikel (refereegranskat)abstract
- The fast growth of e-commerce and omni/multi-channel retailing brings new challenges for efficient inventory management. One such challenge concerns service differentiation across channels when up-stream central warehouses satisfy both direct customer demand and replenishment orders from down-stream retailers. Motivated by industry collaboration, we address this issue by developing a combined stock method for control of one-warehouse-multiple-retailer inventory systems with direct customer de-mand at the central warehouse. The combined stock method, used for service differentiation at the cen-tral warehouse, may be described as a critical level policy. The computationally efficient heuristics we present are designed to deal with real-life one warehouse multiple retailer inventory systems character-ized by highly variable customer order-sizes, ( R, Q) policies at all stock points, and fill rate constraints. A numerical study, including real data from two different companies, illustrates that the heuristics perform well; offering near optimal solutions close to target fill rates, with significant opportunities to reduce total inventory costs compared to existing methods. (c) 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
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| 10. |
- Berling, Peter, et al.
(författare)
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Demand and sales value considerations for differentiating the service levels
- 2007
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Ingår i: Presented at the 19th International NOFOMA conference, 2007.
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Konferensbidrag (refereegranskat)abstract
- How to choose the appropriate service level has been described by many authors and logistics professionals. The common basis for differentiating the policy parameters between products used by many professionals is a traditional ABC-analysis based on the sales volume in SEK, i.e. the demand times the price per unit. Even if this basis is suitable for several issues in inventory management it is not the best for differentiating the service level. This since the value of having a high service level for a high-price product is comparatively low whereas the value of having it for a high demand product is high. There hence exist arguments both for a high and a low service level for A products.The purpose of this work is to 1) estimate the potential savings from differentiating the service level 2) contribute to the understanding of which factors should be used as the base for differentiating the service level 3) develop an easy to use method for grouping the products and determining the appropriate service level for each group. In the paper we suggest a simple method for differentiating the service level using a combined ABC/XYZ analysis based on the sales volume in SEK (as the traditional method) and the demand in units. The economical benefits of the suggested method have been evaluated using numerical examples based on real life demand data. This study indicates that substantial cost benefits can be achieved compared to a system with no differentiation of the service levels.
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