| 1. |
- Åkerström, Tobias, et al.
(författare)
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Comprehensive Re-Sequencing of Adrenal Aldosterone Producing Lesions Reveal Three Somatic Mutations near the KCNJ5 Potassium Channel Selectivity Filter.
- 2012
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Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 7:7
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Tidskriftsartikel (refereegranskat)abstract
- Aldosterone producing lesions are a common cause of hypertension, but genetic alterations for tumorigenesis have been unclear. Recently, either of two recurrent somatic missense mutations (G151R or L168R) was found in the potassium channel KCNJ5 gene in aldosterone producing adenomas. These mutations alter the channel selectivity filter and result in Na(+) conductance and cell depolarization, stimulating aldosterone production and cell proliferation. Because a similar mutation occurs in a Mendelian form of primary aldosteronism, these mutations appear to be sufficient for cell proliferation and aldosterone production. The prevalence and spectrum of KCNJ5 mutations in different entities of adrenocortical lesions remain to be defined.
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| 2. |
- Berglund, Martin, 1981-, et al.
(författare)
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Parsing unranked tree languages, folded once
- 2023
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Ingår i: Fundamentals of computation theory. - : Springer Nature. - 9783031435867 ; , s. 60-73
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Konferensbidrag (refereegranskat)abstract
- A regular unranked tree folding consists of a regular unranked tree language and a folding operation that merges, i.e., folds, selected nodes of a tree to form a graph; the combination is a formal device for representing graph languages. If, in the process of folding, the order among edges is discarded so that the result is an unordered graph, then two applications of a fold operation is enough to make the associated parsing problem NP-complete. However, if the order is kept, then the problem is solvable in non-uniform polynomial time. In this paper we address the remaining case where only one fold operation is applied, but the order among edges is discarded. We show that under these conditions, the problem is solvable in non-uniform polynomial time.
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| 3. |
- Berglund, Martin, 1981-, et al.
(författare)
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Shuffled languages : representation and recognition
- 2013
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Ingår i: Theoretical Computer Science. - : Elsevier. - 0304-3975 .- 1879-2294. ; 489-490, s. 1-20
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Tidskriftsartikel (refereegranskat)abstract
- Language models that use interleaving, or shuffle, operators have applications in various areas of computer science, including system verification, plan recognition, and natural language processing. We study the complexity of the membership problem for such models, in other words, how difficult it is to determine if a string belongs to a language or not. In particular, we investigate how interleaving can be introduced into models that capture the context-free languages.
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| 4. |
- Berglund, Martin, 1981-, et al.
(författare)
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Transduction from trees to graphs through folding
- 2023
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Ingår i: Information and Computation. - : Elsevier. - 0890-5401 .- 1090-2651. ; 295
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Tidskriftsartikel (refereegranskat)abstract
- We introduce a fold operation that realises a tree-to-graph transduction by merging selected nodes in the input tree to form a possibly cyclic output graph. The work is motivated by the increasing use of graph-based representations in semantic parsing. We show that a suitable class of graphs languages can be generated by applying the fold operation to regular unranked tree languages. We investigate two versions of the fold operation, one that preserves a depth-first ordering between the edges, and one that does not. Finally, we demonstrate that the time complexity for the associated non-uniform membership problem is solvable in polynomial time for the order-preserving version, and NP-complete for the order-cancelling one.
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| 5. |
- Björklund, Jesper, et al.
(författare)
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Disentangling the multi-faceted growth patterns of primary Picea abies forests in the Carpathian arc
- 2019
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Ingår i: Agricultural and Forest Meteorology. - : Elsevier BV. - 0168-1923. ; 271, s. 214-224
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Tidskriftsartikel (refereegranskat)abstract
- © 2019 Elsevier B.V. A tree's radial growth sequence can be thought of as an aggregate of different growth components such as age and size limitations, presence or absence of disturbance events, continuous impact of climate variability and variance induced by unknown origin. The potentially very complex growth patterns with prominent temporal and spatial variability imply that our understanding of climate-vegetation feedbacks essentially benefits from the expansion of large tree ring networks into data-poor regions, and our ability to disentangle growth constraints by comparing ring series at multiple scales. In this study, we analyze Central-Eastern Europe's most substantial assemblage of primary Norway spruce forests found in the Carpathian arc. The vast data set, >10,000 tree-ring series, is stratified along a prominent gradient in climate response space over four separate landscapes. We integrated curve intervention detection and dendroclimatic standardization to decompose tree growth variance into climatic, disturbance and residual components to explore the behavior of the components over increasingly larger spatial hierarchies. We show that the residual variance of unknown origin is the most prominent variance in individual Carpathian spruce trees, but at larger spatial hierarchies, climate variance dominates. The variance induced by climate was further explored with common correlation analyses, growth response to extreme climate years and forward modeling of tree growth to identify leading modes of climate response, and potentially non-linear and mixed climate response patterns. We find that the climatic response of the different forest landscapes overall can be described as an asymptotic response to June and July temperatures, most likely intermixed with influence from winter precipitation. In the collection of landscapes, Southern Romania stands out as being the least temperature sensitive and most likely exhibiting the most complicated mixed temperature and moisture limitation.
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| 6. |
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| 7. |
- Diarbakerli, E., et al.
