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Sökning: WFRF:(Bowler Peter A.)

  • Resultat 1-4 av 4
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1.
  • Sakornsakolpat, Phuwanat, et al. (författare)
  • Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
  • 2019
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 51:3, s. 494-505
  • Tidskriftsartikel (refereegranskat)abstract
    • Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 controls from the UK Biobank and additional studies from the International COPD Genetics Consortium. We identified 82 loci associated with P < 5 x 10-8; 47 of these were previously described in association with either COPD or population-based measures of lung function. Of the remaining 35 new loci, 13 were associated with lung function in 79,055 individuals from the SpiroMeta consortium. Using gene expression and regulation data, we identified functional enrichment of COPD risk loci in lung tissue, smooth muscle, and several lung cell types. We found 14 COPD loci shared with either asthma or pulmonary fibrosis. COPD genetic risk loci clustered into groups based on associations with quantitative imaging features and comorbidities. Our analyses provide further support for the genetic susceptibility and heterogeneity of COPD.
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2.
  • Balint, Miklos, et al. (författare)
  • Environmental DNA time series in ecology
  • 2018
  • Ingår i: Trends in Ecology & Evolution. - London : Elsevier. - 0169-5347 .- 1872-8383. ; 33:12, s. 945-957
  • Forskningsöversikt (refereegranskat)abstract
    • Ecological communities change in time and space, but long-term dynamics at the century-to-millennia scale are poorly documented due to lack of relevant data sets. Nevertheless, understanding long-term dynamics is important for explaining present-day biodiversity patterns and placing conservation goals in a historical context. Here, we use recent examples and new perspectives to highlight how environmental DNA (eDNA) is starting to provide a powerful new source of temporal data for research questions that have so far been overlooked, by helping to resolve the ecological dynamics of populations, communities, and ecosystems over hundreds to thousands of years. We give examples of hypotheses that may be addressed by temporal eDNA biodiversity data, discuss possible research directions, and outline related challenges.
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3.
  • Bowler, Peter A., et al. (författare)
  • A role for ecological restoration work in university environmental education
  • 1999
  • Ingår i: Journal of Environmental Education. - 0095-8964. ; 30:4, s. 19-26
  • Tidskriftsartikel (refereegranskat)abstract
    • The effects of ecological restoration field work and in-class instruction on students’ ecological behavior, environmental attitudes, and perceptions of restorative qualities in a natural environment were studied in 3 classes of university undergraduates (
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  • Resultat 1-4 av 4

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