| 1. |
- Ahlberg, Mats Steinholtz, et al.
(författare)
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PCASTt/SPCG-17-A randomised trial of active surveillance in prostate cancer: Rationale and design
- 2019
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Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Introduction Overtreatment of localised prostate cancer is substantial despite increased use of active surveillance. No randomised trials help define how to monitor patients or when to initiate treatment with curative intent. Methods and analysis A randomised, multicentre, intervention trial designed to evaluate the safety of an MRI-based active surveillance protocol, with standardised triggers for repeated biopsies and radical treatment. The aim is to reduce overtreatment of prostate cancer. 2000 men will be randomly allocated to either surveillance according to current practice or to standardised triggers at centres in Sweden, Norway, Finland and the UK. Men diagnosed in the past 12 months with prostate cancer, ≤T2a, prostate-specific antigen (PSA) <15 ng/mL, PSA density ≤0.2 ng/mL/cc, any International Society of Urological Pathology (ISUP) grade 1 are eligible. Men with ISUP grade 2 in <30% of cores on systematic biopsy and <10 mm cancer in one core on systematic or targeted biopsy are also eligible. Men diagnosed on systematic biopsy should have an MRI and targeted biopsies against Prostate Imaging and Reporting Data System V.2 3-5 lesions before inclusion. Identical follow-up in the two study arms: biannual PSA testing, yearly clinical examination and MRI every second year. In the experimental arm, standardised triggers based on MRI and PSA density elicit repeated biopsies. MRI and histopathological progression trigger radical treatment. Primary outcome measure is progression-free survival. Secondary outcome measures are cumulative incidence of metastatic disease, treatments with curative intent, pT3-4 at radical prostatectomy, switch to watchful waiting, prostate cancer mortality and quality of life. Inclusion started in October 2016 and in October 2018; 275 patients have been enrolled. Ethics and dissemination Ethical approval was obtained in each participating country. Results for the primary and secondary outcome measures will be submitted for publication in peer-reviewed journals. Trial registration number NCT02914873.
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| 2. |
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| 3. |
- Mattsson, Claes, 1978-, et al.
(författare)
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Design of a Micromachined Thermopile Infrared Sensor with a Self-Supported SiO2/SU-8 Membrane
- 2008
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Ingår i: IEEE Sensors Journal. - Piscataway, USA : IEEE. - 1530-437X .- 1558-1748. ; 8:12, s. 2044-2052
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Tidskriftsartikel (refereegranskat)abstract
- In the infrared region of the spectrum thermoelectric detectors such as the thermopile, are extensively used. These detectors rely on the well-known Seebeck effect, in which there is a direct conversion of thermoelectric differentials into electrical voltage. The temperature difference over thermocouple junctions is in general, created by forming a thin membrane connected to the silicon bulk. In many existing thermopiles, materials such as Si and Si3N4 have been used as membrane. These materials suffer from relatively high thermal conductivity, which lowers the membrane temperature and reduces the sensitivity of the detector. A material such as SU-8 2002 has a much lower thermal conductivity and is applied using standard photolithographic processing steps. This work presents thermal simulations regarding the use of SU-8 2002 as a thermal insulating membrane as compared to Si and Si3N4. The simulation results presented show that the temperature increase in a 5 µm SiO2/SU-8 membrane is about 9% higher than in a 1 µm Si3N4 membrane, despite the membrane thickness being increased by a factor of 5. A thermopile consisting of 196 serially interconnected Ti/Ni thermocouples positioned on a 5 µm SiO2/SU-8 2002 membrane has been fabricated. The sensitivity of the fabricated device has been evaluated in the infrared region, using a 1.56 µm IR laser and a xenon arc lamp together with a monochromator. The measurement results show a sensitivity of approximately 5 V/W over the wavelength range between 900 - 2200 nm. Measurements performed in a vacuum chamber show that the sensitivity of the detector could be increased by more than a factor of 3 by mounting the detector in a vacuum sealed capsule.
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| 4. |
- Mattsson, Claes, et al.
