| 1. |
- Agnoletti, Davide, et al.
(författare)
-
Microbiota, Diet, Oral Health and Vascular Aging
- 2024. - 2
-
Ingår i: Early Vascular Aging (EVA) : New Directions in Cardiovascular Protection - 2nd Edition - New Directions in Cardiovascular Protection - 2nd Edition. - 9780443155123
-
Bokkapitel (refereegranskat)
|
|
| 2. |
- Bouchard, Phillipe, et al.
(författare)
-
European workshop in periodontal health and cardiovascular disease consensus document
- 2010
-
Ingår i: European Heart Journal, Supplement. - 1520-765X .- 1554-2815. ; 12:B, s. B13-B22
-
Tidskriftsartikel (refereegranskat)abstract
- There is evidence from epidemiological research on the association between periodontal diseases (PD) and cardiovascular disease (CVD). In spite of these significant associations, however, there is still a lack of awareness in the cardiovascular community on their possible importance. In view of this evidence, an expert panel composed by six European periodontists and four cardiologists addressed the following questions: a) How important is the association of PD and CVD?; b) How do we measure exposure (PD) and outcome (CVD)?; c) What is the pathogenic link?; d) What is the relative importance of periodontal therapy as prevention of CVD?; e) Is it justified to recommend periodontal health with the goal of reducing CV risk?; f) What clinical and experimental research is needed?. The general conclusions were that even though these proven epidemiological association between PD and CVD, there is, however, no compelling evidence that preventive periodontal care or therapeutic intervention will influence cardiac health. As Periodontitis continues to have a high prevalence within the population and the fact that CVD remains as the major cause of human death in developed countries, in light of these associations we can legitimately, based on evidence, state that oral health has an influence on systemic health in general and in CVD in particular, and therefore, we should promote oral health in general and periodontal health in particular as part of a healthy life style and hence as an important component in the prevention of CVD.
|
|
| 3. |
- Bouchard, Phillipe, et al.
(författare)
-
European workshop in periodontal health and cardiovascular disease consensus document
- 2010
-
Ingår i: European Heart Journal, Supplement. - : Oxford University Press. - 1520-765X. ; 12:B, s. B13-B22
-
Tidskriftsartikel (refereegranskat)abstract
- There is evidence from epidemiological research on the association between periodontal diseases (PD) and cardiovascular disease (CVD). In spite of these significant associations, however, there is still a lack of awareness in the cardiovascular community on their possible importance. In view of this evidence, an expert panel composed by six European periodontists and four cardiologists addressed the following questions: a) How important is the association of PD and CVD?; b) How do we measure exposure (PD) and outcome (CVD)?; c) What is the pathogenic link?; d) What is the relative importance of periodontal therapy as prevention of CVD?; e) Is it justified to recommend periodontal health with the goal of reducing CV risk?; f) What clinical and experimental research is needed?. The general conclusions were that even though these proven epidemiological association between PD and CVD, there is, however, no compelling evidence that preventive periodontal care or therapeutic intervention will influence cardiac health. As Periodontitis continues to have a high prevalence within the population and the fact that CVD remains as the major cause of human death in developed countries, in light of these associations we can legitimately, based on evidence, state that oral health has an influence on systemic health in general and in CVD in particular, and therefore, we should promote oral health in general and periodontal health in particular as part of a healthy life style and hence as an important component in the prevention of CVD.
|
|
| 4. |
- Bruno, Rosa Maria, et al.
(författare)
-
Early and supernormal vascular aging : Clinical characteristics and association with incident cardiovascular events
- 2020
-
Ingår i: Hypertension. - 0194-911X. ; , s. 1616-1624
-
Tidskriftsartikel (refereegranskat)abstract
- Pulse wave velocity is an established marker of early vascular aging but may also help identifying individuals with supernormal vascular aging. We tested the hypothesis that individuals with the largest difference (Δ-age) between chronological and vascular age show the lowest rate of cardiovascular events and may thus be defined as supernormal vascular aging. Vascular age was defined as the predicted age in the best fitting multivariable regression model including classical risk factors and treatment and pulse wave velocity, in a subset of the Reference Values for Arterial Stiffness Collaboration Database (n=3347). Δ-age was then calculated as chronological age minus vascular age, and the 10th and 90th percentiles were used to define early (Δ-age<-5.7 years), normal (Δ-age -5.7 to 6.8 years) and supernormal vascular aging (Δ-age>6.8 years). The risk for fatal and nonfatal cardiovascular events associated with vascular aging categories was investigated in the Malmö Diet and Cancer Study cohort (n=2642). In the Malmö Diet and Cancer Study Cohort (6.6-year follow-up, 286 events), Δ-age was significantly (P<0.01) and inversely associated with cardiovascular events. Compared with normal vascular aging, supernormal vascular aging had lower risk (hazard ratio, 0.59 [95% CI, 0.41-0.85]), whereas early vascular aging had higher risk (hazard ratio, 2.70 [95% CI, 1.55-4.70]) of cardiovascular events, in particular coronary events. There was no significant association with all-cause mortality. This study represents the first validation of the clinical significance of the supernormal vascular aging concept, based on prospective data. Its further characterization may help discovering novel protective molecular pathways and providing preventive strategies for successful vascular aging.
