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Sökning: WFRF:(Borgström Julia)

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2.
  • Becker, Bo, et al. (författare)
  • Telia's Bid for Bonnier Broadcasting
  • 2020
  • Patent (övrigt vetenskapligt/konstnärligt)abstract
    • In July 2018, Telia was the Nordic region's dominant telecommunications company, with almost 17 million mobile (cell phone) subscriptions, almost 3 million broadband customers and operating cash flow of more than EUR1 billion. The next generation 5G network equipment promised to generate growing demand for bandwidth. Yet, Telia faced several challenges. The year before, Telia had settled corruption charges related to Central Asian operations with total sanctions of almost one billion Euro, and the organization was being revamped to improve the culture. For the long term, bandwidth risked commoditization, customer churn was increasing for telecommunications services, and Telia's management feared margins were moving away from distribution toward content provision. Now, after extended negotiations, Telia had the opportunity to acquire Bonnier Broadcasting, a TV company with both broadcast and streaming operations. The deal would be a unique opportunity to combine distribution with content, and would include the growing streaming service C More in Telia's portfolio, as well as Sweden's second largest broadcast television channel, TV4. Synergies could be large, but the integration posed formidable challenges. A deal was on the table for SEK10.2 Billion. Now CEO Johan Dennelind and his management team had to decide whether to sign the agreement.
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3.
  • Sandberg, Julia, et al. (författare)
  • Interrogation of polyguaninine nucleotide repeat variability in human T-cells by whole genome sequencing of single cells
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Polyguanine nucleotide repeats exhibit a greater degree of variation than the average for the genome as a whole. This is partly due to polymerase slippage that causes insertions or deletions in these repeat sequence. The high variability of these repeats makes them useful for tracking the differentiation and fate of cells within tissues and organs. However, the same factors that create this variability also give rise to technical difficulties in DNA amplification and massively parallel DNA sequencing. In the study reported herein, we investigated shotgun sequence data from a standard multi-cell sample as well as sequence data for four single cells from the same individual. This was used to assess sequence quality in whole genome amplified single cell material and to investigate variability in homopolymeric regions between individual T-cells. In a more focused study, a selected set of polyG loci in single cells for which the phylogenetic relationship was known, were amplified and sequence determined. Based on the length differences in polyG repeats between the eight cells a phylogenetic tree was constructed, that was very similar to the known tree.
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