| 1. |
- Aaltonen, Kirsimari, et al.
(författare)
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Cyclin D1 expression is associated with poor prognostic features in estrogen receptor positive breast cancer
- 2009
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Ingår i: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 1573-7217 .- 0167-6806. ; 113:1, s. 75-82
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Tidskriftsartikel (refereegranskat)abstract
- Cyclins D1 and E play an important role in breast carcinogenesis. High cyclin E expression is common in hormone receptor negative and high grade aggressive breast cancer, whereas cyclin D1 in hormone receptor positive and low grade breast cancer. Experimental data has suggested that cyclin D1 and E mediate cell proliferation by different mechanisms in estrogen receptor (ER) positive and negative breast cancer. To test this hypotheses in large breast cancer material and to clarify the histopathological correlations of cyclin E and D1, especially the association with proliferation, we analyzed cyclin E and D1 immunohistochemical expression on breast tumour microarrays consisting of 1348 invasive breast cancers. High cyclin D1 expression was associated with high grade (P < 0.0005), high cyclin A (P < 0.0005) and Ki67 (P < 0.0005) expression among ER positive but with low grade (P = 0.05) and low Ki67 (P = 0.01) expression among ER negative breast cancers. Cyclin E and D1 expression correlated positively in ER positive (P < 0.0005) but had a negative correlation in ER negative tumours (P = 0.004). Cyclin E associated with high grade among all tumours (P < 0.0005). In conclusion, the findings of this study show that cyclin D1 has separate roles, and proliferation is driven by different mechanisms in ER positive and negative breast cancers.
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| 2. |
- Ahlin, Cecilia, 1966-
(författare)
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Cyclin A and cyclin E as prognostic factors in early breast cancer
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Breast cancer is one of the most common malignancies in women. Due to early detection and the use of screening programs approximately 60% of all new cases lack lymph node involvement. Today, a substantial proportion of these women will be offered adjuvant systemic chemotherapy. However, better proliferation markers are needed to predict patient outcome and to avoid overtreatment. Cyclin A, cyclin E and Ki-67 are all markers for proliferation and involved in the regulation of the cell cycle. Overexpression has been associated with disease recurrence in several studies, but the results have not been consistent. However, none of these studies has investigated aberrant expression of cyclin E (the expression of cyclin E during phases of the cell cycle other than late G1 and early S-phase). Studies have shown that aberrant cyclin E might provide additional prognostic information compared to cyclin E alone.The aims of this thesis were 1.to investigate the prognostic value of cyclin A, cyclin E and aberrant cyclin E in early breast cancer. 2.to validate the tissue microarray (TMA) technique for cyclin A and 3.to define the most optimal cut-off values for cyclin A and Ki-67.We found that the agreement of TMA and large section results was good with kappa values 0.62-0.75 and that the reproducibility of the two readers’ results was good or even very good, with kappa values 0.71 – 0.87. The optimal cut-off value for cyclin A average was 8% and for cyclin A maximum value 11%. The corresponding values for Ki-67 were 15 and 22%. Neither cyclin E nor aberrant cyclin E was a prognostic factor in low-risk node negative breast cancer patients. Finally, we conclude that cyclin A is a prognostic factor in node negative breast cancer (univariate analysis average value OR=2.9 95% CI 1.8-4.6; maximum value OR=3.7 95% CI 2.3-5.9).
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| 3. |
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| 4. |
- Andersson, Greger, et al.
(författare)
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Akademiska kapellet grundas
- 1996
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Ingår i: Spelglädje i Lundagård. - 9179663435 ; , s. 23-28
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Antonson, Hans, et al.