(författare)
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Development of an infrared thermopile detector with a thin self-supporting SU-8 membrane
- 2007
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Ingår i: Proceedings of IEEE Sensors. - New York : IEEE conference proceedings. - 9781424412624 ; , s. 836-839
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Konferensbidrag (refereegranskat)abstract
- In this paper we present the development and characterization of thermopile detector on a 4 mum thin self-supporting membrane made of the epoxy based photoresist SU-8. The membrane is realized using silicon bulk micromachining techniques. In many existing thermopile detectors, a temperature difference over the thermocouple junctions is achieved by connecting a thin membrane of either Si or Si3N4 to a silicon bulk. These materials suffer from relatively high thermal conductivity, which lowers the sensitivity of the detector. A material such as SU-8 has much lower thermal conductivity and is applied using standard photolithographic processing steps. Simulation results are presented which verifies SU-8 as a better choice than Si and Si3N4 when used as thermal insulating membrane in a thermopile detector. A thermopile consisting of 196 series coupled Ti/Ni thermocouples has been fabricated. Results from measurements are presented, showing a sensitivity of 5.6 V/W and a noise equivalent power (NEP) of 9.9 nW/radicHz.
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| 5. |
- Mattsson, Claes, 1978-, et al.
(författare)
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Fabrication and characterization of a design optimized SU-8 thermopile with enhanced sensitivity
- 2009
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Ingår i: Measurement science and technology. - : IOP. - 0957-0233 .- 1361-6501. ; 20:11, s. 115202-
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Tidskriftsartikel (refereegranskat)abstract
- In the infrared wavelength region, thermopiles are an important type of detectors. A major advantage of thermopiles is their non-cooling requirement. Depending on the applied absorption layer, their responsivity is often rather flat within a large wavelength region. This work presents the fabrication and characterization of a sensitivity and design optimized thermopile detector with a 4 µm self-supported SiO2/SU-8 membrane. The structure consists of 240 series interconnected thermocouple junctions obtained by a metal evaporation and lift-off. Two metal combinations have been evaluated, namely, nickel/titanium and aluminium/bismuth. Series resistances of 76 k and 283 k were measured for the Ni/Ti thermopile and the Al/Bi thermopile respectively. For the Al/Bi thermopile a responsivity of 60 V/W was achieved using a 1.56 µm fibre coupled diode laser with a power of 3.5 mW. Using a white light source with a radiation flux of 0.45 W/mm2 a voltage response of 68 V mm2/W was measured for the Al/Bi thermopile. The time constant of the characterized detectors was calculated as being 70 ms, using the pulsed IR laser.
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| 6. |
- Mattsson, Claes, et al.
(författare)
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Fabrication and evaluation of a thermal sensor formed on a thin photosensitive epoxy membrane with low thermal conductivity
- 2008
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Ingår i: PROCEEDINGS OF THE 17TH INTERNATIONAL VACUUM CONGRESS/13TH INTERNATIONAL CONFERENCE ON SURFACE SCIENCE/INTERNATIONAL CONFERENCE ON NANOSCIENCE AND TECHNOLOGY. - : Institute of Physics (IOP). ; , s. 082048-
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Konferensbidrag (refereegranskat)abstract
- This article present the fabrication and development of a thin metal film bolometer IR detector connected in a Wheatstone bridge configuration. The bolometer is constructed on a 4 μm thin self-supported SU-8 2002 membrane. A polymer material such as SU-8 has low thermal conductivity and is applied using standard photolithographic processing step, and this could increase detector sensitivity and lower the production cost. Thermal simulation results are presented, which verifies SU-8 as a better choice of materials compared to common membrane materials such as Si and Silicon nitride. Measurements on the fabricated nickel resistance bolometer on SU-8 2002 membrane show a sensitivity of 9.3 V/W when radiated by an IR laser with a wavelength of 1.56 μm.
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| 7. |
- Mattsson, Claes, 1978-, et al.
