| 1. |
- Alberro-Brage, Andres, et al.
(författare)
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Influenza virus decreases albumin uptake and megalin expression in alveolar epithelial cells
- 2023
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Ingår i: Frontiers in Immunology. - 1664-3224. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- IntroductionAcute respiratory distress syndrome (ARDS) is a common complication of influenza virus (IV) infection. During ARDS, alveolar protein concentrations often reach 40-90% of plasma levels, causing severe impairment of gas exchange and promoting deleterious alveolar remodeling. Protein clearance from the alveolar space is at least in part facilitated by the multi-ligand receptor megalin through clathrin-mediated endocytosis.MethodsTo investigate whether IV infection impairs alveolar protein clearance, we examined albumin uptake and megalin expression in MLE-12 cells and alveolar epithelial cells (AEC) from murine precision-cut lung slices (PCLS) and in vivo, under IV infection conditions by flow cytometry and western blot. Transcriptional levels from AEC and broncho-alveolar lavage (BAL) cells were analyzed in an in-vivo mouse model by RNAseq.ResultsIV significantly downregulated albumin uptake, independently of activation of the TGF- β1/GSK3β axis that has been previously implicated in the regulation of megalin function. Decreased plasma membrane abundance, total protein levels, and mRNA expression of megalin were associated with this phenotype. In IV-infected mice, we identified a significant upregulation of matrix metalloproteinase (MMP)-14 in BAL fluid cells. Furthermore, the inhibition of this protease partially recovered total megalin levels and albumin uptake.DiscussionOur results suggest that the previously described MMP-driven shedding mechanisms are potentially involved in downregulation of megalin cell surface abundance and clearance of excess alveolar protein. As lower alveolar edema protein concentrations are associated with better outcomes in respiratory failure, our findings highlight the therapeutic potential of a timely MMP inhibition in the treatment of IV-induced ARDS.
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| 2. |
- Axelsson, Marie-Louise, et al.
(författare)
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MIND THE GAP! ACADEMIC INFORMATION LITERACY VS WORKFORCE INFORMATION LITERACY
- 2017
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Ingår i: 10TH INTERNATIONAL CONFERENCE OF EDUCATION, RESEARCH AND INNOVATION (ICERI2017). - : IATED-INT ASSOC TECHNOLOGY EDUCATION & DEVELOPMENT. - 9788469769577 ; , s. 1508-1518
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Konferensbidrag (refereegranskat)abstract
- In 2003 Lloyd [1] noted that there ought to be a shift in thinking by librarians and that this requires librarians to develop partnerships with workplace communities so as to understand the role that information plays in the knowledge economy. Furthermore she stated that it was necessary to develop a new language that is relevant to workplace communities and a language that ties information literacy instruction to authentic situations in the workplace. So how can we as librarians prepare students to engage in the variety of information activities that constitute workplace practice today and how can we better tailor our information literacy instruction to meet those needs in the future? One answer could be to gain an understanding on how information competencies are recognized in workplace settings and what kind of information competencies that employers seek. In this pilot study we address the following questions: Does the concept of information literacy or similar appear in British/American and Swedish job ads? What kind of qualifications are most frequent asked for in job postings? What kind of information skills do employers really look for and how does this match with the skills newly recruits have?
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| 3. |
- Brage, Christina, 1950-, et al.
(författare)
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A Re-Conceptualisation of Information Literacy in Accordance with New Social Media Contexts
- 2013
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Ingår i: Proccedings of the 7th International Multi-Conference on Society, Cybernetics and Informatics. - Orlando, Florida : International Institute of Informatics and Systemics. - 9781936338832 ; , s. 217-222
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Konferensbidrag (refereegranskat)abstract
- The aim of this article is to review the need for a re-conceptualisation of Information Literacy in accordance with the development of new social media contexts. A review of the literature indicates that there is a need to take the concept Transliteracy into consideration. Some major challenges like the new information world, digital risky behaviours, democratic challenges and educational challenges will be discussed.
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| 4. |
- Brage, Christina, 1950-, et al.
(författare)
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Applied Information Literacy and Learning : Curriculum Development for the Next Decade
- 2013
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Ingår i: Worldwide Commonalities and Challenges in Information Literacy Research and Practice. - Cham Heidelberg New York Dordrecht London : Springer. - 9783319039183 - 9783319039190 ; , s. 359-365
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Bokkapitel (refereegranskat)abstract
- In 2006 we developed and presented the first version of a model called Applied Information Literacy. The aim of the model was to embed information literacy into research and writing instruction sessions. We tested the model in our information literacy curricula for a couple of years and found it to be too linear. In addition, the information landscape has changed as various forms of social media have become strong players in students’ everyday information world. Therefore there was a need for us to change and simplify our original model, which we present and discuss. According to the students it seems to work well since the new model contributes to their holistic learning resulting in better academic work.
