| 1. |
- Björck, Niclas, et al.
(författare)
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Keramik : I: UV GAL Rapport 200:14. Snåret.Aspekter på sten-, brons och järnålder i Vendel, Väg E4, sträckan Uppsala-Mehedeby, Uppland, Vendels socken, Fallsboda 1:2, Karby 29:5, RAÄ 291
- 2007
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Rapport (populärvet., debatt m.m.)abstract
- Arkeologisk undersökning av boplats med lämningar från neolitikum, yngre bronsålder och vendeltid. På platsen fanns även sannolika gravar. Analyser görs av hus, keramik, pollen mm. Platsen har under vendeltid utnyttjats för tjärframställning
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| 2. |
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| 3. |
- Bergqvist, David, et al.
(författare)
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Invasive treatment for renovascular disease. A twenty year experience from a population based registry
- 2008
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Ingår i: Journal of Cardiovascular Surgery. - 0021-9509 .- 1827-191X. ; 49:5, s. 559-563
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To analyze time trends in invasive treatment of renovascular disease in one country. METHODS: Data have been analyzed from registrations in the Swedish Vascular Registry. RESULTS: Invasive treatment for renovascular disease contributes around 1% of all vascular surgery within the Swedish Vascular Registry. Over the twenty-year period 1987-2006 the population-based frequency of invasive treatment for renovascular disease has increased; 1 597 procedures have been registered with an increase over time. The age of the treated patients has increased over the period (P<0.001). There has been a shift from open to endovascular procedure and from isolated percutaneous transluminal renal angioplasty (PTRA) to PTRA combined with a stent. Complications and mortality are significantly higher in patients undergoing open reconstruction (P<0.01). One year follow-up is incomplete and long-term results are therefore not possible to evaluate through registry-data only. CONCLUSION: Using nation-wide registry data it is possible to analyze time-trends also concerning rare diseases or interventions. The changing pattern toward endovascular treatment of renovascular disease is obvious. Follow-up data at one year are incomplete.
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| 4. |
- Björck, Fredrik, et al.
(författare)
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Cyber Resilience – Fundamentals for a Definition
- 2015
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Ingår i: New Contributions in Information Systems and Technologies. - Cham : Springer. - 9783319164854 - 9783319164861 ; , s. 311-316
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Konferensbidrag (refereegranskat)abstract
- This short paper examines the concept of cyber resilience from an organizational perspective. Cyber resilience is defined as “the ability to continuously deliver the intended outcome despite adverse cyber events”, and this definition is systematically described and justified. The fundamental building blocks of cyber resilience are identified and analyzed through the contrasting of cyber resilience against cybersecurity with regards to five central characteristics.
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| 5. |
- Björck, Fredrik, 1972-
(författare)
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Discovering Information Security Management
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis is concerned with issues relating to the management of information security in organisations, motivated by the need for cost-efficient information security.It is based on the assumption that: in order to achieve cost-efficient information security, the point of departure must be knowledge about the empirical reality in which the management of information security takes place.The data gathering instruments employed are questionnaires with open-ended questions and unstructured research interviews. The empirical material is analysed, and conclusions are drawn following the principles of Grounded Theory. Data sources are professionals in the area of information security management, including information security consultants (n=13), certification auditors (n=8), and information security managers (n=8).The main contributions are: an integrated model illustrating the experts’ perceptions concerning the objectives, actors, resources, threats, and countermeasures of information security management; a framework for the evaluation, formation, and implementation of information security management systems; a new approach for the evaluation of information security in organisations; a set of success factors concerning the formation of information security management systems; and a problem inventory concerning the value and assessment of information security education and training.
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| 6. |
- Björck, Fredrik
(författare)
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Institutional theory : A new perspective for research into IS/IT security in organisations
- 2004
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Konferensbidrag (refereegranskat)abstract
- The aim of this position paper is to argue for the suitability of an institutional perspective in IS/IT (Information Systems/Information Technology) security research. Institutional theory, including some of its central concepts, is presented, along with examples of how it has been used in information systems research. A discussion of how the theory could benefit managerial IS/IT research concludes the paper.
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| 7. |
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| 8. |
- Björck, Fredrik, et al.