|
|
| 5. |
- Cunha, Pedro G, et al.
(författare)
-
Early vascular ageing (EVA) : Definitions and clinical applicability
- 2017
-
Ingår i: Current Hypertension Reviews. - : Bentham Science Publishers Ltd.. - 1573-4021. ; 13:1, s. 8-15
-
Forskningsöversikt (refereegranskat)abstract
- Arterial stiffness has been accumulating evidence as an intermediate cardiovascular endpoint. It has been established as an independent risk marker for cardiovascular disease, and reflects the dissociation between chronologic and biologic age of large arteries-attributing earlier the risk that a normal vascular ageing process had installed to occur several years later. The concept of Early Vascular Ageing (EVA) is developed to establish primordial prevention, identifying individuals whose ageing path has been accelerated either by inherent features, interaction with the environment or arterial exposure to several types of insults that evolve to medial layer morphological changes. Understanding the pathophysiology of vascular ageing, its consequences and therapeutic opportunities is therefore an advantage that could be translated in time of prevention and survival free of cardiovascular disease. As the EVA construct is advancing, new features appear as interesting to better translate it into clinical practice.
|
|
| 6. |
- Cunha, Pedro G, et al.
(författare)
-
Pulse wave velocity distribution in a cohort study: from arterial stiffness to early vascular aging.
- 2015
-
Ingår i: Journal of Hypertension. - 1473-5598. ; 33:7, s. 1438-1445
-
Tidskriftsartikel (refereegranskat)abstract
- By contrast with other southern European people, north Portuguese population registers an especially high prevalence of hypertension and stroke incidence. We designed a cohort study to identify individuals presenting accelerated and premature arterial aging in the Portuguese population.
|
|
| 7. |
- Herbert, Annie, et al.
(författare)
-
Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors.
- 2014
-
Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 35:44, s. 3122-33
-
Tidskriftsartikel (refereegranskat)abstract
- AIMS: Estimated central systolic blood pressure (cSBP) and amplification (Brachial SBP-cSBP) are non-invasive measures potentially prognostic of cardiovascular (CV) disease. No worldwide, multiple-device reference values are available. We aimed to establish reference values for a worldwide general population standardizing between the different available methods of measurement. How these values were significantly altered by cardiovascular risk factors (CVRFs) was then investigated.METHODS AND RESULTS: Existing data from population surveys and clinical trials were combined, whether published or not. Reference values of cSBP and amplification were calculated as percentiles for 'Normal' (no CVRFs) and 'Reference' (any CVRFs) populations. We included 45,436 subjects out of 82,930 that were gathered from 77 studies of 53 centres. Included subjects were apparently healthy, not treated for hypertension or dyslipidaemia, and free from overt CV disease and diabetes. Values of cSBP and amplification were stratified by brachial blood pressure categories and age decade in turn, both being stratified by sex. Amplification decreased with age and more so in males than in females. Sex was the most powerful factor associated with amplification with 6.6 mmHg (5.8-7.4) higher amplification in males than in females. Amplification was marginally but significantly influenced by CVRFs, with smoking and dyslipidaemia decreasing amplification, but increased with increasing levels of blood glucose.CONCLUSION: Typical values of cSBP and amplification in a healthy population and a population free of traditional CVRFs are now available according to age, sex, and brachial BP, providing values included from different devices with a wide geographical representation. Amplification is significantly influenced by CVRFs, but differently in men and women.
|
|
| 8. |
- Laurent, Stephane, et al.
