| 1. |
- Hollestelle, Antoinette, et al.
(författare)
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No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer
- 2016
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Ingår i: Gynecologic Oncology. - : Elsevier BV. - 0090-8258 .- 1095-6859. ; 141:2, s. 386-401
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Tidskriftsartikel (refereegranskat)abstract
- Objective Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3′ UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370. Methods Centralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15,357 ovarian cancer patients; 30,816 controls), the Breast Cancer Association Consortium (33,530 breast cancer patients; 37,640 controls), and the Consortium of Modifiers of BRCA1 and BRCA2 (14,765 BRCA1 and 7904 BRCA2 mutation carriers). Results We found no association with risk of ovarian cancer (OR = 0.99, 95% CI 0.94-1.04, p = 0.74) or breast cancer (OR = 0.98, 95% CI 0.94-1.01, p = 0.19) and results were consistent among mutation carriers (BRCA1, ovarian cancer HR = 1.09, 95% CI 0.97-1.23, p = 0.14, breast cancer HR = 1.04, 95% CI 0.97-1.12, p = 0.27; BRCA2, ovarian cancer HR = 0.89, 95% CI 0.71-1.13, p = 0.34, breast cancer HR = 1.06, 95% CI 0.94-1.19, p = 0.35). Null results were also obtained for associations with overall survival following ovarian cancer (HR = 0.94, 95% CI 0.83-1.07, p = 0.38), breast cancer (HR = 0.96, 95% CI 0.87-1.06, p = 0.38), and all other previously-reported associations. Conclusions rs61764370 is not associated with risk of ovarian or breast cancer nor with clinical outcome for patients with these cancers. Therefore, genotyping this variant has no clinical utility related to the prediction or management of these cancers.
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| 2. |
- Atta, Khalid Tourkey, et al.
(författare)
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Phasor extremum seeking control with adaptive perturbation amplitude
- 2016
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Ingår i: 2016 IEEE 55th Conference on Decision and Control, CDC 2016. - Piscataway, NJ : Institute of Electrical and Electronics Engineers (IEEE). - 9781509018376 ; , s. 7069-7074
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Konferensbidrag (refereegranskat)abstract
- In this paper, we propose a perturbation amplitude adaption scheme for phasor extremum seeking control based on the plant's estimated gradient. By using phasor extremum seeking instead of classical extremum seeking, the problem of algebraic loops in the controller formulation is avoided. Furthermore, a stability analysis for the proposed method is provided, which is the first stability analysis for extremum seeking controllers using adaptive amplitudes. The proposed method is illustrated using numerical examples and it is found that changes in optimum can be tracked accurately while the steady-state perturbations can be reduced significantly.
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| 3. |
- Birk, Andreas, et al.
(författare)
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Planetary Exploration in USARSim : A Case Study including Real World Data from Mars
- 2009
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Ingår i: RoboCup 2008. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 9783642029202 - 3642029205 ; , s. 463-472
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Konferensbidrag (refereegranskat)abstract
- Intelligent Mobile Robots are increasingly used in unstructured domains; one particularly challenging example for this is, planetary exploration. The preparation of according missions is highly non-trivial, especially as it is difficult to carry out realistic experiments without, very sophisticated infrastructures. In this paper, we argue that, the, Unified System for Automation and Robot Simulation (USARSim) offers interesting opportunities for research on planetary exploration by mobile robots. With the example of work on terrain classification, it, is shown how synthetic as well as real world data, from Mars call be used to test an algorithm's performance in USARSim. Concretely, experiments with an algorithm for the detection of negotiable ground oil a, planetary surface are presented. It is shown that the approach performs fast; and robust on planetary surfaces.
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| 4. |
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| 5. |
- Birk, Wolfgang, et al.
(författare)
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Active safety system for a vehicle and a method for operation in an active safety system
- 2006
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Patent (populärvet., debatt m.m.)abstract
- An active safety system (10) for a vehicle comprising: - an external object sensor system (24) arranged on a host vehicle (12), said sensor system (24) being arranged to, within a detecting range (22) of said sensor system (24), sense objects (14 - 20) external to said host vehicle (12) and generate input data relating to said objects (14 - 20), wherein said input data include an object position ((R,È rel )(t)), - a threat indicator (26) which is arranged to assign a threat level (T k (t)) to each external object (k; 14 - 20) detected by the sensor system (24); and a method run in an active safety system.