(författare)
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Learning from the past to plan for the future: A scoping review of musculoskeletal clinical research in Sweden 2010-2020
- 2022
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Ingår i: Upsala Journal of Medical Sciences. - : Uppsala Medical Society. - 0300-9734 .- 2000-1967. ; 127:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: The aims of this study are to 1) determine the scope of musculoskeletal (MSK)-related clinical research in Sweden; 2) collate the amount of first-tier funding received; 3) discuss strategies and infrastructure supporting future MSK clinical trials in Sweden. Methods: A systematic scoping review protocol was applied in PubMed, Scopus, and SweCRIS databases. The articles were examined, and data were extracted in multiple stages by three blinded authors. Results: The search strategy resulted in 3,025 publications from 479 Swedish-affiliated authors. Primary health care was the basis for 14% of the publications, 84% from secondary health care, and 2% from occupational health care with a similar proportional distribution of first-tier research grant financing. Approximately one in six publications were randomized controlled trials (RCTs), while the majority were of observational cohort design. The majority of publications in primary and occupational health care were related to pain disorders (51 and 67%, respectively), especially diagnosis, prognosis, and healthcare organizational-related interventions (34%) and rehabilitation (15%) with similar proportional distribution of first-tier research grant financing. In secondary health care, rheumatic inflammatory disorder-related publications were most prevalent (30%), most frequently concerning diagnosis, prognosis, and healthcare organizational-related interventions (20%), attracting approximately half of all first-tier funding. Publications related to degenerative joint disorders (25%), fractures (16%), and joint, tendon, and muscle injuries (13%) frequently concerned surgical and other orthopedic-related interventions (16, 6, and 8%, respectively). Pain disorder-related publications (10%) as well as bone health and osteoporosis-related publications (4%) most frequently concerned diagnosis, prognosis, and healthcare organizational-related interventions (5 and 3%, respectively). Conclusions: Swedish-affiliated MSK disorder research 2010-2020 was predominantly observational cohort rather than RCT based. There was skewed first-tier funding allocation considering prevalence/incidence and burden of disease. Use of infrastructure supporting register-based RCTs, placebo-controlled RCTs, and hybrid effectiveness-implementation studies on prevention and clinical intervention is important strategies for the future in all healthcare sectors.
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| 8. |
- Diarbakerli, Elias, et al.
(författare)
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Swedish musculoskeletal researchers view on a collaborative network and future research priorities in Swedish healthcare
- 2024
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Ingår i: Musculoskeletal Care. - : John Wiley & Sons. - 1478-2189 .- 1557-0681. ; 22:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Musculoskeletal disorders (MSK) are a global burden causing significant suffering and economic impact. Systematic identification and targeting of research questions of highest interest for stakeholders can aid in improving MSK disorder knowledge and management.Objective: To obtain Swedish MSK researchers' opinions and views on a collaborative Swedish MSK network (SweMSK) and identify future research areas of importance for Swedish MSK research.Methods: A web-based survey was conducted July to September 2021 to collect data from 354 Swedish MSK researchers. The survey focused on the need, objectives, and structure of a SweMSK network and identified prioritised areas for future MSK research.Results: The study included 141 respondents, of which 82 were associate professors or professors. The majority (68%) supported the creation of a new musculoskeletal network. The most supported element was increased collaboration regarding nationwide and multicenter studies. Respondents recommended the creation of a homepage and the establishment of national work groups with different specific interests as the primary elements of a new network.Conclusion: The results demonstrated a need and desire for increased national research collaboration and the creation of a new musculoskeletal network. The high academic experience and active research participation of the respondents suggest the need for MSK disorder knowledge and management improvement in Sweden. Therefore, the SweMSK network may help facilitate effective collaboration and research efforts that can contribute to the advancement of MSK disorder management and care. This study may provide valuable insights for policymakers, clinicians, and researchers to improve MSK disorder care and management in Sweden.
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| 9. |
- Hadrévi, Jenny, et al.
(författare)
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Systemic differences in serum metabolome : a cross sectional comparison of women with localised and widespread pain and controls
- 2015
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Chronic musculoskeletal pain exists either as localised to a single region or as widespread to multiple sites in several quadrants of the body. Prospective studies indicate that widespread pain could act as a far end of a continuum of musculoskeletal pain that started with chronic localised pain. The mechanism by which the transition from localised pain to widespread occurs is not clear, although many studies suggest it to be an altered metabolism. In this study, systemic metabolic differences between women with chronic localised neck-shoulder pain (NP), women with chronic widespread pain (CWP) and women who were healthy (CON) were assessed. Blood samples were analysed taking a metabolomics approach using gas chromatography mass spectrometry (GC-MS) and orthogonal partial least square discriminant analysis (OPLS-DA). The metabolomics analysis showed a clear systematic difference in the metabolic profiles between the subjects with NP and the CON but only a weak systematic difference between the subjects with CWP and the CON. This most likely reflects a difference in the portion of the metabolome influenced by the two pain conditions. In the NP group, the overall metabolic profile suggests that processes related to energy utilisation and lipid metabolism could be central aspects of mechanisms maintaining disorder.
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| 10. |
- Nygren, Jens Martin, 1976-, et al.
(författare)
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Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion
- 2008
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Ingår i: Nature Cell Biology. - London : Nature Publishing Group. - 1465-7392 .- 1476-4679. ; 10:5, s. 584-92
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Tidskriftsartikel (refereegranskat)abstract
- Recent studies have suggested that regeneration of non-haematopoietic cell lineages can occur through heterotypic cell fusion with haematopoietic cells of the myeloid lineage. Here we show that lymphocytes also form heterotypic-fusion hybrids with cardiomyocytes, skeletal muscle, hepatocytes and Purkinje neurons. However, through lineage fate-mapping we demonstrate that such in vivo fusion of lymphoid and myeloid blood cells does not occur to an appreciable extent in steady-state adult tissues or during normal development. Rather, fusion of blood cells with different non-haematopoietic cell types is induced by organ-specific injuries or whole-body irradiation, which has been used in previous studies to condition recipients of bone marrow transplants. Our findings demonstrate that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation.
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