| 1. |
- Abbafati, Cristiana, et al.
(författare)
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- 2020
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Tidskriftsartikel (refereegranskat)
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| 2. |
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| 3. |
- Nicolas, Aude, et al.
(författare)
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Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
- 2018
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Ingår i: Neuron. - : Cell Press. - 0896-6273 .- 1097-4199. ; 97:6, s. 1268-1283.e6
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Tidskriftsartikel (refereegranskat)abstract
- To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS.
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| 4. |
- Brady, Tim, et al.
(författare)
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Making Sense of Learning Landscapes in Project-Based Organizations
- 2005
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Ingår i: Managing Knowledge in Project Environments. - Oxford : ButterworthHeinemann/ Elsevier. - 9780750662512 - 0750662514 ; , s. 197-217
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Management of knowledge in project environments is a unique text that brings together contributions from leading academic practitioners, to demonstrate how the management of knowledge can lead to project success in today's complex and changing business environment.The work examines how the management of knowledge, particularly the sharing of knowledge and the importance of learning through reflection, can lead to project success and improved business performance. This book is written by an international contributor team and offers practical applications, models and case studies from a variety of international perspectives.* Demonstrates how the management of knowledge can lead to success in project outcomes* Highlights the importance of inter- and intra- organizational learning* Incorporates international case studies to demonstrate how knowledge can be effectively managed
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| 7. |
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KTHA #1
- 2010
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Samlingsverk (redaktörskap) (populärvet., debatt m.m.)abstract
- Innehåll|Contents"Gunnar Henriksson: Mannen bakom allt", Ola Andersson, Hans Loord"Nittonhundraåttiofem" Ola Andersson"Landscape as a Body (To Dress)", Katja Grillner"Nya Slussen", Daniel Johansson, Johanna Håkansdotter- Karlsson, Tor Lindstrand, Martin Losos, Victor Mickelsson, Sara Vall, Ann-Charlotte Wiklander, Frida Öhlin"Patchwork: Albano Sustainable Campus", Stephan Bartel, Johan Colding, Hanna Erixon, Henrik Ernstson, Sara Grahn, Matts Ingman, Carl Kärsten, Lars Marcus, Jonas Torsvall"Multireligiös begravningsplats på Järva friområde", Henrik Vogt"Bridging the Gap", Alexis Pontvik"Tullinge Idea Store: Plats, struktur, program" Jesús Azpeitia"Treasures from the Archive: Der Städtebau nach seinen künstlerischen Grundsätzen, Camillo Sitte", Anders Bergström"Reading Architecture and Beauty: Conversations with Architects about a Troubled Relationship, Yael Reisner with Fleur Watson", Frida Rosenberg"Leon Battista Alberti, Identical Copies, and the Early Modern Invention of Architectural Design", Mario Carpo"Three Concepts of Performative Design: Proturbance, Porosity, Venation", Marcelyn Gow, Ulrika Karlsson, Daniel Norell
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| 8. |
- Lundin, Rolf A., et al.
(författare)
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Managing and working in Project Society : Institutional Challenges of Temporary Organizations
- 2015. - 1
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- In this book, leading authorities on project organizing explore the growing deployment of projects and other types of temporary organizations, with a focus on the challenges created by projectification. The way projects are coordinated and handled influences the success of innovation and change within organizations and is critical for strategic development in our societies, yet it is often at odds with the institutions of traditional industrial society. Drawing on both theoretical perspectives and real-world cases, this book sheds light on the transformation toward a project society and explores the effects, opportunities, and conflicts it has created. As change continues, the authors make a case for renewing institutions and mind-sets and provide a foundation from which to discuss societal changes for the future. This is an invaluable book for researchers and students in project management and organizational theory programs, as well as professionals involved in the management of projects.
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| 9. |
- Mills, Katherine, et al.
(författare)
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Comorbidity: Trauma, substance use and mental health
- 2022
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Ingår i: Drug and Alcohol Review. - : Wiley. - 0959-5236 .- 1465-3362. ; 41, s. 15-15
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Konferensbidrag (refereegranskat)abstract
- Substance use and mental health disorders commonly co-occur and they are frequently underpinned by history of psychological trauma. This symposium presents new data on the clinical presentation and documentation of trauma exposure, trauma-related disorders, and their treatment among adults entering substance use treatment, the implementation of integrated trauma-focused therapy in substance use treatment, and presenting issues among adolescents seeking integrated treatment for substance use and traumatic stress.
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| 10. |
- Murray, Christopher J. L., et al.
