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Sökning: WFRF:(Blomqvist Martha)

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  • Ahearn, Thomas U., et al. (författare)
  • Common variants in breast cancer risk loci predispose to distinct tumor subtypes
  • 2022
  • Ingår i: Breast Cancer Research. - : Springer Nature. - 1465-5411 .- 1465-542X. ; 24:1
  • Tidskriftsartikel (refereegranskat)abstract
    • BackgroundGenome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear.MethodsAmong 106,571 invasive breast cancer cases and 95,762 controls of European ancestry with data on 173 breast cancer variants identified in previous GWAS, we used novel two-stage polytomous logistic regression models to evaluate variants in relation to multiple tumor features (ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and grade) adjusting for each other, and to intrinsic-like subtypes.ResultsEighty-five of 173 variants were associated with at least one tumor feature (false discovery rate < 5%), most commonly ER and grade, followed by PR and HER2. Models for intrinsic-like subtypes found nearly all of these variants (83 of 85) associated at p < 0.05 with risk for at least one luminal-like subtype, and approximately half (41 of 85) of the variants were associated with risk of at least one non-luminal subtype, including 32 variants associated with triple-negative (TN) disease. Ten variants were associated with risk of all subtypes in different magnitude. Five variants were associated with risk of luminal A-like and TN subtypes in opposite directions.ConclusionThis report demonstrates a high level of complexity in the etiology heterogeneity of breast cancer susceptibility variants and can inform investigations of subtype-specific risk prediction.
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  • Bjarnegård, Elin, 1976- (författare)
  • Men in Politics : Revisiting Patterns of Gendered Parliamentary Representation in Thailand and Beyond
  • 2009
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Male parliamentary dominance, rather than the corresponding female parliamentary underrepresentation, is the object of study in this thesis. This shift in focus implies a gendered analysis centered on men and men’s practices. The thesis contributes to our understanding of how male dominance is maintained and reinvented by empirically studying male parliamentary dominance in clientelist settings. Worldwide trends of parliamentary representation are analyzed statistically and constitute the starting-point for a case study of male political networks in Thailand. Clientelism is a strategy used by political actors to increase predictability in politically unpredictable settings. The thesis shows that clientelism is an informal political practice that requires the building and maintenance of large and localized networks to help distribute services, goods and/or money in exchange for political support. Where political parties also use candidate selection procedures that are informal, exclusive and localized, there are ample openings for clientelist practices to translate into political power and ultimately parliamentary seats. This study also coins and develops a new concept: homosocial capital. It shows that clientelist networks are and continue to be male dominated because homosocial capital, a political capital accessible only to men, is needed for electoral success. Homosocial capital has two main components: a perceived pragmatic necessity to build linkages to those with access to important resources in society and a more psychological desire to cooperate with individuals whose behavior can be understood, predicted and trusted.
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  • Blomqvist, Martha, et al. (författare)
  • Action research with dual agendas
  • 2011
  • Ingår i: Equality, Growth and Sustainability: Do they mix?. - Linköping : Linköping University Electronic Press, Linköpings universitet.
  • Konferensbidrag (refereegranskat)
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