(författare)
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Thermal simulation and design optimization of a thermopile infrared detector with SU-8 membrane
- 2009
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Ingår i: Journal of Micromechanics and Microengineering. - : IOP Publishing. - 0960-1317 .- 1361-6439. ; 19:5, s. 055016-
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Tidskriftsartikel (refereegranskat)abstract
- Simulation and optimization tools are commonly used in the design phase of advanced electronics devices. In this work, we present a thermal simulation and design optimization tool for infrared thermopile detectors based on a closed membrane structure. The tool can be used to simulate and optimize thermopile detectors with an arbitrary number of design parameters. The optimization utilizes the Nelder–Mead and the adaptive simulated annealing optimization algorithms to maximize the system performance. A thermopile detector with an SU-8-based closed membrane and metal–metal thermocouples has been simulated and optimized. Based on the results generated by the tool, an optimized detector has been fabricated and characterized. The results from the measurements presented are in good agreement with the simulation results.
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| 8. |
- Ambatipudi, Radhika, 1982-
(författare)
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High Frequency (MHz) Planar Transformers for Next Generation Switch Mode Power Supplies
- 2013
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Increasing the power density of power electronic converters while reducing or maintaining the same cost, offers a higher potential to meet the current trend inrelation to various power electronic applications. High power density converters can be achieved by increasing the switching frequency, due to which the bulkiest parts, such as transformer, inductors and the capacitor's size in the convertercircuit can be drastically reduced. In this regard, highly integrated planar magnetics are considered as an effective approach compared to the conventional wire wound transformers in modern switch mode power supplies (SMPS). However, as the operating frequency of the transformers increase from several hundred kHz to MHz, numerous problems arise such as skin and proximity effects due to the induced eddy currents in the windings, leakage inductance and unbalanced magnetic flux distribution. In addition to this, the core losses whichare functional dependent on frequency gets elevated as the operating frequency increases. Therefore, this thesis provides an insight towards the problems related to the high frequency magnetics and proposes a solution with regards to different aspects in relation to designing high power density, energy efficient transformers.The first part of the thesis concentrates on the investigation of high power density and highly energy efficient coreless printed circuit board (PCB) step-down transformers useful for stringent height DC-DC converter applications, where the core losses are being completely eliminated. These transformers also maintain the advantages offered by existing core based transformers such as, high coupling coefficient, sufficient input impedance, high energy efficiency and wide frequencyband width with the assistance of a resonant technique. In this regard, several coreless PCB step down transformers of different turn’s ratio for power transfer applications have been designed and evaluated. The designed multilayered coreless PCB transformers for telecom and PoE applications of 8,15 and 30W show that the volume reduction of approximately 40 - 90% is possible when compared to its existing core based counterparts while maintaining the energy efficiency of the transformers in the range of 90 - 97%. The estimation of EMI emissions from the designed transformers for the given power transfer application proves that the amount of radiated EMI from a multilayered transformer is lessthan that of the two layered transformer because of the decreased radius for thesame amount of inductance.The design guidelines for the multilayered coreless PCB step-down transformer for the given power transfer application has been proposed. The designed transformer of 10mm radius has been characterized up to the power level of 50Wand possesses a record power density of 107W/cm3 with a peak energy efficiency of 96%. In addition to this, the design guidelines of the signal transformer fordriving the high side MOSFET in double ended converter topologies have been proposed. The measured power consumption of the high side gate drive circuitvitogether with the designed signal transformer is 0.37W. Both these signal andpower transformers have been successfully implemented in a resonant converter topology in the switching frequency range of 2.4 – 2.75MHz for the maximum load power of 34.5W resulting in the peak energy efficiency of converter as 86.5%.This thesis also investigates the indirect effect of the dielectric laminate on the magnetic field intensity and current density distribution in the planar power transformers with the assistance of finite element analysis (FEA). The significanceof the high frequency dielectric laminate compared to FR-4 laminate in terms of energy efficiency of planar power