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- Bennert, Vardha N., et al.
(författare)
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A Local Baseline of the Black Hole Mass Scaling Relations for Active Galaxies. IV. Correlations Between M (BH) and Host Galaxy sigma, Stellar Mass, and Luminosity
- 2021
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Ingår i: Astrophysical Journal. - : IOP Publishing Ltd. - 0004-637X .- 1538-4357. ; 921:1
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Tidskriftsartikel (refereegranskat)abstract
- The tight correlations between the mass of supermassive black holes (M (BH)) and their host-galaxy properties have been of great interest to the astrophysical community, but a clear understanding of their origin and fundamental drivers still eludes us. The local relations for active galaxies are interesting in their own right and form the foundation for any evolutionary study over cosmic time. We present Hubble Space Telescope optical imaging of a sample of 66 local active galactic nuclei (AGNs); for 14 objects, we also obtained Gemini near-infrared images. We use state-of-the-art methods to perform surface photometry of the AGN host galaxies, decomposing them into spheroid, disk, and bar (when present), and inferring the luminosity and stellar mass of the components. We combine this information with spatially resolved kinematics obtained at the Keck Telescopes to study the correlations between M (BH) (determined from single-epoch virial estimators) and host galaxy properties. The correlations are uniformly tight for our AGN sample, with intrinsic scatter 0.2-0.4 dex, smaller than or equal to that of quiescent galaxies. We find no difference between pseudo and classical bulges or barred and nonbarred galaxies. We show that all the tight correlations can be simultaneously satisfied by AGN hosts in the 10(7)-10(9) M (circle dot) regime, with data of sufficient quality. The M (BH)-sigma relation is also in agreement with that of AGN with M (BH) obtained from reverberation mapping, providing an indirect validation of single-epoch virial estimators of M (BH).
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| 2. |
- Campbell, PJ, et al.
(författare)
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Pan-cancer analysis of whole genomes
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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| 3. |
- Kelly, Patrick L., et al.
(författare)
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Constraints on the Hubble constant from supernova Refsdal's reappearance
- 2023
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Ingår i: Science. - 0036-8075 .- 1095-9203. ; 380:6649
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Tidskriftsartikel (refereegranskat)abstract
- The gravitationally lensed supernova Refsdal appeared in multiple images produced through gravitational lensing by a massive foreground galaxy cluster. After the supernova appeared in 2014, lens models of the galaxy cluster predicted that an additional image of the supernova would appear in 2015, which was subsequently observed. We use the time delays between the images to perform a blinded measurement of the expansion rate of the Universe, quantified by the Hubble constant (H0). Using eight cluster lens models, we infer kilometers per second per megaparsec. Using the two models most consistent with the observations, we find kilometers per second per megaparsec. The observations are best reproduced by models that assign dark-matter halos to individual galaxies and the overall cluster.
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