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- Mullins, N., et al.
(författare)
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Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
- 2021
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 53, s. 817-829
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Tidskriftsartikel (refereegranskat)abstract
- Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics. Integrating expression quantitative trait locus data implicated 15 genes robustly linked to bipolar disorder via gene expression, encoding druggable targets such as HTR6, MCHR1, DCLK3 and FURIN. Analyses of bipolar disorder subtypes indicated high but imperfect genetic correlation between bipolar disorder type I and II and identified additional associated loci. Together, these results advance our understanding of the biological etiology of bipolar disorder, identify novel therapeutic leads and prioritize genes for functional follow-up studies. Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.
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- Ching, C. R. K., et al.
(författare)
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What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group
- 2022
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Ingår i: Human Brain Mapping. - : Wiley. - 1065-9471 .- 1097-0193. ; 43:1, s. 56-82
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Tidskriftsartikel (refereegranskat)abstract
- MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large-scale meta- and mega-analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large-scale, collaborative studies of mental illness.
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- Kaufmann, Tobias, et al.
(författare)
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Common brain disorders are associated with heritable patterns of apparent aging of the brain
- 2019
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Ingår i: Nature Neuroscience. - : Nature Publishing Group. - 1097-6256 .- 1546-1726. ; 22:10, s. 1617-
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Tidskriftsartikel (refereegranskat)abstract
- Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
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- Elbe, A.-M., et al.
(författare)
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Career and Employment Survey for the Former Students of the European Master’s Programme in Sport and Exercise Psychology
- 2009
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Ingår i: Congrès International de Psychologie du Sport, Vincennes, 1-3 juillet 2009. - Paris : Institut National du Sport, de l'Expertise et de la Performance (INSEP). ; , s. 121-121
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The purpose of the European Master’s Programme in Sport and Exercise Psychology (EMPSEP) is to pool expertise of 12 European universities within one Master’s programme (see http://www.fepsac.com/). The 60 ECTS European programme provides students with advanced knowledge and skills. The EMPSEP comprises a joint intensive course, a study module similar in all the participating universities, lectures and seminars, a Master’s thesis, and a mobility period of 4-5 months at an EMPSEP host university. Ten years after the graduation of the first students the EMPSEP consortium conducted an online survey. Seventy of the invited 174 former students participated in the study (mean age 31.5 years, SD= 4.7). The aim of the survey was to discover the participants’ employment status and how their participation in the master’s program was related to this. Results indicate that 86% of the participants have started working since they completed their degree. Forty percent of those participants who have started working in their first job have managed to receive a permanent position, 27% a fixed term or temporary job, 25% a part time job, 6% are self employed and 1 person (2%) was employed by subsidies in his/ her first job after graduation. On a scale from extremely dissatisfied (1) to extremely satisfied (6), the participants rated their satisfaction with the program in relation to their career as 4.72 (SD=1.13) on average. Sixty nine of the participants felt that they had benefited from the international network provided by the students and teachers within the programme, and 94% would recommend the European Master’s program to other students in their field.
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