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- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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2. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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- Dankiewicz, Josef, et al.
(författare)
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Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest
- 2021
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Ingår i: New England Journal of Medicine. - : MASSACHUSETTS MEDICAL SOC. - 0028-4793 .- 1533-4406. ; 384:24, s. 2283-2294
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Tidskriftsartikel (refereegranskat)abstract
- Hypothermia or Normothermia after Cardiac Arrest This trial randomly assigned patients with coma after out-of-hospital cardiac arrest to undergo targeted hypothermia at 33 degrees C or normothermia with treatment of fever. At 6 months, there were no significant between-group differences regarding death or functional outcomes. Background Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence is of low certainty. Methods In an open-label trial with blinded assessment of outcomes, we randomly assigned 1900 adults with coma who had had an out-of-hospital cardiac arrest of presumed cardiac or unknown cause to undergo targeted hypothermia at 33 degrees C, followed by controlled rewarming, or targeted normothermia with early treatment of fever (body temperature, >= 37.8 degrees C). The primary outcome was death from any cause at 6 months. Secondary outcomes included functional outcome at 6 months as assessed with the modified Rankin scale. Prespecified subgroups were defined according to sex, age, initial cardiac rhythm, time to return of spontaneous circulation, and presence or absence of shock on admission. Prespecified adverse events were pneumonia, sepsis, bleeding, arrhythmia resulting in hemodynamic compromise, and skin complications related to the temperature management device. Results A total of 1850 patients were evaluated for the primary outcome. At 6 months, 465 of 925 patients (50%) in the hypothermia group had died, as compared with 446 of 925 (48%) in the normothermia group (relative risk with hypothermia, 1.04; 95% confidence interval [CI], 0.94 to 1.14; P=0.37). Of the 1747 patients in whom the functional outcome was assessed, 488 of 881 (55%) in the hypothermia group had moderately severe disability or worse (modified Rankin scale score >= 4), as compared with 479 of 866 (55%) in the normothermia group (relative risk with hypothermia, 1.00; 95% CI, 0.92 to 1.09). Outcomes were consistent in the prespecified subgroups. Arrhythmia resulting in hemodynamic compromise was more common in the hypothermia group than in the normothermia group (24% vs. 17%, P<0.001). The incidence of other adverse events did not differ significantly between the two groups. Conclusions In patients with coma after out-of-hospital cardiac arrest, targeted hypothermia did not lead to a lower incidence of death by 6 months than targeted normothermia. (Funded by the Swedish Research Council and others; TTM2 ClinicalTrials.gov number, .)
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6. |
- Ständer, S., et al.
(författare)
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EADV Task Force Pruritus White Paper on chronic pruritus and chronic prurigo : Current challenges and future solutions
- 2024
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Ingår i: Journal of the European Academy of Dermatology and Venereology. - 0926-9959 .- 1468-3083.
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Tidskriftsartikel (refereegranskat)abstract
- Chronic pruritus (CP) is frequent in general medicine and the most common complaint in general dermatology. The prevalence of CP is expected to rise in the future due to the ageing population. The clinical presentation, underlying aetiology and treatment strategy of CP are heterogeneous. Also, individual treatment aims and physical, psychic and economic burdens of patients might vary. Chronic prurigo (CPG) is the most severe disease in the chronic pruritus spectrum, being associated with long-standing scratch-induced skin lesions and a therapy refractory itch-scratch-cycle. It is thus important to raise disease awareness for CP and CPG in the general public and among decision-makers in the health system. Further, there is a need to support a rational clinical framework to optimize both diagnostics and therapeutics. Currently, there is still a shortcoming regarding approved therapies and understanding CP/CPG as severe medical conditions. Therefore, the EADV Task Force Pruritus decided to publish this white paper based on several consensus meetings. The group consented on the following goals: (a) ensure that CP is recognized as a serious condition, (b) increase public awareness and understanding of CP and CPG as chronic and burdensome diseases that can greatly affect a person's quality of life, (c) clarify that in most cases CP and CPG are non-communicable and not caused by a psychiatric disease, (d) improve the support and treatment given to patients with CP to help them manage their disease and (e) publicize existing therapies including current guidelines. We aim to point to necessary improvements in access and quality of care directed to decision-makers in health policy, among payers and administrations as well as in practical care.
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7. |
- Bourgoin, M., et al.
(författare)
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Investigation of the small-scale statistics of turbulence in the Modane S1MA wind tunnel
- 2018
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Ingår i: CEAS Aeronautical Journal. - : Springer. - 1869-5582 .- 1869-5590. ; 9:2, s. 269-281
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Tidskriftsartikel (refereegranskat)abstract
- This article describes the planning, set-up, turbulence characterization and analysis of measurements of a passive grid turbulence experiment that was carried out in the S1MA wind-tunnel from ONERA in Modane, in the context of the ESWIRP European project. This experiment aims at a detailed investigation of the statistical properties of turbulent flows at large Reynolds numbers. The primary goal is to take advantage of the unequaled large-scale dimensions of the ONERA S1MA wind-tunnel facility, to make available to the broad turbulence community high-quality experimental turbulence data with unprecendented resolution (both spatial and temporal) and accuracy (in terms of statistical convergence). With this goal, we designed the largest grid-generated turbulence experiment planned and performed to date. Grid turbulence is a canonical flow known to produce almost perfectly homogeneous and isotropic turbulence (HIT) which remains a unique framework to investigate fundamental physics of turbulent flows. Here, we present a brief description of the measurements, in particular those based on hot-wire diagnosis. By comparing results from classical hot-wires and from a nano-fabricated wire (developed at Princeton University), we show that our goal of resolving down to the smallest dissipative scales of the flow has been achieved. We also present the full characterization of the turbulence here, in terms of turbulent energy dissipation rate, injection and dissipation scales (both spatial and temporal) and Reynolds number.
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8. |
- Jacobsen, Henrik, et al.
(författare)
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Spin dynamics of the director state in frustrated hyperkagome systems
- 2021
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Ingår i: Physical Review B. - : American Physical Society. - 2469-9969 .- 2469-9950. ; 104:5
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Tidskriftsartikel (refereegranskat)abstract
- We present an experimental study of the magnetic structure and dynamics of two frustrated hyperkagome compounds, Gd3Ga5O12 and Gd3Al5O12. It has previously been shown that Gd3Ga5O12 exhibits long-range correlations of multipolar directors that are formed from antiferromagnetic spins on loops of ten ions. Using neutron diffraction and reverse Monte Carlo simulations we prove the existence of similar magnetic correlations in Gd3Al5O12, showing the ubiquity of these complex structures in frustrated hyperkagome materials. Using inelastic neutron scattering we shed further light on the director state and the associated low-lying magnetic excitations. In addition, we have measured quasielastic dynamics that show evidence of spin diffusion. Finally, we present AC susceptibility measurements on both Gd3Ga5O12 and Gd3Al5O12, revealing a large difference in the low-frequency dynamics between the two otherwise similar compounds.
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