(författare)
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Outcomes in a Warfarin-Treated Population With Atrial Fibrillation
- 2016
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Ingår i: JAMA cardiology. - : American Medical Association (AMA). - 2380-6583 .- 2380-6591. ; 1:2, s. 172-180
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Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE Vitamin K antagonist (eg, warfarin) use is nowadays challenged by the non-vitamin K antagonist oral anticoagulants (NOACs) for stroke prevention in atrial fibrillation (AF). NOAC studies were based on comparisons with warfarin arms with times in therapeutic range (TTRs) of 55.2% to 64.9%, making the results less credible in health care systems with higher TTRs. OBJECTIVES To evaluate the efficacy and safety of well-managed warfarin therapy in patients with nonvalvular AF, the risk of complications, especially intracranial bleeding, in patients with concomitant use of aspirin, and the impact of international normalized ratio (INR) control. DESIGN, SETTING, AND PARTICIPANTS A retrospective, multicenter cohort study based on Swedish registries, especially AuriculA, a quality register for AF and oral anticoagulation, was conducted. The register contains nationwide data, including that from specialized anticoagulation clinics and primary health care centers. A total of 40 449 patients starting warfarin therapy owing to nonvalvular AF during the study period were monitored until treatment cessation, death, or the end of the study. The study was conducted from January 1, 2006, to December 31, 2011, and data were analyzed between February 1 and November 15, 2015. Associating complications with risk factors and individual INR control, we evaluated the efficacy and safety of warfarin treatment in patients with concomitant aspirin therapy and those with no additional antiplatelet medications. EXPOSURES Use of warfarin with and without concomitant therapy with aspirin. MAIN OUTCOMES AND MEASURES Annual incidence of complications in association with individual TTR (iTTR), INR variability, and aspirin use and identification of factors indicating the probability of intracranial bleeding. RESULTS Of the 40 449 patients included in the study, 16 201 (40.0%) were women; mean (SD) age of the cohort was 72.5 (10.1) years, and the mean CHA(2)DS(2)-VASc (cardiac failure or dysfunction, hypertension, age >= 75 years [doubled], diabetes mellitus, stroke [doubled]-vascular disease, age 65-74 years, and sex category [female]) score was 3.3 at baseline. The annual incidence, reported as percentage (95% CI) of all-cause mortality was 2.19% (2.07-2.31) and, for intracranial bleeding, 0.44%(0.39-0.49). Patients receiving concomitant aspirin had annual rates of any major bleeding of 3.07%(2.70-3.44) and thromboembolism of 4.90% (4.43-5.37), and those with renal failure were at higher risk of intracranial bleeding (hazard ratio, 2.25; 95% CI, 1.32-3.82). Annual rates of any major bleeding and any thromboembolism in iTTR less than 70% were 3.81% (3.51-4.11) and 4.41% (4.09-4.73), respectively, and, in high INR variability, were 3.04%(2.85-3.24) and 3.48% (3.27-3.69), respectively. For patients with iTTR 70% or greater, the level of INR variability did not alter event rates. CONCLUSIONS AND RELEVANCE Well-managed warfarin therapy is associated with a low risk of complications and is still a valid alternative for prophylaxis of AF-associated stroke. Therapy should be closely monitored for patients with renal failure, concomitant aspirin use, and poor INR control.
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| 9. |
- Björck, Fredrik, 1974-, et al.
(författare)
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Predictors for INR-control in a well-managed warfarin treatment setting
- 2019
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Ingår i: Journal of Thrombosis and Thrombolysis. - : Springer. - 0929-5305 .- 1573-742X. ; 47:2, s. 227-232
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Tidskriftsartikel (refereegranskat)abstract
- Warfarin is well studied in patients with non-valvular atrial fibrillation (AF). It has low complication rates for patients achieving individual Time in Therapeutic Range (iTTR)>70%. The risk scores SAMe-TT2R2 and PROSPER are designed to predict future TTR, but are derived from a heterogeneous population with generally low iTTR. The aim of this study was to evaluate predictors for high and low iTTR in an AF population in Sweden, where there is a generally good anticoagulation control. A retrospective register study based on Swedish warfarin dosing system AuriculA, including 28,011 AF patients starting treatment during 1 January 2006 to 31 December 2011. Complications and risk factors were analysed and related to iTTR. Mean age was 73.7 (SD +/- 9.5) years, with 42.0% women. Mean CHA(2)DS(2)-VASc score (SD) was 3.6 (+/- 1.7). For patients with iTTR<60% there were over three times higher prevalence of excessive alcohol consumption than for patients with iTTR>70% (3.7% vs. 1.1%). Previous stroke were more prevalent for patients with high than low iTTR (17.1% vs. 20.3%). Concomitant comorbidities were associated with increased risk of poor iTTR. In Swedish AF patients, excessive alcohol use is clearly associated with iTTR below 60%. Patients with previous stroke are more likely to get iTTR above 70%, unlike those with concomitant disorders who more often have poor anticoagulation control. The SAMe-TT2R2-score cannot be applied in Sweden.
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| 10. |
- Björck, Fredrik, et al.
(författare)
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Warfarin persistence among atrial fibrillation patients – why is treatment ended?
- 2016
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Ingår i: Cardiovascular Therapeutics. - : Wiley. - 1755-5914. ; 34:6, s. 468-474
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Tidskriftsartikel (refereegranskat)abstract
- Background and AimWarfarin treatment discontinuation is significant among patients with atrial fibrillation (AF). Studies mainly focused on whether the proportion of warfarin persistence and discontinuationare clinically appropriate are absent. This study evaluates warfarin persistence with focus on predictors for, and reasons to, warfarin discontinuation in AF patients.MethodsFrom the national quality register AuriculA, all AF patients in Sundsvall, Sweden, on warfarin treatment on January first, 2010 were included. These 478 patients were followed until discontinuation or study-stop December 31, 2013. By going through each patient’s medical record risk factors for thromboembolism, bleeding and causes of discontinuation were obtained.ResultsProportion of warfarin persistence was 0.91 (95% confidence interval (CI) 0.89 to 0.93) after one year and 0.73 (95% CI 0.69 to 0.77) after four years. Previous intracranial bleeding, excessive alcohol use, anemia and pulmonary or peripheral emboli were each associated with over two times higher risk of discontinuation (hazard ratio (HR) 5.66, CI 2.23-14.36, HR 2.54, CI 1.48-4.37, HR 2.40, CI 1.38-4.17, and HR 2.13, CI 1.02-4.46). Among patients discontinuing, 50.5% were due to questionable causes, such as sinus rhythm (33.9%), patients demand (10.1%) and falls (8.2%). The majority (43.1%) of treatment discontinuers were changed to aspirin, while 40.4% of them were left without medical stroke prophylaxis.ConclusionsAlthough persistence to warfarin among AF patients proves higher than previously reported, there is room for improvement since half of the discontinuers have questionable reasons for treatment stop and the majority of them receive no other efficient stroke prophylaxis.
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