| 1. |
- Luo, Yifei, et al.
(författare)
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Technology Roadmap for Flexible Sensors
- 2023
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Ingår i: ACS Nano. - : American Chemical Society. - 1936-0851 .- 1936-086X. ; 17:6, s. 5211-5295
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Forskningsöversikt (refereegranskat)abstract
- Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative efforts, scientific breakthroughs can be made sooner and capitalized for the betterment of humanity.
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| 2. |
- Datta-Chaudhuri, Timir, et al.
(författare)
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The Fourth Bioelectronic Medicine Summit "Technology Targeting Molecular Mechanisms" : current progress, challenges, and charting the future
- 2021
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Ingår i: Bioelectronic medicine. - : BioMed Central. - 2332-8886. ; 7:1
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- There is a broad and growing interest in Bioelectronic Medicine, a dynamic field that continues to generate new approaches in disease treatment. The fourth bioelectronic medicine summit "Technology targeting molecular mechanisms" took place on September 23 and 24, 2020. This virtual meeting was hosted by the Feinstein Institutes for Medical Research, Northwell Health. The summit called international attention to Bioelectronic Medicine as a platform for new developments in science, technology, and healthcare. The meeting was an arena for exchanging new ideas and seeding potential collaborations involving teams in academia and industry. The summit provided a forum for leaders in the field to discuss current progress, challenges, and future developments in Bioelectronic Medicine. The main topics discussed at the summit are outlined here.
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| 3. |
- Mora, Camilo, et al.
(författare)
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Broad threat to humanity from cumulative climate hazards intensified by greenhouse gas emissions
- 2018
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Ingår i: Nature Climate Change. - : Springer Science and Business Media LLC. - 1758-678X .- 1758-6798. ; 8:12, s. 1062-1071
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Tidskriftsartikel (refereegranskat)abstract
- The ongoing emission of greenhouse gases (GHGs) is triggering changes in many climate hazards that can impact humanity. We found traceable evidence for 467 pathways by which human health, water, food, economy, infrastructure and security have been recently impacted by climate hazards such as warming, heatwaves, precipitation, drought, floods, fires, storms, sea-level rise and changes in natural land cover and ocean chemistry. By 2100, the world’s population will be exposed concurrently to the equivalent of the largest magnitude in one of these hazards if emmisions are aggressively reduced, or three if they are not, with some tropical coastal areas facing up to six simultaneous hazards. These findings highlight the fact that GHG emissions pose a broad threat to humanity by intensifying multiple hazards to which humanity is vulnerable.
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| 4. |
- Seitanidou, Maria, 1985-
(författare)
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Overcoming Limitations of Iontronic Delivery Devices
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Organic electronic devices are considered as one of the best candidates to replace conventional inorganic electronic devices due to their electronic conductive functionality, low-cost production techniques, the ability to tune their optical and electronic properties using organic chemistry, and their mechanical flexibility. Moreover, these systems are ideal for bioelectronic applications due to their softness, biocompatibility, and most importantly, their electronic and ionic transport. Indeed, these materials are compatible with biological tissues and cells improving the signal transduction between electronic devices and electrically excitable cells. As ions serve as one of the primary signal carriers of cells, they can selectively tune a cell’s activity; therefore, an improved interface between electronics and biological systems can offer several advantages in healthcare, e.g. the development of efficient drug delivery devices. The main focus of this thesis is the development of electronic delivery devices. Electrophoretic delivery devices called organic electronic ion pumps (OEIPs) are used to electronically control the delivery of small ions, neurotransmitters, and drugs with high spatiotemporal resolution. This work elucidates the ion transport processes and phenomena that happen in the ion exchange membranes during ion delivery and clarifies which parameters are crucial for the ion transport efficiency of the OEIPs. This thesis shows a systematic investigation of these parameters and indicates new methods and OEIP designs to overcome these challenges. Two novel OEIP designs are developed and introduced in this thesis to improve the local ion transport while limiting side effects. OEIPs based on palladium proton trap contacts can improve the membrane permselectivity and optimize the delivery of γ-aminobutyric acid (GABA) neurotransmitters at low pH while preventing any undesired pH changes from proton transport in the biological systems. And OEIPs based on glass capillary fibers are developed to overcome the limitations of devices on planar substrates, related to more complex and larger biologically relevant ion delivery with low mobility for implantable applications. This design can optimize the transport of ions and drugs such as salicylic acid (SA) at low concentrations and at relatively much higher rates, thereby addressing a wider range of biomedically relevant applications and needs.
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