(författare)
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Population and fertility by age and sex for 195 countries and territories, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017
- 2018
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Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 392:10159, s. 1995-2051
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Tidskriftsartikel (refereegranskat)abstract
- Background: Population estimates underpin demographic and epidemiological research and are used to track progress on numerous international indicators of health and development. To date, internationally available estimates of population and fertility, although useful, have not been produced with transparent and replicable methods and do not use standardised estimates of mortality. We present single-calendar year and single-year of age estimates of fertility and population by sex with standardised and replicable methods. Methods: We estimated population in 195 locations by single year of age and single calendar year from 1950 to 2017 with standardised and replicable methods. We based the estimates on the demographic balancing equation, with inputs of fertility, mortality, population, and migration data. Fertility data came from 7817 location-years of vital registration data, 429 surveys reporting complete birth histories, and 977 surveys and censuses reporting summary birth histories. We estimated age-specific fertility rates (ASFRs; the annual number of livebirths to women of a specified age group per 1000 women in that age group) by use of spatiotemporal Gaussian process regression and used the ASFRs to estimate total fertility rates (TFRs; the average number of children a woman would bear if she survived through the end of the reproductive age span [age 10–54 years] and experienced at each age a particular set of ASFRs observed in the year of interest). Because of sparse data, fertility at ages 10–14 years and 50–54 years was estimated from data on fertility in women aged 15–19 years and 45–49 years, through use of linear regression. Age-specific mortality data came from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 estimates. Data on population came from 1257 censuses and 761 population registry location-years and were adjusted for underenumeration and age misreporting with standard demographic methods. Migration was estimated with the GBD Bayesian demographic balancing model, after incorporating information about refugee migration into the model prior. Final population estimates used the cohort-component method of population projection, with inputs of fertility, mortality, and migration data. Population uncertainty was estimated by use of out-of-sample predictive validity testing. With these data, we estimated the trends in population by age and sex and in fertility by age between 1950 and 2017 in 195 countries and territories. Findings: From 1950 to 2017, TFRs decreased by 49·4% (95% uncertainty interval [UI] 46·4–52·0). The TFR decreased from 4·7 livebirths (4·5–4·9) to 2·4 livebirths (2·2–2·5), and the ASFR of mothers aged 10–19 years decreased from 37 livebirths (34–40) to 22 livebirths (19–24) per 1000 women. Despite reductions in the TFR, the global population has been increasing by an average of 83·8 million people per year since 1985. The global population increased by 197·2% (193·3–200·8) since 1950, from 2·6 billion (2·5–2·6) to 7·6 billion (7·4–7·9) people in 2017; much of this increase was in the proportion of the global population in south Asia and sub-Saharan Africa. The global annual rate of population growth increased between 1950 and 1964, when it peaked at 2·0%; this rate then remained nearly constant until 1970 and then decreased to 1·1% in 2017. Population growth rates in the southeast Asia, east Asia, and Oceania GBD super-region decreased from 2·5% in 1963 to 0·7% in 2017, whereas in sub-Saharan Africa, population growth rates were almost at the highest reported levels ever in 2017, when they were at 2·7%. The global average age increased from 26·6 years in 1950 to 32·1 years in 2017, and the proportion of the population that is of working age (age 15–64 years) increased from 59·9% to 65·3%. At the national level, the TFR decreased in all countries and territories between 1950 and 2017; in 2017, TFRs ranged from a low of 1·0 livebirths (95% UI 0·9–1·2) in Cyprus to a high of 7·1 livebirths (6·8–7·4) in Niger. The TFR under age 25 years (TFU25; number of livebirths expected by age 25 years for a hypothetical woman who survived the age group and was exposed to current ASFRs) in 2017 ranged from 0·08 livebirths (0·07–0·09) in South Korea to 2·4 livebirths (2·2–2·6) in Niger, and the TFR over age 30 years (TFO30; number of livebirths expected for a hypothetical woman ageing from 30 to 54 years who survived the age group and was exposed to current ASFRs) ranged from a low of 0·3 livebirths (0·3–0·4) in Puerto Rico to a high of 3·1 livebirths (3·0–3·2) in Niger. TFO30 was higher than TFU25 in 145 countries and territories in 2017. 33 countries had a negative population growth rate from 2010 to 2017, most of which were located in central, eastern, and western Europe, whereas population growth rates of more than 2·0% were seen in 33 of 46 countries in sub-Saharan Africa. In 2017, less than 65% of the national population was of working age in 12 of 34 high-income countries, and less than 50% of the national population was of working age in Mali, Chad, and Niger. Interpretation: Population trends create demographic dividends and headwinds (ie, economic benefits and detriments) that affect national economies and determine national planning needs. Although TFRs are decreasing, the global population continues to grow as mortality declines, with diverse patterns at the national level and across age groups. To our knowledge, this is the first study to provide transparent and replicable estimates of population and fertility, which can be used to inform decision making and to monitor progress. Funding: Bill & Melinda Gates Foundation.
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