| 1. |
- Farnocchia, Davide, et al.
(författare)
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The Second International Asteroid Warning Network Timing Campaign: 2005 LW3
- 2023
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Ingår i: The Planetary Science Journal. - : Institute of Physics (IOP). - 2632-3338. ; 4:11
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Tidskriftsartikel (refereegranskat)abstract
- The Earth close approach of near-Earth asteroid 2005 LW3 on 2022 November 23 represented a good opportunity for a second observing campaign to test the timing accuracy of astrometric observation. With 82 participating stations, the International Asteroid Warning Network collected 1046 observations of 2005 LW3 around the time of the close approach. Compared to the previous timing campaign targeting 2019 XS, some individual observers were able to significantly improve the accuracy of their reported observation times. In particular, U.S. surveys achieved good timing performance. However, no broad, systematic improvement was achieved compared to the previous campaign, with an overall negative bias persisting among the different observers. The calibration of observing times and the mitigation of timing errors should be important future considerations for observers and orbit computers, respectively.
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| 2. |
- Bolin, Sara, 1988-, et al.
(författare)
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Dormant SOX9-positive cells behind MYC-driven medulloblastoma recurrence
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Tidskriftsartikel (refereegranskat)abstract
- Tumor recurrence is a slow biological process involving therapy resistance, immune escape, and metastasis and is the leading cause of death in medulloblastoma, the most frequent malignant pediatric brain tumor. By studying paired primary-recurrent patient samples and patient-derived xenografts we identified a significant accumulation of SOX9-positive cells in relapses and metastases. They exist as rare, quiescent cells in Group 3 and Group 4 patients that constitute two-thirds of medulloblastoma. To follow relapse at the single-cell level we developed an inducible dual Tet model of MYC-driven MB, where MYC can be directed from treatment-sensitive bulk cells to resistant, dormant SOX9-positive cells by doxycycline. SOX9 promoted immune es-cape, DNA repair suppression and was essential for recurrence. Tumor cell dormancy was non-hierarchical, migratory, and depended on MYC suppression by SOX9 to promote relapse. By using computational modeling and treatment we further showed how doxorubicin and MGMT inhibitors are specifically targeting relapsing cells.
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| 3. |
- Borgenvik, Anna, 1987-, et al.
(författare)
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Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
- 2022
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Ingår i: Cancer Research. - : AMER ASSOC CANCER RESEARCH. - 0008-5472 .- 1538-7445. ; 82:24, s. 4586-4603
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Tidskriftsartikel (refereegranskat)abstract
- Relapse is the leading cause of death in patients with medulloblas-toma, the most common malignant pediatric brain tumor. A better understanding of the mechanisms underlying recurrence could lead to more effective therapies for targeting tumor relapses. Here, we observed that SOX9, a transcription factor and stem cell/glial fate marker, is limited to rare, quiescent cells in high-risk medulloblastoma with MYC amplification. In paired primary-recurrent patient samples, SOX9-positive cells accumulated in medulloblastoma relapses. SOX9 expression anti-correlated with MYC expression in murine and human medulloblastoma cells. However, SOX9-positive cells were plastic and could give rise to a MYC high state. To follow relapse at the single-cell level, an inducible dual Tet model of medulloblastoma was developed, in which MYC expression was redirected in vivo from treatment-sensitive bulk cells to dormant SOX9-positive cells using doxycycline treatment. SOX9 was essential for relapse initiation and depended on suppression of MYC activity to promote therapy resistance, epithelial-mesenchymal transition, and immune escape. p53 and DNA repair pathways were downregulated in recurrent tumors, whereas MGMT was upregulated. Recurrent tumor cells were found to be sensitive to treatment with an MGMT inhibitor and doxorubicin. These findings suggest that recurrence-specific targeting coupled with DNA repair inhibition comprises a potential therapeutic strategy in patients affected by medulloblastoma relapse.Significance: SOX9 facilitates therapy escape and recurrence in medulloblastoma via temporal inhibition of MYC/MYCN genes, revealing a strategy to specifically target SOX9-positive cells to prevent tumor relapse.
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| 4. |
- Jiang, Frank, et al.
(författare)
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SVEA : an experimental testbed for evaluating V2X use-cases
- 2022
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Ingår i: 2022 IEEE 25TH INTERNATIONAL CONFERENCE ON INTELLIGENT TRANSPORTATION SYSTEMS (ITSC). - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 3484-3489
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Konferensbidrag (refereegranskat)abstract
- In this paper, we present a hardware and software testbed designed for evaluating vehicle-to-everything (V2X) usecases. From platooning to remote driving, there are many proposals to use V2X communication to solve sustainability or safety issues in transport networks. However, researchers mostly evaluate their proposals in only simulation studies, since setting up real, full-scale field tests can often be prohibitively expensive or time-consuming. The open-sourced Small Vehicles for Autonomy (SVEA) testbed is built around a communication software stack and a 1/10th-scale automated vehicle platform suitable for both cost-effective and time-efficient experimentation with V2X use-cases. The testbed is designed to support evaluation in a wide range of conditions, such as heterogeneous networks or vehicle fleets. To illustrate the suitability of the SVEA testbed for studying V2X use-cases, we detail and implement three use-cases: platooning, adaptive speed regulation from a road-side infrastructure camera, and remote-driving by a human operator sitting in a control tower. Finally, we conclude the paper with a discussion on the use of the platform so far and future development plans.
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| 5. |
- Sõmersalu, Liisa, 1983-
(författare)
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Civic Cultures in Eastern Europe : Communication spaces and media practices of Estonian civil society organizations
- 2022
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- What kind of routine media and communication practices do Estonian civil society organizations enact in their everyday work? What sort of symbolic and physical spaces are used, created, and accessed by Estonian civil society organizations and informal citizen groups when engaging internally and with their target groups? How do these spaces and practices evolve over time? These are the questions this dissertation addresses, with the aim of understanding the ways in which already-established and evolving civil society organizations navigate the highly-mediated everyday through their routine media practices and the spaces in which these practices are situated.Theoretically, this study takes a cultural approach to political participation with the concept of ‘civic cultures’ (Dahlgren 2009, p. 103) in the centrum. In this dissertation, the civic cultures framework is concentrated into a focus on the everyday, on media practices, and on communicative spaces. The concepts of ‘everyday’ and ‘spaces’ are empirically accessed through a practice approach. To distill and explore the role of media in the everyday work of civil society organizations, this thesis borrows from “activist media practices” (Mattoni 2012, p. 159) framework.The empirical study is grounded in the wider geopolitical context of Eastern Europe and in the historical context of post-Soviet Europe, and more specifically in Estonian civil society. Using a multi-methods approach based on media ethnography, this study includes a nationally-representative survey, in-depth interviews with civil society organizations, and a longitudinal study of the Estonian Forest Aid movement.This study found that parallel to striving towards episodic visibility in physical spaces, in mainstream media, and in decision making, civil society organizations worked on constant visibility in the social media space. The most used social media platform, Facebook, proved to be an important space for developing civic cultures on an everyday level: it was used for campaigns, opinion shaping, for disseminating news, and for civic talk. Everyday communication within the organizations was done using a mix of different media technologies and face-to-face meetings. Each media technology and communicative space had their own role and function in the everyday work of Estonian civil society organizations.
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