| 1. |
- Benlloch, Jose M., et al.
(författare)
-
The MINDVIEW project : First results
- 2018
-
Ingår i: European psychiatry. - : Cambridge University Press (CUP). - 0924-9338 .- 1778-3585. ; 50, s. 21-27
-
Tidskriftsartikel (refereegranskat)abstract
- We present the first results of the MINDVIEW project. An innovative imaging system for the human brain examination, allowing simultaneous acquisition of PET/MRI images, has been designed and constructed. It consists of a high sensitivity and high resolution PET scanner integrated in a novel, head-dedicated, radio frequency coil for a 3T MRI scanner. Preliminary measurements from the PET scanner show sensitivity 3 times higher than state-of-the-art PET systems that will allow safe repeated studies on the same patient. The achieved spatial resolution, close to 1 mm, will enable differentiation of relevant brain structures for schizophrenia. A cost-effective and simple method of radiopharmaceutical production from 11C-carbon monoxide and a mini-clean room has been demonstrated. It has been shown that 11C-raclopride has higher binding potential in a new VAAT null mutant mouse model of schizophrenia compared to wild type control animals. A significant reduction in TSPO binding has been found in gray matter in a small sample of drug-naïve, first episode psychosis patients, suggesting a reduced number or an altered function of immune cells in brain at early stage schizophrenia.
|
|
| 2. |
- Bonnetain, Franck, et al.
(författare)
-
Guidelines for time-to-event end-point definitions in trials for pancreatic cancer : Results of the DATECAN initiative (Definition for the Assessment of Time-to-event End-points in CANcer trials)
- 2014
-
Ingår i: European Journal of Cancer. - : Elsevier BV. - 0959-8049 .- 1879-0852. ; 50:17, s. 2983-2993
-
Forskningsöversikt (refereegranskat)abstract
- Background: Using potential surrogate end-points for overall survival (OS) such as Disease-Free- (DFS) or Progression-Free Survival (PFS) is increasingly common in randomised controlled trials (RCTs). However, end-points are too often imprecisely defined which largely contributes to a lack of homogeneity across trials, hampering comparison between them. The aim of the DATECAN (Definition for the Assessment of Time-to-event End-points in CANcer trials)-Pancreas project is to provide guidelines for standardised definition of time-to-event end-points in RCTs for pancreatic cancer. Methods: Time-to-event end-points currently used were identified from a literature review of pancreatic RCT trials (2006-2009). Academic research groups were contacted for participation in order to select clinicians and methodologists to participate in the pilot and scoring groups (>30 experts). A consensus was built after 2 rounds of the modified Delphi formal consensus approach with the Rand scoring methodology (range: 1-9). Results: For pancreatic cancer, 14 time to event end-points and 25 distinct event types applied to two settings (detectable disease and/or no detectable disease) were considered relevant and included in the questionnaire sent to 52 selected experts. Thirty experts answered both scoring rounds. A total of 204 events distributed over the 14 end-points were scored. After the first round, consensus was reached for 25 items; after the second consensus was reached for 156 items; and after the face-to-face meeting for 203 items. Conclusion: The formal consensus approach reached the elaboration of guidelines for standardised definitions of time-to-event end-points allowing cross-comparison of RCTs in pancreatic cancer.
|
|
| 3. |
- Fergelot, Patricia, et al.
(författare)
-
Phenotype and genotype in 52 patients with Rubinstein–Taybi syndrome caused by EP300 mutations
- 2016
-
Ingår i: American Journal of Medical Genetics. Part A. - : Wiley. - 1552-4825 .- 1552-4833. ; 170:12, s. 3069-3082
-
Tidskriftsartikel (refereegranskat)abstract
- Rubinstein–Taybi syndrome (RSTS) is a developmental disorder characterized by a typical face and distal limbs abnormalities, intellectual disability, and a vast number of other features. Two genes are known to cause RSTS, CREBBP in 60% and EP300 in 8–10% of clinically diagnosed cases. Both paralogs act in chromatin remodeling and encode for transcriptional co-activators interacting with >400 proteins. Up to now 26 individuals with an EP300 mutation have been published. Here, we describe the phenotype and genotype of 42 unpublished RSTS patients carrying EP300 mutations and intragenic deletions and offer an update on another 10 patients. We compare the data to 308 individuals with CREBBP mutations. We demonstrate that EP300 mutations cause a phenotype that typically resembles the classical RSTS phenotype due to CREBBP mutations to a great extent, although most facial signs are less marked with the exception of a low-hanging columella. The limb anomalies are more similar to those in CREBBP mutated individuals except for angulation of thumbs and halluces which is very uncommon in EP300 mutated individuals. The intellectual disability is variable but typically less marked whereas the microcephaly is more common. All types of mutations occur but truncating mutations and small rearrangements are most common (86%). Missense mutations in the HAT domain are associated with a classical RSTS phenotype but otherwise no genotype–phenotype correlation is detected. Pre-eclampsia occurs in 12/52 mothers of EP300 mutated individuals versus in 2/59 mothers of CREBBP mutated individuals, making pregnancy with an EP300 mutated fetus the strongest known predictor for pre-eclampsia.
|
|
| 4. |
- Forssén, Jens, 1968, et al.
