| 1. |
- Engert, Andreas, et al.
(författare)
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The European Hematology Association Roadmap for European Hematology Research : a consensus document
- 2016
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Ingår i: Haematologica. - Pavia, Italy : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 101:2, s. 115-208
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Tidskriftsartikel (refereegranskat)abstract
- The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at (sic)23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.
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| 2. |
- Brand, Ralf, et al.
(författare)
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The ecosystem of expertise : complementary knowledges for sustainable development
- 2007
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Ingår i: Sustainability. - 1548-7733. ; 3:1, s. 21-31
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Tidskriftsartikel (refereegranskat)abstract
- This article critically examines the approach of technical experts, including engineers, natural scientists, architects, planners, and other practitioners, who are attempting to create more sustainable forms of economic development, environmental protection, and social equity. The authors identify four principal characteristics of expertise–ontological assumptions, epistemological approaches, power inequalities, and practical issues–and employ this framework to test the capability of traditional experts to deliver sustainable development. The authors then provide four alternatives to conventional forms of expertise: the outreach expert who communicates effectively to non-experts, the interdisciplinary expert who understands the overlaps of neighboring technical disciplines, the meta-expert who brokers the multiple claims of relevance between different forms of expertise, and the civic expert who engages in democratic discourse with non-experts and experts alike. All of these alternative forms are needed to manage the often-competing demands of sustainable development projects and they can be described collectively as an “ecosystem of expertise.”
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| 3. |
- Gudmundsson, Henrik, et al.
(författare)
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A covenant of halflings? : developing a roadmap for the european urban transport goal
- 2015
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Ingår i: Proceedings of WCTR SIG G3.
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Konferensbidrag (refereegranskat)abstract
- In the 2011 Transport Policy White Paper, the European Commission introduced ten goals for a more competitive and resource efficient transport system. One of the goal concerns urban transport, with the dual targets: “To halve the use of ‘conventionally-fuelled’ cars in urban transport by 2030; and to phase them out by 2050; and “To achieve ‘essentially CO2- free city logistics’ in major urban centres by 2030.” This paper describes how the EU FP7 project TRANSFORUM conducted a stakeholder-driven process to produce a roadmap for the urban transport goal.A main conclusion was that the implementation of a roadmap for urban transport needs to adopt a broad and open approach, given the diversity among member states and cities across Europe. Also it was found that replacing conventional vehicles and fuels is an important but not sufficient strategy to reach the goal. A roadmap to reach towards the ‘halving’ goal would need to engage many cities in shared political commitments to generate a stronger momentum for change. The notion of a ‘Covenant of Halflings’ would be one way to express this need.
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| 4. |
- Gudmundsson, Henrik, et al.
(författare)
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A roadmap for the EU White Paper goal on Urban Transport
- 2015
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Ingår i: Urban Transport XXI. - : WIT Press. - 9781845648985 ; , s. 53-64
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Konferensbidrag (refereegranskat)abstract
- In its 2011 Transport Policy White Paper, the European Commission introduced ten targets to be met in order to reach a more competitive and resource efficient transport system. The following dual goal focused on urban transport and commuting: “To halve the use of ‘conventionally-fuelled’ cars in urban transport by 2030; and to phase them out by 2050; and to achieve “essentially CO2-free city logistics in major urban centres by 2030.” The question driving the research behind this paper is how to realise this dual urban transport goal for 2030, taking into consideration existing trends, available policy options, the diverse interests of stakeholders involved in urban mobility in Europe.The paper draws on data gathered in the EU FP7 TRANSFORuM project, including workshop dialogues with stakeholders representing different interests in and perspectives on urban transport and mobility. The main result is a roadmap that proposes a broad strategy to answer the question “Who has to do what, by when” to achieve the urban transport goal. The roadmap includes detailed proposals for action and milestones at different levels of decision making. This paper will describe the process of consultations and the outcomes of the roadmap process and will also discuss the perspectives for implementation.
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| 5. |
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| 6. |
- Hagger, Martin S., et al.
