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Träfflista för sökning "WFRF:(Brenndörfer Erwin Daniel) "

Sökning: WFRF:(Brenndörfer Erwin Daniel)

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1.
  • Brenndörfer, Erwin Daniel, et al. (författare)
  • Hepatitis C virus non-structural 3/4A protein interferes with intrahepatic interferon-γ production.
  • 2012
  • Ingår i: Gut. - : BMJ. - 1468-3288 .- 0017-5749. ; 61:4, s. 589-96
  • Tidskriftsartikel (refereegranskat)abstract
    • The non-structural (NS) 3/4A protease/helicase of the hepatitis C virus is known to modulate signalling pathways in the infected hepatocyte by cleaving CARD adaptor inducing IFNβ (Cardif), T-cell protein tyrosine phosphatase (TC-PTP) and TIR domain-containing adaptor inducing IFNβ (TRIF), but the effects of NS3/4A in vivo still remain unclear.
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2.
  • Einberg, Afrodite Psaros, et al. (författare)
  • Lack of association between interleukin 28B polymorphism and vertical transmission of hepatitis C
  • 2017
  • Ingår i: Journal of Pediatric Gastroenterology and Nutrition - JPGN. - : Lippincott Williams & Wilkins. - 0277-2116 .- 1536-4801. ; 65:6, s. 608-612
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: Single genetic nucleotide polymorphism (rs12979860) near the gene for Interleukin 28B (IL28B), is known to be of importance for frequency of spontaneous clearance and treatment outcome in interferon based therapies in patients with hepatitis C virus (HCV) infection. The aim of this study was to investigate if IL28B polymorphism in children and/or their mothers plays a role in vertical transmission of HCV (HCV-VT).METHODS: Plasma samples from 59 infected women, 76 uninfected children born to infected mothers, and 47 children with known vertically transmitted HCV infection, were analysed for IL28B polymorphism and classified by the IL28B genotype (C/C, C/T and T/T) as well as by viral genotype.RESULTS: The proportion of children with genotype C/C was the same in the vertically infected (36%, 17/47) and the exposed uninfected children (38%, 29/76). No difference was seen when stratifying for viral genotype. There was no association between mothers' IL28B genotype and the risk of vertical transmission.CONCLUSION: Regardless of viral genotype we found no association between IL28B genotype and the risk of HCV-VT. The IL28B genotype CC, which has been shown to be favourable in other settings, was not protective of HCV-VT. Thus, other factors possibly associated with the risk of HCV-VT need to be explored.
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