(författare)
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Bedömning av skada på bevarandeintressen : ett kunskapsunderlag inför en metodutveckling
- 2002
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Bedömning av skada på bevarandeintressen är ofta en svag punkt i miljökonsekvensbeskrivningar (MKB). Generell metodutveckling i detta avseende behövs som stöd för utförare av analyser och beskrivningar för vägprojekt. Projektet Bedömning av skada på bevarandeintressen har haft som uppgift att utveckla en metod som kan bedöma skada på skyddade områden för natur, kultur eller friluftsliv. De studerade områdestyperna är riksintresseområden och Natura-2000-områden.Studien bygger på en större genomgång av bl.a. svensk, europeisk och överstatlig handboks- eller utbildningslitteratur, utredningsmaterial från infrastrukturprojekt samt gällande riktlinjer och lagar. Ur denna genomgång belystes bl.a. följande aspekter: de miljöaspekter vilka utpekas kan skadas, hur skada bedöms, hur påverkan, effekt och konsekvens beskrivs, vilka värderingsgrunder som används och bevarandevärdenas rättsliga grunder. Aspekterna ingick som byggstenar i en metodkonstruktion.
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| 6. |
- Antonson, Hans, et al.
(författare)
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Bedömning av skada på bevarandeintressen : en metodutveckling, huvudrapport
- 2002
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Assessment of damage to heritage assets is often a weak element inenvironmental impact assessments (EIA). General method development is neededin this respect as support for the authors of analyses and descriptions forroad projects. The task of the project Assessment of damage to heritageassets was to develop a method which can assess damage to protected areas fornature, culture or outdoor activities. The types of areas which have beenstudied are areas of national interest and Natura 2000 areas. The method hasbeen developed with reference to a major review of e.g. Swedish, European andsupranational handbook and educational literature, investigation materialfrom infrastructure projects, and current guidelines and laws. The method isdesigned as a checklist which deals with a number of planning stages, i.e. anumber of questions each of which must be answered before proceeding to theend of the checklist where an assessment - no damage, damage or pronounceddamage - has to be made. At the same time, those completing the checklistmust also answer a number of relevant questions in order to motivate theirstandpoint regarding the assessment of damage, both to themselves and toothers. The method has been tested on a newly produced EIA and has beenjudged by external reviewers to work well.
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| 7. |
- Antonson, Hans, et al.
(författare)
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Crash Barriers and Driver Behavior : A Simulator Study
- 2013
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Ingår i: Traffic Injury Prevention. - : Informa UK Limited. - 1538-9588 .- 1538-957X. ; 14:8, s. 874-880
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The study examines how drivers experience a conventional W-beam guardrail (metal crash barrier) along both sides of narrow versus wider roads (single carriageway with 2 lanes) in terms of stress, feelings, and driving patterns and whether subjective experience concurs with the actual driving patterns captured by the quantitative data.Methods: The study used different methods to capture data, including the VTI Driving Simulator III (speed and lateral vehicle position) in conjunction with electrocardiogram (ECG) data on heart rate variability (HRV) and questionnaires (oral during driving and written after driving). Eighteen participants-8 men and 10 women-were recruited for the simulator study and the simulator road section was 10 km long.Results: Driving speeds increased slightly on the wider road and on the road with a crash barrier, and the lateral driving position was nearer to the road center on the narrower road and on the road with a crash barrier. The HRV data did not indicate that participants experienced greater stress due to road width or due to the presence of a crash barrier. Participant experience captured in the oral questionnaires suggested that road width did not affect driver stress or driving patterns; however, the written questionnaire results supported the simulator data, indicating that a wider road led to increased speed. None of the participants felt that crash barriers made them feel calmer.Conclusions: We believe that there is a possibility that the increased speed on roads with crash barriers may be explained by drivers’ sense of increased security. This study demonstrates that an experimental design including experience-based data captured using both a simulator and questionnaires is productive. It also demonstrates that driving simulators can be used to study road features such as crash barriers. It seems more than likely that features such as street lamps, signs, and landscape objects could be tested in this way. © 2013 Copyright Taylor and Francis Group, LLC.
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| 8. |
- Antonson, Hans, et al.