(författare)
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A Multilab Preregistered Replication of the Ego-Depletion Effect
- 2016
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Ingår i: Perspectives on Psychological Science. - : Sage Publications. - 1745-6916 .- 1745-6924. ; 11:4, s. 546-573
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Tidskriftsartikel (refereegranskat)abstract
- Good self-control has been linked to adaptive outcomes such as better health, cohesive personal relationships, success in the workplace and at school, and less susceptibility to crime and addictions. In contrast, self-control failure is linked to maladaptive outcomes. Understanding the mechanisms by which self-control predicts behavior may assist in promoting better regulation and outcomes. A popular approach to understanding self-control is the strength or resource depletion model. Self-control is conceptualized as a limited resource that becomes depleted after a period of exertion resulting in self-control failure. The model has typically been tested using a sequential-task experimental paradigm, in which people completing an initial self-control task have reduced self-control capacity and poorer performance on a subsequent task, a state known as ego depletion. Although a meta-analysis of ego-depletion experiments found a medium-sized effect, subsequent meta-analyses have questioned the size and existence of the effect and identified instances of possible bias. The analyses served as a catalyst for the current Registered Replication Report of the ego-depletion effect. Multiple laboratories (k = 23, total N = 2,141) conducted replications of a standardized ego-depletion protocol based on a sequential-task paradigm by Sripada et al. Meta-analysis of the studies revealed that the size of the ego-depletion effect was small with 95% confidence intervals (CIs) that encompassed zero (d = 0.04, 95% CI [-0.07, 0.15]. We discuss implications of the findings for the ego-depletion effect and the resource depletion model of self-control.
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| 7. |
- Haridi, Seif, et al.
(författare)
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Efficient logic variables for distributed computing
- 1999
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Ingår i: ACM Transactions on Programming Languages and Systems. - : Association for Computing Machinery (ACM). - 0164-0925 .- 1558-4593. ; 21:3, s. 569-626
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Tidskriftsartikel (refereegranskat)abstract
- We define a practical algorithm for distributed rational tree unification and prove its correctness in both the off-line and on-line cases. We derive the distributed algorithm from a centralized one, showing clearly the trade-offs between local and distributed execution. The algorithm is used to realize logic variables in the Mozart Programming System, which implements the Oz language (see http://www.mozart-oz.org). Oz appears to the programmer as a concurrent object-oriented language with dataflow synchronization Logic variables implement the dataflow behavior. We show that logic variables can easily be added to the more restricted models of Java and ML, thus providing an alternative way to do concurrent programming in these languages. We present common distributed programming idioms in a network-transparent way using logic variables. We show that in common cases the algorithm maintains the same message latency as explicit message passing. In addition, it is able to handle uncommon cases that arise from the properties of latency tolerance and third-party independence. This is evidence that using logic variables in distributed computing is beneficial at both the system and language levels. At the system level, they improve latency tolerance and third-party independence. At the language level, they help make network-transparent distribution practical.
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| 8. |
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| 9. |
- Hedegaard Sørensen, Claus, et al.
(författare)
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The Roadmap to achieve EU goals on urban mobility
- 2015
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Ingår i: Eurotransport. - 1478-8217. ; 13:3, s. 54-57
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Is it possible to change urban mobility in Europe to achieve ambitious sustainability goals? If so, who should do what by when? These questions are answered in a new Roadmap on urban mobility prepared as part of the European FP7 research project TRANSFORuM.
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| 10. |
- Hollestelle, Antoinette, et al.
(författare)
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No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer
- 2016
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Ingår i: Gynecologic Oncology. - : Elsevier BV. - 0090-8258 .- 1095-6859. ; 141:2, s. 386-401
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Tidskriftsartikel (refereegranskat)abstract
- Objective Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3′ UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370. Methods Centralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15,357 ovarian cancer patients; 30,816 controls), the Breast Cancer Association Consortium (33,530 breast cancer patients; 37,640 controls), and the Consortium of Modifiers of BRCA1 and BRCA2 (14,765 BRCA1 and 7904 BRCA2 mutation carriers). Results We found no association with risk of ovarian cancer (OR = 0.99, 95% CI 0.94-1.04, p = 0.74) or breast cancer (OR = 0.98, 95% CI 0.94-1.01, p = 0.19) and results were consistent among mutation carriers (BRCA1, ovarian cancer HR = 1.09, 95% CI 0.97-1.23, p = 0.14, breast cancer HR = 1.04, 95% CI 0.97-1.12, p = 0.27; BRCA2, ovarian cancer HR = 0.89, 95% CI 0.71-1.13, p = 0.34, breast cancer HR = 1.06, 95% CI 0.94-1.19, p = 0.35). Null results were also obtained for associations with overall survival following ovarian cancer (HR = 0.94, 95% CI 0.83-1.07, p = 0.38), breast cancer (HR = 0.96, 95% CI 0.87-1.06, p = 0.38), and all other previously-reported associations. Conclusions rs61764370 is not associated with risk of ovarian or breast cancer nor with clinical outcome for patients with these cancers. Therefore, genotyping this variant has no clinical utility related to the prediction or management of these cancers.
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