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- Borgström, Birgit, et al.
(författare)
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Fertility preservation in girls with turner syndrome : prognostic signs of the presence of ovarian follicles
- 2009
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 94:1, s. 74-80
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Tidskriftsartikel (refereegranskat)abstract
- CONTEXT: Many girls with Turner syndrome have follicles in their ovaries at adolescence. Objective: Our objective was to study which girls might benefit from ovarian tissue freezing for fertility preservation. Design: Clinical and laboratory parameters and ovarian follicle counts were analyzed among girls referred by 25 pediatric endocrinologists. SUBJECTS AND SETTING: Fifty-seven girls with Turner syndrome, aged 8-19.8 yr, were studied at a university hospital. Interventions: Ovarian tissue was biopsied laparoscopically, studied for the presence of follicles, and cryopreserved. Blood samples were drawn for hormone measurements. MAIN OUTCOME MEASURES: Presence of follicles in the biopsied tissue related to age, signs of spontaneous puberty, karyotype, and serum concentrations of gonadotropins and anti-Müllerian hormone were assessed. RESULTS: Ovarian biopsy was feasible in 47 of the 57 girls. In 15 of the 57 girls (26%), there were follicles in the tissue piece analyzed histologically. Six of seven girls (86%) with mosaicism, six of 22 (27%) with structural chromosomal abnormalities, and three of 28 with karyotype 45X (10.7%) had follicles. Eight of the 13 girls (62%) with spontaneous menarche had follicles, and 11 of the 19 girls (58%) who had signs of spontaneous puberty had follicles. The age group 12-16 yr had the highest proportion of girls with follicles. Normal FSH and anti-Müllerian hormone concentrations for age and pubertal stage were more frequent in girls with follicles. CONCLUSIONS: Signs of spontaneous puberty, mosaicism, and normal hormone concentrations were positive and statistically significant but not exclusive prognostic factors as regards finding follicles.
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- Ejderhamn, Jan, et al.
(författare)
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[Somatic complications of anorexia nervosa in children and adolescents. Prognosis is good if the patient achieves normal weight within a couple of years] : Somatiska komplikationer vid anorexia nervosa hos barn och unga. God prognos om patienten blir normalviktig inom ett par år.
- 2005
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Ingår i: Läkartidningen. - 0023-7205. ; 102:36, s. 2464-7
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Forskningsöversikt (refereegranskat)abstract
- This article presents an overview of somatic complications in anorexia nervosa in children and adolescents. Cardiovascular-, gastrointestinal-, and endocrine- complications are often observed as a consequence of starvation in anorexia nervosa, Prolongation of QT interval can cause fatal arrhythmias. Checking levels of serum electrolytes, phosphate and magnesium daily during initial phase of refeeding is necessary to avoid the Refeeding syndrome. The activity of the thyroid gland and the gonads is depressed. The patients will remain or return to a prepubertal status with poor growth and low levels of sex hormones. This, in addition to low IGF-I, low adrenal androgens and lack of energy, may result in subnormal development of bone density. If anorexia nervosa starts early in life and continues for many years there will not be a full recovery, resulting in osteoporosis and a decrease of final height. The other complications however have a good prognosis when food intake is normalised.
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