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Sökning: WFRF:(Bijl H.)

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1.
  • Langefeld, Carl D., et al. (författare)
  • Transancestral mapping and genetic load in systemic lupus erythematosus
  • 2017
  • Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (similar to 50% of these regions have multiple independent associations); these include 24 novel SLE regions (P < 5 x 10(-8)), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SLE.
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2.
  • Blom, David S., et al. (författare)
  • A comparison of Rosenbrock and ESDIRK methods combined with iterative solvers for unsteady compressible flows
  • 2016
  • Ingår i: Advances in Computational Mathematics. - : Springer Science and Business Media LLC. - 1572-9044 .- 1019-7168. ; 42:6, s. 1401-1426
  • Tidskriftsartikel (refereegranskat)abstract
    • In this article, we endeavour to find a fast solver for finite volume discretizations for compressible unsteady viscous flows. Thereby, we concentrate on comparing the efficiency of important classes of time integration schemes, namely time adaptive Rosenbrock, singly diagonally implicit (SDIRK) and explicit first stage singly diagonally implicit Runge-Kutta (ESDIRK) methods. To make the comparison fair, efficient equation system solvers need to be chosen and a smart choice of tolerances is needed. This is determined from the tolerance TOL that steers time adaptivity. For implicit Runge-Kutta methods, the solver is given by preconditioned inexact Jacobian-free Newton-Krylov (JFNK) and for Rosenbrock, it is preconditioned Jacobian-free GMRES. To specify the tolerances in there, we suggest a simple strategy of using TOL/100 that is a good compromise between stability and computational effort. Numerical experiments for different test cases show that the fourth order Rosenbrock method RODASP and the fourth order ESDIRK method ESDIRK4 are best for fine tolerances, with RODASP being the most robust scheme.
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  • Resultat 1-4 av 4
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