| 1. |
- Moberg, Christina, et al.
(författare)
-
De unga gör helt rätt när de stämmer staten
- 2022
-
Ingår i: Aftonbladet. - 1103-9000.
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
|
|
| 2. |
- Agardh, Daniel, et al.
(författare)
-
Coeliac disease-specific tissue transglutaminase autoantibodies are associated with osteoporosis and related fractures in middle-aged women
- 2009
-
Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 1502-7708 .- 0036-5521. ; 44:5, s. 571-578
-
Tidskriftsartikel (refereegranskat)abstract
- Objective. To investigate whether the serological marker for coeliac disease, tissue transglutaminase autoantibody (tTGAb), is associated with decreased bone mass density (BMD) and increased frequency of fractures in middle-aged women screened for osteoporosis. Material and methods. The study comprised 6480 women (mean age 56 years, range 50-64) who answered a number of questionnaires and who underwent dual X-ray absorptiometry of the wrist bone. Serum samples were analysed for tTGAb using radioligand binding assays. A tTGAb level of 4 U/ml was used to determine a positive value and a level of 17 U/ml was used as an alternative discrimination of high levels. Results. A tTGAb level 4 U/ml was found among 90/6480 (1.4%) women and correlated with lower BMD (multiple linear regression coefficient -382.1; 95% CI = - 673.6-90.7, p=0.011) and with fracture frequency (r=0.18, p=0.023). The 59 women with tTGAb levels 17 U/ml had a lower BMD (0.410.08 g/cm2 versus 0.440.08 g/cm2, p=0.001) and a lower T-score (-1.401.28 versus -0.901.40, p=0.003) as well as a higher prevalence of osteoporosis (13.4% versus 6.5%, p=0.008) compared with the remaining 6421 women with tTGAb levels 17 U/ml. Furthermore, fracture frequency was more pronounced in women with tTGAb levels 17 U/ml, among whom 19/59 (32.2%) had fractures during the study period compared with 1204/6421 (18.8%) among women with tTGAb levels 17 U/ml (p=0.009). Conclusions. High levels of tTGAb indicating coeliac disease are associated with lower BMD and higher fracture frequency in women between 50 and 64 years of age. Osteometry is therefore warranted in middle-aged women detected with tTGAb.
|
|
| 3. |
- Ahmed, Sara
(författare)
-
Vithetens fenomenologi
- 2011
-
Ingår i: Vithetens hegemoni. - 9789186273194 ; , s. 125-151
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 4. |
|
|
| 5. |
- Björck, Sara, et al.
(författare)
-
Reduced Bone Mineral Density in Children with Screening-detected Celiac Disease
- 2017
-
Ingår i: Journal of Pediatric Gastroenterology and Nutrition. - 0277-2116. ; 65:5, s. 526-532
-
Tidskriftsartikel (refereegranskat)abstract
- Objectives: The aim of the study was to assess whether bone mass and metabolism are impaired in genetically at-risk children with screening-detected celiac disease. Methods: Included were 71 children with screening-detected celiac disease diagnosed at 10.0 ± 0.7 (mean ± standard deviation) years and 142 matched controls and 30 children with screening-detected celiac disease diagnosed at 3.3 ± 0.4 years of age presently on a gluten-free diet for 6.9 ± 1.1 years and 60 matched controls. All participants were assessed for bone mineral density (BMD) of total body and spine by dual X-ray absorptiometry, serum 25(OH) vitamin D3, parathyroid hormone (PTH), interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-13, IL-15, interferon gamma, and tumor necrosis factor alpha. Results: At diagnosis, screening-detected celiac disease children as compared to controls had a mean-0.03 g/cm 2 reduced BMD of both total body and spine (P = 0.009 and P = 0.005, respectively), a mean-11.4 nmol/L lower level of 25(OH) vitamin D3 (P < 0.001), and a mean +1.0 pmol/L higher PTH level (P < 0.001). Systemic levels of the cytokines IL-1β, IL-6, IL-8, IL-10, IL-12p70, IL-13, and tumor necrosis factor alpha were all increased in screening-detected celiac disease as compared to controls (P < 0.001). No difference in BMD, 25(OH) vitamin D3, PTH, and cytokine levels were detected in children on a gluten-free diet compared with controls. Conclusions: Children with screening-detected celiac disease have reduced BMD, lower levels of vitamin D3, higher levels of PTH, and signs of systemic inflammation compared with controls. These differences were not found in celiac disease children on a gluten-free diet, indicating that children with screening-detected celiac disease benefit from an early diagnosis and treatment.
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
- Björck, Sara, et al.
(författare)
-
Screening Detects a High Proportion of Celiac Disease in Young HLA-genotyped Children.
