| 1. |
- Dinh, Thanh Theresa, et al.
(författare)
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An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression
- 2022
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Immunoglobulin family and carbohydrate vascular addressins encoded by Madcam1 and St6gal1 control lymphocyte homing into intestinal tissues, regulating immunity and inflammation. The addressins are developmentally programmed to decorate endothelial cells lining gut post-capillary and high endothelial venules (HEV), providing a prototypical example of organ- and segment-specific endothelial specialization. We identify conserved NKX-COUP-TFII composite elements (NCCE) in regulatory regions of Madcam1 and St6gal1 that bind intestinal homeodomain protein NKX2-3 cooperatively with venous nuclear receptor COUP-TFII to activate transcription. The Madcam1 element also integrates repressive signals from arterial/capillary Notch effectors. Pan-endothelial COUP-TFII overexpression induces ectopic addressin expression in NKX2-3+ capillaries, while NKX2-3 deficiency abrogates expression by HEV. Phylogenetically conserved NCCE are enriched in genes involved in neuron migration and morphogenesis of the heart, kidney, pancreas and other organs. Our results define an NKX-COUP-TFII morphogenetic code that targets expression of mucosal vascular addressins.
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| 2. |
- Zhang, Yuhan, et al.
(författare)
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Bike-sharing systems rebalancing considering redistribution proportions: A user-based repositioning approach
- 2023
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Ingår i: Physica A: Statistical Mechanics and its Applications. - : Elsevier BV. - 0378-4371. ; 610
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Tidskriftsartikel (refereegranskat)abstract
- Bike-sharing systems have become an indispensable transportation mode due to the environmental friendliness and shareability in the sustainable cities development process. However, the asymmetry of people's travel patterns during the morning and evening rush hours has contributed to the imbalance in bike inventory. Consequently, station rentals and returns require redistribution to address the rebalancing of bikes. In this paper, a user-based repositioning method through a bi-level programming model is proposed. With the objective of minimizing the repositioning workload, the upper-level model yields redistribution proportions that enable the balance between rentals and returns at the station. In addition, aiming at maximum user profit, the lower-level model calculates a redistribution matrix between station pairs and provides recommended stations for users. Finally, three levels of evaluation indicators for the bike-sharing system, operators, and users are presented. The results indicate that the proposed user-based repositioning is remarkably effective in improving the bike inventory balance and the station's turnover rate. This study provides a novel idea for the bike-sharing repositioning problem and contributes to the improvement of urban transportation.
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