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| 5. |
- Brage, Christina, 1950-
(författare)
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ASSESSING MASTER STUDENTS CITATION BEHAVIOUR BY MINING REFERENCE LISTS IN THESES. : A PILOT STUDY
- 2015
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Ingår i: ICERI2015 Proceedings. 8th International Conference of Education, Research and InnovationSeville, Spain. 18-20 November, 2015. - : IATED-INT ASSOC TECHNOLOGY EDUCATION A& DEVELOPMEN. - 9788460826576 ; , s. 8368-8376
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Konferensbidrag (refereegranskat)abstract
- Entering at a Master’s level means that the student will encounter a level that is more intellectually demanding and more challenging than before. They need to use information sources in various ways and at this stage it is important that they access research and theory-based literature. A primary sign of quality in good research is that it is founded on well proven sources of theory and previous research, and that it utilizes the proper technique of referencing. In order for the students to acquire sufficient search skills, including how to cite and refer, the library offers information literacy training that is timed to happen at the point of need. This requires that they master the research process being able to pose questions and seek answers, to use and apply techniques and research skills, to analyse data, to review literature and write up results in an academic format appropriate to the discipline. According to Carlson (2006, p15), as student’s progress academically, sources cited should demonstrate students' "growing sophistication and ability to think critically in their chosen discipline." But is this really the case? One way to get a sense of this process is to look at what types of sources the graduate students cite in their theses. This study used citation analysis in order to “mine” reference lists obtained from master theses for assessment purposes. The aim of this study is to investigate what kind of information sources master students use in their theses and the author studied the citation patterns in 36 Master's theses.A total of 2173 references were checked and out of them were 886 (40,7%) journal articles. The students used 479 different journals and 378 of them were peer reviewed. 380 (79,3%) journals were kept by the library. 175 (54,6%) book or book chapters were kept by the library out of the 320 used by the students. They also used other sources such as reports of different kind (11,4%), Web pages (0,6%), Grey literature (0,6%) and conference papers (0,2%) to mention a few. Students used 60 references as an average in their theses.Although the accuracy of the citations was beyond the scope of this study, the author noticed a number of problems such as incomplete citations, inconsistent journal title abbreviations and inconsistent use of citation style formats. The author carried out bibliographic searches in order to rectify any incorrect or incomplete citations and this required extra work to correct, but was also indication that we might alter our information literacy training and emphasise more on citing and referencing.Findings indicate that these graduate students surprisingly seems to prefer scholarly journal articles and books or book chapters. The author had anticipated another picture with more references to the Web. This pilot project provided new and important information about the use of collections by master students. The authors learned that the library’s journal coverage is good enough but that the monographic coverage is somewhat less complete. The author will continue to do another study with new theses from 2013-2014 in order to investigate if our new emphasis on citing and referencing had any impact on the inconsistencies that have been seen in the first study and also if the same pattern of information sources used by earlier students occur.References:[1] Carlson, J. (2006), An examination of undergraduate student citation behavior, The Journal of Academic Librarianship 32(1):14-22.
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| 6. |
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| 7. |
- Brage, Christina
(författare)
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BECOMING VISIBLE? ACADEMIC WRITING FOR LIBRARIANS!
- 2017
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Ingår i: 10TH INTERNATIONAL CONFERENCE OF EDUCATION, RESEARCH AND INNOVATION (ICERI2017). - : IATED-INT ASSOC TECHNOLOGY EDUCATION & DEVELOPMENT. - 9788469769577 ; , s. 1503-1507
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Konferensbidrag (refereegranskat)abstract
- There is a "new" trend for us librarians to "articulate our value" such as suggested in Association of College and Research Libraries (ACRL) Value of Academic Libraries initiative [1]. Librarians need to believe that their own distinct contributions have value. As librarians we gather a lot of data but that is not enough anymore. We need to communicate our findings! Although writing for publication is an expected part of the role of faculty staff in most universities but almost no such recognition of the librarian as an academic writer exists.
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| 8. |
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| 9. |
- Brage, Christina, 1950-
(författare)
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Centrum för biblioteks- och IT-pedagogik (CeBIT)
- 2018
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Ingår i: Ett bibliotek i takt med tiden. - Linköping : Linköpings universitetsbibliotek. - 9789176851470 ; , s. 106-112
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- CeBIT startade sin verksamhet den 1 april 2000 som en enhet inom Linköpings universitetsbibliotek (LiUB). Agneta Lantz, Christina Brage och Tommy Carlberg var de som planerade den kommande verksamheten. Agneta kom sedan att bli föreståndare för CeBIT. Under åren som gick växte verksamheten och fick ett positivt gensvar både från studenter och från lärarhåll. Centrets övergripande målsättning var att fungera som ett samlande organ för LiUB:s pedagogiska verksamhet och som en spjutspets för pedagogisk förnyelse och utveckling. Man verkade för att utveckla den egna bibliotekarieprofessionen och förbättra informationskompetensen hos bibliotekets användare. Då kompetensförsörjning troligen är den viktigaste frågan för att säkra kvalitet i en organisation måste det finnas utvecklingsmöjligheter i arbetet för personalen, vilket i högsta grad var ett ledord för CeBIT.Under uppbyggnadsfasen lades krafterna framför allt på att utveckla och genomföra poänggivande kurser, dels inom programmet för Informations- och medievetenskap (IMV), dels fristående. I CeBIT fanns en viktig resurs i arbetet med att höja beredskapen för det livslånga lärandet. Arbetet med att höja studenternas informationskompetens innebar en breddad pedagogisk uppgift för universitetsbiblioteket, vilket i sin tur ställde högre krav på bibliotekariernas pedagogiska kompetens. Detta gällde i alla planerade och oplanerade möten med bibliotekets användare i informations- och lånediskar, per telefon och via e-post liksom i den regelrätta undervisningen i informationssökning. CeBIT kom att kombinera två områden av stort intresse för bibliotekarier – pedagogik och informationskompetens.
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| 10. |
- Brage, Christina, et al.
(författare)
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Collaborative assessment of information literacy education at Linköping University Library
- 2011
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Ingår i: INTED2011 Proceedings, 5th International Technology, Education and Development Conference, Valencia, Spain, 7-9 March, 2011. - : IATED Publications. - 9788461474233 ; , s. 4610-4618
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Konferensbidrag (refereegranskat)abstract
- In this paper we discuss the importance of faculty – librarians working together for the inclusion of information literacy into curriculum in order to prepare students for academic success and future working life.
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