(författare)
-
Concept of Extremes in Vascular Aging
- 2019
-
Ingår i: Hypertension. - 1524-4563. ; 74:2, s. 218-228
-
Forskningsöversikt (refereegranskat)abstract
- With advancing age, changes in the arterial wall contribute to what has been called vascular aging, and in some prematurely affected subjects even early vascular aging (EVA).1–5 Several years ago,1 we listed various components of EVA, including arteriosclerosis, atherosclerosis, and excess vasoconstriction, with their clinical expression: arterial stiffening and increased central pulse pressure, carotid intima media thickening and endothelial dysfunction, and increased total peripheral resistance, respectively. In this review, we focus on arteriosclerosis, ie, arterial stiffening, for several reasons: this is the most characteristic clinical feature of the aging process of the arterial system,6 its measurement has been well standardized and referenced,7,8 and an increasing number of epidemiological studies have analyzed its independent determinants.9–11 Increased pulse wave velocity (PWV) is the established hallmark of arterial stiffening and is suggested to be one of the best biomarkers available to calculate the prospective cardiovascular risk and mortality risk of an individual.9,10,12,13 EVA can be diagnosed in subjects who present an abnormally high arterial stiffness for their age and sex.In the present review, we propose the concept of supernormal vascular aging (SUPERNOVA). SUPERNOVA can be diagnosed in subjects who present an exceptionally low arterial stiffness for their age and sex. We address the issue of the metrics and definition of EVA and SUPERNOVA as 2 extremes of the distribution of vascular aging. We discuss the concept of extremes in cardiometabolic research. Further, we review the molecular basis and mechanobiology of EVA and SUPERNOVA, in parallel with their epidemiological, genetic, and epigenetic determinants. Finally, we suggest therapeutic options and insist on the need for discovering novel molecular targets for slowing arterial aging and protecting against cardiovascular complications. By choosing the wording SUPERNOVA, we referred to the life of a supernova—a large explosion that takes place at the end of a star’s life cycle. The relationship between supernova and black hole is not firmly established, but physics theory states that in a black hole, time is slowed…like aging of arteries in SUPERNOVA subjects.
|
|
| 9. |
- Nilsson, Peter, et al.
(författare)
-
Early vascular ageing in translation: from laboratory investigations to clinical applications in cardiovascular prevention.
- 2013
-
Ingår i: Journal of Hypertension. - 1473-5598. ; 31:8, s. 1517-1526
-
Forskningsöversikt (refereegranskat)abstract
- The ageing of the vascular tree is a fundamental reflection of biological ageing in general and a determinant of organ function. In the arterial wall this is characterized by a reduction in the elastin content, as well as by an increased content of collagen and its cross-linkages, leading to increased arterial stiffness and elevated central as well as brachial blood pressure, accompanied by increased SBP variability. In recent years a better understanding of these processes have led to the proposal of a condition named early vascular ageing (EVA) in patients with increased arterial stiffness for their age and sex. This is a condition that could increase cardiovascular risk and is associated with various degrees of cognitive dysfunction, as well as other features of biological ageing. This brief review aims to give an update on EVA and how the concept can be used in clinical practice.
|
|
| 10. |
- Nilsson, Peter M., et al.
(författare)
-
Characteristics of healthy vascular ageing in pooled population-based cohort studies : the global Metabolic syndrome and Artery REsearch Consortium
- 2018
-
Ingår i: Journal of Hypertension. - 1473-5598. ; 36:12, s. 2340-2349
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Arterial ageing is characterized by increasing arterial stiffness as measured by pulse wave velocity (PWV). This process is enhanced in participants with early vascular ageing (EVA), but slowed in participants with healthy vascular ageing (HVA). We aimed to describe characteristics of EVA and HVA in a transcontinental study including 11 cohorts.METHODS: In all, 18 490 participants from the global MARE Consortium, free of cardiovascular disease, participated with data on PWV and cardiometabolic risk factors. We defined HVA as the lowest 10% and EVA as the highest 10% of the standardized PWV distribution, adjusted for age intervals. HVA individuals were compared with the 90% of non-HVA individuals with ANCOVA, adjusted for age, sex and hypertension.RESULTS: The 1723 HVA participants were at the same age as the rest of the population, more likely women (59.4 vs 57.0%), and with significantly lower levels of established cardiovascular risk factors (blood pressure, lipids, glucose). Similarly, the prevalence rate of obesity, diabetes mellitus, hypertension and the metabolic syndrome was lower in the HVA participants. In the presence of similar levels of cardiovascular risk factors, HVA participants in the 50-64 years of age group presented lower PWV 5.8 (SD 0.5) vs. 7.4 (1.4) m/s (P < 0.0001) than control individuals in the 35-49 years of age group, corresponding to an estimated difference in chronological age of 14 years.CONCLUSION: Participants with healthy vascular ageing (HVA), belonging to the lowest end of the PWV distribution, are in general characterized by an up to 14 years estimated younger biological (vascular) age than those with higher PWV values, and have lower levels of risk factors.
|
|