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| 6. |
- Birk, Wolfgang, et al.
(författare)
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An Application Software For Visualization and Control Configuration Selection of Interconnected Processes
- 2014
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Ingår i: Control Engineering Practice. - : Elsevier BV. - 0967-0661 .- 1873-6939. ; 26, s. 188-200
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a new application software for control conguration selection of interconnected industrial processes,called ProMoVis. Moreover, ProMoVis is able to visualize process models and process layout at the physical leveltogether with the control system dynamics. The software consists of a builder part where the visual representationof the interconnected process is created and an analyzer part where the process is analyzed using dierent controlconguration selection tools.The conceptual idea of the software is presented and the subsequent design and implementation of ProMoVis isdiscussed. The implemented analysis methods are briey described including their usage and implementation aspects.The use of ProMoVis is demonstrated by an application study on the stock preparation process at SCA Obbola AB,Sweden. The results of this study are compared with the currently used control strategy.The study indicates that ProMoVis introduces a systematic and comprehensive way to perform control congurationselection. ProMoVis has been released under the Apache Open Source license.
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| 7. |
- Birk, Wolfgang, et al.
(författare)
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An object awareness determination system and a method for determining awareness of an object
- 2006
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Patent (populärvet., debatt m.m.)abstract
- An object awareness determination system comprising: - an external object sensor system (10) arranged on a host vehicle (14), said sensor system (10) being arranged to, within a detecting range (16) of said sensor system, sense objects (18) and generate input data relating to objects external to said host vehicle, wherein said input data include an object position (x,y), an object velocity ¦(x ,y )¦ and an object direction of movement ((x ,y )/¦(x ,y )¦) associated with each object in said detecting range (16), characterised in that said object awareness determination system further comprises; a controller (20) for determining awareness of the user to an object (22) that recently has entered the detecting range (16) of the external object sensor system, and a method for determining awareness of an object that recently has entered into a detecting range (16) of the external object sensor system
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| 8. |
- Birk, Wolfgang, et al.
(författare)
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Control and gas leakage detection in a fine coal injection plant : design and experiments
- 1998
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Ingår i: Automation in mining, mineral, and metal processing 1998, (MMM'98). - Oxford : Pergamon Press. ; , s. 261-266
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Konferensbidrag (refereegranskat)abstract
- This paper deals with design and implementation of a combined model-based control and gas leakage detection system applied to the pulverized coal injection plant at SSAB Tunnplåt AB in Luleå, Sweden. The structure and functions of the in-house control and process monitoring system SafePCI are described. SafePCI is experimentally tested and has successfully completed two weeks test operation. The evaluation of the test operation indicate that combined model-based control and gas leakage detection is a major improvement for control systems in the process industry.
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| 9. |
- Birk, Wolfgang, et al.
(författare)
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Implementation and industrial experiences of advanced control and monitoring in coal injection
- 2000
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Ingår i: Control Engineering Practice. - 0967-0661 .- 1873-6939. ; 8:3, s. 327-335
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Tidskriftsartikel (refereegranskat)abstract
- This paper summarizes the implementation and industrial experiences of a model-based control and gas-leakage detection system in a coal injection plant. It describes how advanced control and monitoring can be implemented in an industrial environment while taking human–machine interface aspects into consideration. The operation of the advanced and the conventional concept are compared regarding evaluation data, experiences and observations of operators and maintenance personnel. It is shown that the advanced control and monitoring system improves plant performance without disturbing routines in plant operation and, moreover, is positively accepted by the plant operators.
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| 10. |
- Birk, Wolfgang, et al.
(författare)
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Interactive modeling and visualization of complex processes in pulp and paper making
- 2010
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Konferensbidrag (refereegranskat)abstract
- This paper discusses a new approach to interactive modeling, visualization and analysis of complex industrial processes. A theoretical framework based on signal flow graphs for modeling and visualization is presented. Using this framework a software tool is designed, called ProMoVis, which can be used to model a process, to visualize the models together with process construction and control system, and to perform analysis regarding e.g. feasible control strategies for the process. Moreover, a case study is conducted, where ProMoVis is used to model, visualize and analyze a stock preparation plant. The results indicate that the proposed methods and tools improve work flows, increase process understanding and simplify decision making on control strategies for complex process.
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