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- Franceschini, N., et al.
(författare)
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GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
- 2018
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans. © 2018, The Author(s).
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| 2. |
- Hammersberg, Peter, 1961, et al.
(författare)
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Modelling the Variation of Tensile Properties of High-Silicon Ductile Iron
- 2018
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Ingår i: 2018 AFS Transactions, American Foundry Society. - 9780874334630 ; 126, s. 155-164
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Konferensbidrag (refereegranskat)abstract
- For an optimized gating system, the influence of chemical composition can be controlled to a greater extent than in non-optimized conditions, where hidden mechanisms prevail. In this work, GJS-600-10 (EN 1563:2012) solid-solution-strengthened ferritic spheroidal graphite iron with advantageous machinability due to uniform hardness, has been used to elucidate interaction effects and create a material regression model to predict the tensile properties. In this case, key predictors are related to the tensile properties (Rp0,2, Rm, A), of over 120 industrial tensile specimens from 10 years of research. A partial least square (PLS) regression reveals that elements in the steel scrap strongly affect elongation, yield strength and ultimate tensile strength. The analysis reveals that strength to a great extent can be predicted by the chemical composition whereas ductility also depends on other factors.
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| 3. |
- Hammersberg, Peter, 1961, et al.
(författare)
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Variation of tensile properties of high silicon ductile iron
- 2018
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Ingår i: Mater. Sci. Forum. - 9783035710557 ; 925 MSF, s. 280-287
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Konferensbidrag (refereegranskat)abstract
- The casting processes are characterized by complex relationships between predictors and responses. It is the fundamental understanding of these complex relationships that often involves hundreds of factors, which improves quality without losing productivity and raising cost. In this work, cast solid solution strengthened ferritic spheroidal graphite irons GJS-500-14 and GJS-600-10 (EN 1563:2012) have been evaluated. These materials offer stronger components with good machinability owing to their even hardness properties. In this case the predictors are chemical composition, gating layout, foundry set-up, testing procedure and equipment etc. and the responses are the tensile properties (Rp0.2, Rm, A5). Here 200 tensile specimens compiled from industrial foundry melts from over 30 years of research have created a state-of-the-art platform for statistical engineering in order to perform Exploratory Data Analysis (EDA) and data visualization. This statistical platform has provided new insight on how foundries should treat complex relationships between predictors and responses in order to identify sources of variation and interaction effects.
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| 6. |
- Nilsson, Karl-Fredrik, et al.
(författare)
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A probabilistic methodology to determine failure probabilities and acceptance criteria for the KBS-3 inserts under ice-age load conditions
- 2008
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Ingår i: Nuclear Technology. - 0029-5450 .- 1943-7471. ; 163:1, s. 3-14
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Tidskriftsartikel (refereegranskat)abstract
- The Swedish KBS-3 copper-cast iron canister for geological disposal of spent nuclear fuel is in an advanced stage. This paper deals with the cast iron insert that provides the mechanical strength of the canister and outlines an approach to assess the failure probabilities for manufactured canisters at large isostatic pressure (44 MPa) that could occur during future glaciations and first steps to derive acceptance criteria to ensure that failure probabilities are extremely small. The work includes a statistical test program using three inserts to determine the tensile, compression, and fracture properties. Specimens used for material characterization were also investigated by microstructural analysis to determine the microstructure and to classify and size defects. It was found that the material scatter and low ductility were caused by many defect types, but slag defects in the form of oxidation films were the most important ones. These data were then used to compute defect distributions for the probabilistic failure analysis of the KBS-3 canisters. A large number of finite element-analyses of canisters were performed at the maximum design load (44 MPa) covering distributions of material parameters and geometrical features of the canisters. The computed probabilities for fracture and plastic collapse were very low even for material data with low ductility. Two large-scale isostatic compression tests of KBS-3 mock-ups to verify safety margins are also described. The failure occurred at loads above 130 MPa in both cases, indicating a safety margin of at least a factor 3 against the maximum design load. As a result of the project, new acceptance criteria are being proposed for insert geometry and material properties, and the manufacturing process for inserts has been modified to ensure that these criteria are always fulfilled.
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