| 3. |
- Minoia, F, et al.
(author)
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Dissecting the heterogeneity of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
- 2015
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In: The Journal of rheumatology. - : The Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 42:6, s. 994-1001
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Journal article (peer-reviewed)abstract
- To seek insights into the heterogeneity of macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (sJIA) through the analysis of a large patient sample collected in a multinational survey.Methods.International pediatric rheumatologists and hemato-oncologists entered their patient data, collected retrospectively, in a Web-based database. The demographic, clinical, laboratory, histopathologic, therapeutic, and outcome data were analyzed in relation to (1) geographic location of caring hospital, (2) subspecialty of attending physician, (3) demonstration of hemophagocytosis, and (4) severity of clinical course.Results.A total of 362 patients were included by 95 investigators from 33 countries. Demographic, clinical, laboratory, and histopathologic features were comparable among patients seen in diverse geographic areas or by different pediatric specialists. Patients seen in North America were given biologics more frequently. Patients entered by pediatric hemato-oncologists were treated more commonly with biologics and etoposide, whereas patients seen by pediatric rheumatologists more frequently received cyclosporine. Patients with demonstration of hemophagocytosis had shorter duration of sJIA at MAS onset, higher prevalence of hepatosplenomegaly, lower levels of platelets and fibrinogen, and were more frequently administered cyclosporine, intravenous immunoglobulin (IVIG), and etoposide. Patients with severe course were older, had longer duration of sJIA at MAS onset, had more full-blown clinical picture, and were more commonly given cyclosporine, IVIG, and etoposide.Conclusion.The clinical spectrum of MAS is comparable across patients seen in different geographic settings or by diverse pediatric subspecialists. There was a disparity in the therapeutic choices among physicians that underscores the need to establish uniform therapeutic protocols.
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| 4. |
- Souza, S. O., et al.
(author)
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Chrono-chemodynamical analysis of the globular cluster NGC 6355 : Looking for the fundamental bricks of the Bulge
- 2023
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 671
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Journal article (peer-reviewed)abstract
- The information on Galactic assembly time is imprinted on the chemodynamics of globular clusters. This makes them important probes that help us to understand the formation and evolution of the Milky Way. Discerning between in-situ and ex-situ origin of these objects is difficult when we study the Galactic bulge, which is the most complex and mixed component of the Milky Way. To investigate the early evolution of the Galactic bulge, we analysed the globular cluster NGC 6355. We derived chemical abundances and kinematic and dynamic properties by gathering information from high-resolution spectroscopy with FLAMES-UVES, photometry with the Hubble Space Telescope, and Galactic dynamic calculations applied to the globular cluster NGC 6355. We derive an age of 13:2 ± 1:1 Gyr and a metallicity of [Fe/H] =-1:39 ± 0:08 for NGC 6355, with α-enhancement of [α/Fe] = +0:37 ± 0:11. The abundance pattern of the globular cluster is compatible with bulge field RR Lyrae stars and in-situ well-studied globular clusters. The orbital parameters suggest that the cluster is currently confined within the bulge volume when we consider a heliocentric distance of 8:54 ± 0:19 kpc and an extinction coefficient of RV = 2:84 ± 0:02. NGC 6355 is highly likely to come from the main bulge progenitor. Nevertheless, it still has a low probability of being formed from an accreted event because its age is uncertain and because of the combined [Mg/Mn] [Al/Fe] abundance. Its relatively low metallicity with respect to old and moderately metal-poor inner Galaxy clusters may suggest a low-metallicity floor for globular clusters that formed in-situ in the early Galactic bulge.
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