transformers in MHz frequency region is also explored.The investigations were also conducted on different winding strategies such as conventional solid winding and the parallel winding strategies, which play an important role in the design and development of a high frequency transformer and suggested a better choice in the case of transformers operating in the MHz frequency region.In the second part of the thesis, a novel planar power transformer with hybrid core structure has been designed and evaluated in the MHz frequency region. The design guidelines of the energy efficient high frequency planar power transformerfor the given power transfer application have been proposed. The designed corebased planar transformer has been characterized up to the power level of 50W and possess a power density of 47W/cm3 with maximum energy efficiency of 97%. This transformer has been evaluated successfully in the resonant converter topology within the switching frequency range of 3 – 4.5MHz. The peak energy efficiency ofthe converter is reported to be 92% and the converter has been tested for the maximum power level of 45W, which is suitable for consumer applications such as laptop adapters. In addition to this, a record power density transformer has been designed with a custom made pot core and has been characterized in thefrequency range of 1 - 10MHz. The power density of this custom core transformer operating at 6.78MHz frequency is 67W/cm3 and with the peak energy efficiency of 98%.In conclusion, the research in this dissertation proposed a solution for obtaining high power density converters by designing the highly integrated, high frequency(1 - 10MHz) coreless and core based planar magnetics with energy efficiencies inthe range of 92 - 97%. This solution together with the latest semiconductor GaN/SiC switching devices provides an excellent choice to meet the requirements of the next generation ultra flat low profile switch mode power supplies (SMPS).
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| 9. |
- Andersson, Henrik, et al.
(författare)
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Processing and Characterization of a MOS Type Tetra Lateral Position Sensitive Detector with Indium Tin Oxide Gate Contact
- 2008
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Ingår i: IEEE Sensors Journal. - 1530-437X .- 1558-1748. ; 8:9-10, s. 1704-1709
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Tidskriftsartikel (refereegranskat)abstract
- A 2-D tetra lateral position sensitive detector (PSD) based on the metal-oxide-semiconductor (MOS) principle has been manufactured and characterized. The active area of the device is 5 nun x 5 mm and the intention is to use the central 4 nun x 4 nun for low nonlinearity measurements. The gate contact is made of indium tin oxide (ITO) that is a degenerate electrically conducting semiconductor, which, in addition, is also transparent in the visible part of the spectrum. The use of a MOS structure results in a processing with no necessity to use implantation or diffusion in order to make the resistive p-layer as in a conventional p-n junction lateral effect PSD. Position measurements show good linearity in the middle 4 nun x 4 mm area. Within the middle 2.1 mm x 2.1 mm, the nonlinearity is within 1.7% of the active area with a position detection error of maximum 60 mu m. Measured MOS IV characteristics are compared to a level 3 spice model fit and show good agreement. The threshold voltage is determined to be -0.03 V. Responsivity measurements show a high sensitivity in the visible spectral region.
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| 10. |
- Bergman, Gunnar, et al.
(författare)
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Antiplasticization and transition to marked nonlinear viscoelasticity in poly(vinyl chloride)/acrylonitrile–butadiene copolymer blends
- 1977
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Ingår i: Journal of Applied Polymer Science. - : Wiley. - 0021-8995 .- 1097-4628. ; 21:11, s. 2953-2961
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Tidskriftsartikel (refereegranskat)abstract
- A series of PVC/NBR blends with varying acrylonitrile (AN) content in the NBR has been studied in uniaxial tension creep tests. The tests have been carried out at 21.5 ± 0.5°C covering creep times from 10 to 1000 sec. NBR with low AN content, having poor compatibility with PVC, gives the blends with higher compliance and increased time dependence of the compliance. A higher AN content in the NBR gives the blends with the opposite properties when the NBR is added in small amounts. NBR with 40 wt‐% AN is found to act as an antiplasticizer giving minimal creep compliance when 7 wt‐% NBR is added. The antiplasticization reveals a considerably increased stress level at which the transition from approximatively linear to marked nonlinear viscoelasticity occurs and a decreased stress dependence of the creep compliance in the nonlinear viscoelastic range. Since the antiplasticization is also associated with a suppression of the β‐transition mechanism, the results provide a demonstration of the importance of β‐mechanism in the stress activated processes responsible for the appearance of nonlinear viscoelasticity in solid polymers.
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