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- Abe, K., et al.
(författare)
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J-PARC Neutrino Beamline Upgrade Technical Design Report
- 2019
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Rapport (refereegranskat)abstract
- In this document, technical details of the upgrade plan of the J-PARC neutrino beamline for the extension of the T2K experiment are described. T2K has proposed to accumulate data corresponding to 2×1022 protons-on-target in the next decade, aiming at an initial observation of CP violation with 3σ or higher significance in the case of maximal CP violation. Methods to increase the neutrino beam intensity, which are necessary to achieve the proposed data increase, are described.
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| 5. |
- Boyle, P, et al.
(författare)
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Need for global action for cancer control
- 2008
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Ingår i: Annals of oncology : official journal of the European Society for Medical Oncology. - : Elsevier BV. - 1569-8041. ; 19:9, s. 1519-1521
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Bylander, Jonas, 1978, et al.
(författare)
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Pulse imaging and nonadiabatic control of solid-state artificial atoms
- 2009
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Ingår i: Physical Review B - Condensed Matter and Materials Physics. - 2469-9950 .- 2469-9969. ; 80:22, s. 220506-
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Tidskriftsartikel (refereegranskat)abstract
- Transitions in an artificial atom, driven nonadiabatically through an energy-level avoided crossing, can be controlled by carefully engineering the driving protocol. We have driven a superconducting persistent-current qubit with a large-amplitude radio-frequency field. By applying a biharmonic wave form generated by a digital source, we demonstrate a mapping between the amplitude and phase of the harmonics produced at the source and those received by the device. This allows us to image the actual wave form at the device. This information is used to engineer a desired time dependence, as confirmed by the detailed comparison with a simulation. © 2009 The American Physical Society.
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| 7. |
- Makusa, Gregory Paul, et al.
(författare)
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Freeze-thaw cycling and the hydraulic conductivity of geosynthetic clay liners concurrent with cation exchange
- 2014
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Ingår i: Canadian geotechnical journal (Print). - : Canadian Science Publishing. - 0008-3674 .- 1208-6010. ; 51:6, s. 591-598
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Tidskriftsartikel (refereegranskat)abstract
- Tests were conducted to assess the effect of cation exchange coincident with freeze-thaw cycling on the hydraulic conductivity of a geosynthetic clay liner (GCL). GCLs were prehydrated by contact with silica flour moistened with synthetic subgrade pore water and subsequently permeated with a solution representing the pore water in the cover soil over a tailings facility. Control tests were conducted using the same procedure except deionized water (DI) was used as the permeant liquid to preclude cation exchange from the permeant liquid. The GCLs were subjected to 1, 3, 5, 15, and 20 freeze-thaw cycles, and the hydraulic conductivity and exchange complex were determined after each freeze-thaw increment to assess chemical changes that occurred during freezing, thawing, and permeation. GCLs undergoing freeze thaw cycling experienced little to no cation exchange until 15 freeze-thaw cycles. After 20 freeze-thaw cycles, however, 50% of the sodium (Na) initially in the exchange complex was replaced by calcium (Ca). Dissolution of calciate within the bentonite is a likely source of the Ca. Hydraulic conductivity of GCLs exposed to freeze-thaw cycling was lower than the hydraulic conductivity of a new GCL permeated with DI water (< 2.2x10-11 m/s). A small increases in hydraulic conductivity (~2.3 times), which may have been caused by cation exchange, occured at 15 and 20 freeze-thaw cycles but the hydraulic conductivity remained below that obtained by direct permeation with DI water.
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| 8. |
- Oberst, Simon, et al.
(författare)
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Strategies to decrease inequalities in cancer therapeutics, care and prevention
- 2024
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Ingår i: Molecular Oncology. - : Wiley-Blackwell. - 1878-0261 .- 1574-7891. ; 18:2, s. 245-279
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Analyses of inequalities related to prevention and cancer therapeutics/care show disparities between countries with different economic standing, and within countries with high Gross Domestic Product. The development of basic, technological and biological research provides clinical and prevention opportunities that make their implementation into healthcare systems more complex, mainly due to the growth of Personalized/Precision Cancer Medicine (PCM). Initiatives like the US‐Cancer Moonshot and the EU‐Mission on Cancer and Europe´s Beating Cancer Plan are initiated to boost cancer prevention and therapeutics/care innovation and to mitigate present inequalities. The conference organised by the Pontifical Academy of Sciences in collaboration with the European Academy of Cancer Sciences discussed the inequality problem, dependent on the economic status of a country, the increasing demands for infrastructure supportive of innovative research and its implementation in healthcare and prevention programs. Establishing translational research and a coherent cancer research continuum is still a challenge. Research has to cover the entire continuum from basic to outcomes research for clinical and prevention components. Comprehensive Cancer Centres (CCCs) are of critical importance for integrating research innovations to preclinical and early clinical research, as for ensuring state‐of‐the‐art patient care within healthcare systems. International collaborative networks between CCCs are necessary to reach the critical mass of infrastructures and patients for PCM research, and for introducing prevention modalities and new treatments effectively. Outcomes and health economics research are required to assess the cost‐effectiveness of new interventions, currently a missing element in the research portfolio. Data sharing and critical mass are essential for innovative research to develop PCM. Despite advances in cancer research, cancer incidence and prevalence is growing. Making cancer research infrastructures accessible for all patients, considering the increasing inequalities, requires science policy actions incentivising research aimed at prevention and cancer therapeutics/care with an increased focus on patients´ needs and cost‐effective healthcare.
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