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- Emilsson, Maria, et al.
(författare)
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Pedagogical challenges in nurse education : a case study focusing on the completion rate in theoretical education at a Swedish University
- 2014
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Ingår i: Empirical Research in Vocational Education and Training. - : Springer. - 1877-6337 .- 1877-6345. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Background: The purpose of this survey was to relate completion rate and results on national clinical final examinations to student’s admission background and examination results for nursing and medical courses.Methods: The research data were based on a quantitative case study, with 286 nursing students, using statistical analysis.Results: The programme's overall completion rate was 76%, i.e. almost one out of four students did not complete the programme. The higher students' upper secondary/high school grades, the fewer attempts they needed to pass the nursing and medical courses exams (p<0.001). The average examination attempts needed to pass courses in medical science was significantly greater than the number needed to pass courses in nursing science (p<0.001). In a multivariate analysis both upper secondary/high school grades and average examination attempts needed to pass were significant predictors for national clinical final examination score.Conclusion: In sum, upper secondary/high school grades and examination attempts needed, especially for courses in medical science, may be regarded as important indicators of achieved knowledge and skills which are tested in the national final examination.
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- García, Maria C, et al.
(författare)
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Mature-onset obesity in interleukin-1 receptor I knockout mice.
- 2006
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 55:5, s. 1205-13
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Tidskriftsartikel (refereegranskat)abstract
- Interleukin-1 (IL-1) is a major mediator of inflammation that exerts its biological activities through the IL-1 type I receptor (IL-1RI). The body weights of IL-1RI(-/-) mice of both sexes started to deviate from those of wild-type mice at 5-6 months of age and were 20% higher at 9 months of age. Visceral and subcutaneous fat mass, measured by dual-energy X-ray absorptiometry and magnetic resonance imaging, was markedly (1.5- to 2.5-fold) increased. Lean body mass and crown-rump length were also slightly (11 and 5%, respectively) increased, as was serum IGF-I. Obese IL-1RI(-/-) mice were insulin resistant, as evidenced by hyperinsulinemia, decreased glucose tolerance, and insulin sensitivity. To elucidate the mechanisms for the development of obesity, young pre-obese IL-1RI(-/-) mice were investigated. They showed decreased suppression of body weight and food intake in response to systemic leptin treatment. The decreased leptin responsiveness was even more pronounced in older obese animals. Moreover, spontaneous locomotor activity and fat utilization, as measured by respiratory quotient, were decreased in pre-obese IL-1RI(-/-) mice. In conclusion, lack of IL-1RI-mediated biological activity causes mature-onset obesity. This obese phenotype is preceded by decreased leptin sensitivity, fat utilization, and locomotor activity.
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- Hellberg, Victoria, et al.
(författare)
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Cisplatin and oxaliplatin toxicity : importance of cochlear kinetics as a determinant for ototoxicity
- 2009
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Ingår i: Journal of the National Cancer Institute. - Cary : Oxford University Press. - 0027-8874 .- 1460-2105. ; 101:1, s. 37-47
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Cisplatin is a cornerstone anticancer drug with pronounced ototoxicity, whereas oxaliplatin, a platinum derivative with a different clinical profile, is rarely ototoxic. This difference has not been explained.METHODS: In HCT-116 cells, cisplatin (20 microM)-induced apoptosis was reduced by a calcium chelator from 9.9-fold induction (95% confidence interval [CI] = 8.1- to 11.7-fold), to 3.1-fold induction (95% CI = 2.0- to 4.2-fold) and by superoxide scavenging from 9.3-fold (95% CI = 8.8- to 9.8-fold), to 5.1-fold (95% CI = 4.4- to 5.8-fold). A guinea pig model (n = 23) was used to examine pharmacokinetics. Drug concentrations were determined by liquid chromatography with post-column derivatization. The total platinum concentration in cochlear tissue was determined by inductively coupled plasma mass spectrometry. Drug pharmacokinetics was assessed by determining the area under the concentration-time curve (AUC). Statistical tests were two-sided.RESULTS: In HCT-116 cells, cisplatin (20 microM)-induced apoptosis was reduced by a calcium chelator from 9.9-fold induction (95% confidence interval [CI] = 8.1- to 11.7-fold to 3.1-fold induction) (95% CI = 2.0- to 4.2-fold) and by superoxide scavenging (from 9.3-fold, 95% CI = 8.8- to 9.8-fold, to 5.1-fold, 95% CI = 4.4- to 5.8-fold). Oxaliplatin (20 microM)-induced apoptosis was unaffected by calcium chelation (from 7.1- to 6.2-fold induction) and by superoxide scavenging (from 5.9- to 5.6-fold induction). In guinea pig cochlea, total platinum concentration (0.12 vs 0.63 microg/kg, respectively, P = .008) and perilymphatic drug concentrations (238 vs 515 microM x minute, respectively, P < .001) were lower after intravenous oxaliplatin treatment (16.6 mg/kg) than after equimolar cisplatin treatment (12.5 mg/kg). However, after a non-ototoxic cisplatin dose (5 mg/kg) or the same oxaliplatin dose (16.6 mg/kg), the AUC for perilymphatic concentrations was similar, indicating that the two drugs have different cochlear pharmacokinetics.CONCLUSION: Cisplatin- but not oxaliplatin-induced apoptosis involved superoxide-related pathways. Lower cochlear uptake of oxaliplatin than cisplatin appears to be a major explanation for its lower ototoxicity.
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- Berndtsson, Joakim, 1975, et al.
(författare)
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Private Security and the Public–Private Divide: Contested Lines of Distinction and Modes of Governance in the Stockholm-Arlanda Security Assemblage
- 2011
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Ingår i: International Political Sociology. - 1749-5687. ; 2011:5, s. 408-425
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Tidskriftsartikel (refereegranskat)abstract
- The increasing privatization of security and the changing patterns of security governance call into question the foundational lines of demar- cation between the ‘‘public’’ and ‘‘private.’’ This article investigates how key actors in the security assemblage at Stockholm-Arlanda Airport make sense of their roles in relation to public–private distinctions. While central to the ways in which security actors understand them- selves and each other, closer inspection reveals that the drawing of these lines is also highly ambivalent and contested—in relation to questions of control and regulation, authority, as well as security rationalities. Further, ‘‘private–private’’ and ‘‘public–public’’ contesta- tions also are informed by the obdurate public–private distinction.
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| 9. |
- Berndtsson, Joakim, 1975, et al.
(författare)
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Private Security Guards: Authority, Control and Governance?
- 2016
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Ingår i: Routledge Handbook of Private Security Studies (eds. Rita Abrahamsen and Anna Leander). - London and New York : Routledge. - 9780415729352 ; , s. 51-61
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Berndtsson, Joakim, 1975, et al.
(författare)
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Sweden: public servants from the private sector
- 2013
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Ingår i: Commercialising security in Europe : political consequences for peace and reconciliation operations / edited by Anna Leander.. - London : Routledge. - 9780415509893 ; , s. 58-79
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Bokkapitel (refereegranskat)
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