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- Ayeni, O. R., et al.
(författare)
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Clinical and Radiographic Criteria Define "Acceptable" Surgical Correction of Hip Femoroacetabular Impingement Syndrome as Well as Postoperative Complications: An International Modified Delphi Study
- 2023
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Ingår i: Arthroscopy-the Journal of Arthroscopic and Related Surgery. - : Elsevier BV. - 0749-8063. ; 39:5, s. 1198-1210
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To develop recommendations for clinical and radiographic criteria to help define the "acceptable" surgical correction of femoroacetabular impingement syndrome (FAIS) and identify/define complications postoperatively. Methods: A 3-phase modified Delphi study was conducted involving a case-based survey; a Likert/multiple choice-based survey concerning radiographic and physical examination characteristics to help define FAIS correction, as well as the prevalence and definition of potential postoperative complications; and 2 consensus meetings. Results: Of the 75 experts invited, 54 completed the Phase I survey, 50 completed the Phase II survey (72% and 67% response rate), and 50 participated in the Phase III consensus meetings. For both typical and atypical (complex) cases, there was consensus that fluoroscopy with multiple views and dynamic hip assessment should be used intraoperatively (96% and 100%, respectively). For typical FAIS cases, the Expert Panel agreed that Dunn lateral and anteroposterior radiographs were the most important radiographs to evaluate the hip postoperatively (88%, consensus). When asked about evaluating the correction of cam impingement postoperatively, 87% voted that they use subjective evaluation of the "sphericity" of the femoral head. In the case of focal and global pincer-type FAIS, there was consensus that the reduction or elimination of the crossover sign (84%) and lateral center-edge angle (91%) were important to inform the extent of the FAIS correction. There was consensus for recommending further investigation at 6 months postoperatively if hip pain had increased/plateaued (92% agreed); that additional investigation and treatment should occur between 6 and 12 months (90% agreed); and that a reoperation may be recommended at 12 months or later following this investigation period (89% agreed). Conclusions: This consensus project identified the importance of using fluoroscopy and dynamic hip assessment intraoperatively; Dunn lateral and anteroposterior view radiographs postoperatively; evaluating the "sphericity" of the femoral head for cam-type correction and the use of dynamic hip assessment; reducing/eliminating the crossover sign for focal pincertype FAIS; evaluating the lateral center-edge angle for global pincer-type FAIS; and avoiding overcorrection of pincer-type FAIS. In cases in which postoperative hip pain increased/plateaued, further investigation and treatment is warranted between 6 and 12 months, and a reoperation may be recommended at a minimum of 12 months depending on the cause of the hip pain. Clinical Relevance: Hip arthroscopy surgeons have yet to reach a firm agreement on what constitutes an "acceptable" or "good" surgery radiographically and how they can achieve desired clinical outcomes. Although this was a comprehensive effort, more study is needed to determine therapeutic thresholds that can be universally applied.
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- da Silva, Stéphanie
(författare)
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Conséquences d’un stress chronique sur la barrière de mucus intestinal chez le rat : effet du probiotique Lactobacillus farciminis
- 2013
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background. Despite a large body of literature incriminating mucus alterations in the pathogenesis of Intestinal Bowel Diseases (IBD), structural and physical changes in the mucus layer remain poorly understood in the micro-inflammatory context of Irritable Bowel Syndrome (IBS). Moreover, some probiotic treatments prevent stress-induced intestinal epithelial barrier impairment but little is known about their influence on intestinal mucin structural modifications and mucus properties induced by stress. Thereby, this study aimed at evaluating whether (i) a chronic stress modified the number of gut goblet cells and Muc2 expression and O-glycosylation, (ii) L. farciminis (LF) treatment prevented these alterations and (iii) observed effects were related to the in vivo colonization capacity of LF.Main results and conclusions. Water Avoidance Stress (WAS) did not modify neither the number of intestinal goblet cells nor Muc2 expression. Mass Spectrometry analysis demonstrated that O-glycosylation of mucins was strongly affected by WAS, and confirmed in another model of IBS (maternal deprivation model). Under stress conditions, the mucus layer, showed a flattened morphology, probably indicative of a loss in its cohesive properties. The mucus layer alteration was, thus, in relation with epithelial barrier impairment and visceral hypersensitivity. LF administration prevented WAS-induced functional, biochemical and physical changes of mucus. The presence of LF in the ileum and colon was confirmed and we observed that Segmented Filamentous Bacteria (SFB) population was reduced by LF.Chronic stress induced functional changes in rats, as well as a shift in mucin O-glycosylation rather than changes in mucin expression, resulting in a loss of mucus layer cohesive properties. These results confirm that LF is a valuable probiotic in the IBS management.Methods. IBS Animal model (WAS and maternal deprivation), histological, Mass Spectrometry, Microscopy (Fluorescence, AFM, SEM and TEM), bacterial localization by Fluorescence In Situ Hybridization (FISH), qPCR, intestinal paracellular permeability, visceral sensitivity.
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- SHELDON, RW, et al.
(författare)
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NANOPLANKTON AND PICOPLANKTON GROWTH AND PRODUCTION IN THE BAY OF VILLEFRANCHE-SUR-MER (NW MEDITERRANEAN)
- 1992
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Ingår i: Hydrobiologia. - 0018-8158 .- 1573-5117. ; 241:2, s. 91-106
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Tidskriftsartikel (refereegranskat)abstract
- Plankton production in the Bay of Villefranche was relatively constant during March and April 1986 but the particle size at which the production occurred was more variable. At the beginning of the study, production was dominated by the larger (ca. 6 mum) flagellates but towards the end it was more or less equally divided between the nano- and picoplankton. There were considerable differences in the estimates of population growth rates, depending on the methods used, but on average the population doubling times were close to 12 hours for autotrophs and 24 hours for heterotrophs. As autotrophs do not grow during the night, each population was therefore doubling once per day. It seemed that each of the nano- or picoplankton populations could adversely affect the growth of the others. This could be either by simple predation or by some form of inhibition. Although nutrient levels in the bay were uniformly low, the addition of nutrients did not always stimulate algal growth. The plankton populations seemed to be both in a state of equilibrium and intense ecological competition.
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