- 2010
-
Ingår i: Journal of Pediatric Gastroenterology and Nutrition - Jpgn. - 1536-4801. ; 50, s. 49-53
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND AIMS:: Celiac disease is associated with tissue transglutaminase autoantibodies (tTGAb) and the human leukocyte antigen (HLA)-risk alleles DQB1*02 and DQB1*0302. The aim was to estimate the proportion of undiagnosed celiac disease in children with HLA risk at 3 years of age. PATIENTS AND METHODS:: From a population-based HLA-DQ screening study of newborns born between June 2001 and August 2004 in the southern part of Sweden, 6206 children with HLA-risk alleles were identified and asked to participate at a mean 3.3 +/- 0.4 years of age. As controls, 7654 children with HLA-nonrisk alleles were asked to participate. In all, 1620 (26.1%) children with HLA risk and 1815 (23.7%) controls were screened for tTGAb using radioligand-binding assays. Celiac disease was established by intestinal biopsy in children with a confirmed positive tTGAb test. RESULTS:: Twenty-three children reported already having clinically diagnosed celiac disease and did not participate further. In children with HLA-risk genotypes, 73 of 1620 (4.5%, 95% CI 3.5%-5.5%) were tTGAb-positive compared with none of 1815 from the controls (P < 0.0001). Seventy-one children underwent biopsy (1 refused biopsy and 1 biopsy failed), of whom 56 of 1618 (3.5%, 95% CI 2.6%-4.4%) had damaged intestinal mucosa classified as celiac disease. The ratio between clinically and screening detected celiac disease in this study was 1:2.4 (23:56). CONCLUSIONS:: The proportion of clinically undetected celiac disease may be particularly high among 3-year-old children with HLA-DQB1*02 and DQB1*0302 in Sweden, where these 2 HLA-risk alleles frequently occur.
|
|
| 9. |
- Björck, Sara
(författare)
-
Searching for Celiac Disease Screening-detected celiac disease in an HLA-genotyped birth cohort
- 2015
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Objectives: Celiac disease is a common immune mediated enteropathy strongly associated with HLA-DQB1*02 (DQ2), *0302 (DQ8), or both and the presence of tissue transglutaminase autoantibodies (tTGA). Prevalence studies have revealed that most affected individuals go undetected because of subclinical signs or being asymptomatic rendering screening a method for identification. However, less is known about subclinical manifestations of screening-detected celiac disease during childhood and if these motivate identification and treatment. The overall aim of the present research was to identify children with screening-detected celiac disease in an HLA-genotyped birth cohort and to study systemic cytokines and bone mineral density (BMD) in these children. Methods: Children were HLA-genotyped at birth and offered screening at three and nine years of age by detection of tTGA in plasma using radioligand binding assays. Children repeatedly positive for tTGA underwent intestinal biopsy to confirm diagnosis of celiac disease. The cytokines IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, and TNF-α were analysed at time of diagnosis and after treatment with a gluten-free diet and compared with matched controls. At nine years of age, children with screening-detected celiac disease were examined by dual X-ray absorptiometry for analysis of BMD and for serum 25(OH) vitamin D3 and plasma parathyroid hormone (PTH) and compared to matched controls. Results: Screening-detected celiac disease was found in 3.5% (56/1618) of three year old children having HLA-risk alleles compared with none (0/1815) among children not having these risk alleles (p<0.001). A follow-up screening at nine years of age identified an additional 3.8% (72/1907) with celiac disease in the HLA-risk group compared with none (0/2167) in the control group (p<0.001). Three-year old children with screening-detected celiac disease had systemically elevated pro-inflammatory cytokines of both TH1 and TH2 pattern compared to controls of which most were down-regulated after starting a gluten-free diet. At nine years of age, children with screening-detected celiac disease had lower BMD, lower levels of vitamin D but higher PTH levels compared with matched controls. In contrast, children on a gluten-free diet did not differ from their matched controls. Conclusions: Screening-detected celiac disease is only found among children at genetic risk but repeated testing during childhood is necessary to detect new patients. HLA-genotyping could therefore be used to select large populations to be screened for celiac disease. Children with screening-detected celiac disease have systemically elevated pro-inflammatory cytokines and low BMD but normal values on a gluten-free diet, indicating that children with screening-detected celiac disease could benefit from early identification and treatment.
|
|
| 10. |
- Björck, Sara, et al.
(författare)
-
Serum cytokine pattern in young children with screening detected celiac disease.
- 2015
-
Ingår i: Clinical and Experimental Immunology. - : Oxford University Press (OUP). - 0009-9104 .- 1365-2249. ; 179:2, s. 230-235
-
Tidskriftsartikel (refereegranskat)abstract
- Celiac disease is an autoimmune disease characterized by inflammation localized to the small bowel, but less is known about systemic signs of inflammation. The aim was to measure cytokines of the T helper 1 (Th1) and T helper 2 (Th2) cell patterns in children with screening detected celiac disease before and after treatment with a gluten free diet.
|
|
