| 1. |
- Braniste, Viorica, et al.
(författare)
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The gut microbiota influences blood-brain barrier permeability in mice
- 2014
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Ingår i: Science Translational Medicine. - : American Association for the Advancement of Science. - 1946-6234 .- 1946-6242. ; 6:263, s. 263ra158-
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Tidskriftsartikel (refereegranskat)abstract
- Pivotal to brain development and function is an intact blood-brain barrier (BBB), which acts as a gatekeeper to control the passage and exchange of molecules and nutrients between the circulatory system and the brain parenchyma. The BBB also ensures homeostasis of the central nervous system (CNS). We report that germ-free mice, beginning with intrauterine life, displayed increased BBB permeability compared to pathogen-free mice with a normal gut flora. The increased BBB permeability was maintained in germ-free mice after birth and during adulthood and was associated with reduced expression of the tight junction proteins occludin and claudin-5, which are known to regulate barrier function in endothelial tissues. Exposure of germ-free adult mice to a pathogen-free gut microbiota decreased BBB permeability and up-regulated the expression of tight junction proteins. Our results suggest that gut microbiota-BBB communication is initiated during gestation and propagated throughout life.
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| 2. |
- Ciobanu, V., et al.
(författare)
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Large-Sized Nanocrystalline Ultrathin β-Ga2 O3 Membranes Fabricated by Surface Charge Lithography
- 2022
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Ingår i: Nanomaterials. - : MDPI AG. - 2079-4991. ; 12:4
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Tidskriftsartikel (refereegranskat)abstract
- Large-sized 2D semiconductor materials have gained significant attention for their fascinat-ing properties in various applications. In this work, we demonstrate the fabrication of nanoperforated ultrathin β-Ga2 O3 membranes of a nanoscale thickness. The technological route includes the fabrication of GaN membranes using the Surface Charge Lithography (SCL) approach and subsequent thermal treatment in air at 900◦ C in order to obtain β-Ga2 O3 membranes. The as-grown GaN membranes were discovered to be completely transformed into β-Ga2 O3, with the morphology evolving from a smooth topography to a nanoperforated surface consisting of nanograin structures. The oxidation mechanism of the membrane was investigated under different annealing conditions followed by XPS, AFM, Raman and TEM analyses.
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| 3. |
- Plesco, I, et al.
(författare)
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Photocatalytic degradation of organic dyes using TiO2 nanotube arrays and aero-ZnO-ZnS under UV and visible light illumination
- 2020
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Ingår i: CAS 2020 proceedings. - : IEEE. ; , s. 17-20
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Konferensbidrag (refereegranskat)abstract
- We report on the results of comparative study of the photocatalytic performances of the wide band gap semiconductor catalysts titania (TiO2), zinc oxide (ZnO) and mixed phase of ZnO-ZnS (zinc sulfide). The mixed phase structures show better photodegradation properties under UV and visible light illumination compared to its analogous forms. Rutile phase TiO2 nanotubes showed the highest catalytic activity, resulting in 70% decay of dye concentration within 85 min with visible light irradiation, while the rutile-anatase mixture of TiO2 degrade 75% of the test contaminant within 10 min under UV illumination. Microparticles and assemblies of nanostructures used in the experiments can be recycled effectively and subsequently reused.
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