(författare)
-
Toolbox from the EC FP7 HOSANNA project for the reduction of road and rail traffic noise in the outdoor environment
- 2014
-
Ingår i: Transport Research Arena 2014, Paris, France. ; , s. 10-
-
Konferensbidrag (refereegranskat)abstract
- This paper offers a brief overview of innovative methods for road and rail traffic noise reduction between sourceand receiver. These include using new barrier designs, planting of trees, treatments of ground and road surfacesand greening of building façades and roofs using natural materials, like vegetation, soil and other substrates incombination with recycled materials and artificial elements. The abatements are assessed in terms of numericallypredicted sound level reductions, perceptual effects and cost–benefit analysis. Useful reductions of noise fromurban roads and tramways are predicted for 1-m-high urban noise barriers and these are increased by addinginter-lane barriers. A 3 m wide 0.3 m high lattice ground treatment, a carefully planted 15-m-wide tree belt andreplacing 50 m of paved areas by grassland are predicted to give similar reductions. Tree belts are shown to bevery cost-effective and combining tall barriers with a row of trees reduces the negative impact of wind. Greenroofs may significantly reduce the noise at the quiet side of buildings.
|
|
| 5. |
- Forssén, Jens, 1968, et al.
(författare)
-
Åtgärder i utomhusmiljön för att minska buller från väg- och tågtrafik – resultat från EU-projektet HOSANNA
- 2013
-
Ingår i: LjudBladet, Svenska akustiska sällskapet. - 1403-2317. ; 3, s. 16-28
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Denna artikel ger en kort översikt av bulleråtgärder, resulterande från EU-projektet HOSANNA, för minskning av buller från väg- och spårtrafik under ljudets utbredning. Dessa verktyg inkluderar användning av ny skärmdesign, plantering av träd, förbättringar av mark- och vägytor samt vegetation på byggnadsfasader och tak, med hjälp av naturmaterial, såsom vegetation, jord och andra substrat i kombination med återvunnet material och artificiella element. De akustiska insättningsdämpningarna bedöms genom numeriska beräkningar, perceptuella effekter och kostnadsnyttoanalys. En betydande minskning av buller från väg- och spårtrafik förutsägs för ett 1-m-högt urbant bullerskydd. Detta kan förbättras, upp till ca 10 dB insättningsdämpning, genom att placera ytterligare skydd mellan körfälten. Ett 3 m brett och 0,3 m högt rutnät, ett omsorgsfullt planterat 15 m brett trädbälte samt att ersätta 50 meter asfalterad mark med gräsmark förutspås ge bullerminskningar om 5–8 dB, medan användning av fasadvegetation och gröna tak kan minska nivån på innergårdar med upp till ca 4 respektive 7 dB. Trädbälten visar sig vara mycket kostnadseffektiva och kombinationer av höga skärmar med en rad av träd minskar de negativa effekterna av vind på bullerskärmars insättningsdämpning. Gröna tak kan minska bullret på den tysta sidan av byggnader.
|
|
| 6. |
- Nilsson, Mats E., et al.
(författare)
-
Perceptual effects of noise mitigation
- 2014
-
Ingår i: Environmental Methods for Transport Noise Reduction. - : CRC Press. - 9780415675239 ; , s. 195-219
-
Bokkapitel (refereegranskat)abstract
- Noise mitigation reduces the audibility of a noise source at the location of the receiver, making the source less annoying and less likely to interfere with activities, such as sleep, rest, and speech. Many mitigation methods change temporal and spectral properties of noise, which may influence perceived annoyance, over and above the effect related to the overall reduction in A-weighted sound pressure level. Noise reduction also may increase the noticeability of other sources, which may influence the perception of the overall acoustic environment. Finally, well-designed noise mitigation solutions may improve the visual environment, e.g., a vegetated noise barrier or earth berm can visually shield the traffic and increase the amount of visible greenery. This chapter provides examples of such perceptual effects of noise mitigation, from effects on perception of the noise itself, via effects on the soundscape, to potential effects on the overall audio-visual environment.
|
|
| 7. |
- Nilsson, Mats, et al.
(författare)
-
NOVEL SOLUTIONS FOR QUIETER AND GREENER CITIES
- 2013
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This brochure summarizes the main findings of the research project “HOlistic and Sustainable Abatement of Noise by optimized combinations of Natural and Artificial means” (HOSANNA). The project aimed to develop a toolbox for reducing road and rail traffic noise in outdoor environments by the optimal use of vegetation, soil, other natural materials and recycled materials in combination with artificial elements.
|
|