(författare)
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Does the official strategy protect or destroy our cultural heritage? : corrosion of archaeological artefacts exposed to de-icing salt in Sweden
- 2006
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- When new roads are built today, the Swedish official strategy is to leave in situ the cultural layers that are not directly affected by the road construction, rather than to excavate the entire layer even if it stretches outside the verge of the planned road. This strategy has its roots in the Act concerning Ancient Monuments and Finds and is built on the assumption that the soil layers protect the archaeological artefacts far better than the national archives and museum shelves. The cultural layers are looked upon as a national archive in situ. However, recently excavated metal artefacts generally exhibit greater deterioration than those excavated many years ago, implying that recent pollution is responsible for accelerating the corrosion. Unfortunately, the de-icing salt used in winter maintenance operations does not stay on the road surface, where it has its desired effects on traffic safety and accessibility, but is transported - by different mechanisms - to the sides of the road where it may have undesired effects on e.g. vegetation, soil and groundwater, and possibly also on archaeological artefacts (metal, wood, cloth, bone, leather etc). The mechanisms responsible for the roadside exposure to salt are influenced by many factors such as wind, road surface condition, topography and surrounding vegetation. In many cases the salt will spread several tens of meters from the road, and in the worst cases raised levels of salt may be found up to some hundred meters from the road. When transported by groundwater, salt may be moved very far and may reach cultural layers in discharge areas where the ground water reaches the soil surface layers. This paper describes the problem of exposure to de-icing salt and the possible corrosion of archaeological artefacts with reference to a literature review and suggests some ways in which the extent of the suggested problem can be investigated by field studies under semi-controlled conditions and by a GIS survey.
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| 9. |
- Antonson, Hans, et al.
(författare)
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Effekter av vintervägsaltning på kulturmiljö. En pilotstudie av fornlämningskategorin milstolpe
- 2021
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- En semikvantitativ pilotstudie av 72 milstolpar (35 av kalksten och 37 av gjutjärn) i Södermanlands respektive Östergötlands län har genomförts med syftet att studera sambandet mellan vintervägsalt-ning och milstolparnas skador. Milstolparnas skador har klassats utifrån högupplösta fotografier, dess avstånd från vägen och framsidans väderstreck. Rapporten visar att vissa delar av milstolpen är mer skadade än andra och att en trolig orsak till detta för gjutjärnsstolparna är vintervägsalt. Sambandet är inte lika tydligt för kalkstensstolpar där studien uppmanar till fördjupade undersökningar. Den förenklade och relativt kostnadseffektiva semikvantitativa metodiken framtagen i denna pilotstudie har visat sig fungera och har potentialen att förfinas.
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| 10. |
- Antonson, Hans, et al.
(författare)
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Landscape heritage objects' effect on driving : a combined driving simulator and questionnaire study.
- 2014
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Ingår i: Accident Analysis and Prevention. - : Elsevier BV. - 0001-4575 .- 1879-2057. ; 62, s. 168-77
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Tidskriftsartikel (refereegranskat)abstract
- According to the literature, landscape (panoramas, heritage objects e.g. landmarks) affects people in various ways. Data are primarily developed by asking people (interviews, photo sessions, focus groups) about their preferences, but to a lesser degree by measuring how the body reacts to such objects. Personal experience while driving a car through a landscape is even more rare.In this paper we study how different types of objects in the landscape affect drivers during their drive. A high-fidelity moving-base driving simulator was used to measure choice of speed and lateral position in combination with stress (heart rate measure) and eye tracking. The data were supplemented with questionnaires. Eighteen test drivers (8 men and 10 women) with a mean age of 37 were recruited. The test drivers were exposed to different new and old types of landscape objects such as 19th century church, wind turbine, 17th century milestone and bus stop, placed at different distances from the road driven.The findings are in some respect contradictory, but it was concluded that that 33% of the test drivers felt stressed during the drive. All test drivers said that they had felt calm at times during the drive but the reason for this was only to a minor degree connected with old and modern objects. The open landscape was experienced as conducive to acceleration. No significant differences could be observed concerning the test drivers' gaze between old or modern objects, but a significant difference was observed between the test drivers' gaze between road stretches with faraway objects and stretches without objects.
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