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- Breznik, Eva, et al.
(författare)
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Effects of distance transform choice in training with boundary loss
- 2021
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Convolutional neural networks are the method of choice for many medical imaging tasks, in particular segmentation. Recently, efforts have been made to include distance measures in the network training, as for example the introduction of boundary loss, calculated via a signed distance transform. Using boundary loss for segmentation can alleviate issues with imbalance and irregular shapes, leading to a better segmentation boundary. It is originally based on the Euclidean distance transform. In this paper we investigate the effects of employing various definitions of distance when using the boundary loss for medical image segmentation. Our results show a promising behaviour in training with non-Euclidean distances, and suggest a possible new use of the boundary loss in segmentation problems.
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- Breznik, Eva
(författare)
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Image Processing and Analysis Methods for Biomedical Applications
- 2023
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- With new technologies and developments medical images can be acquired more quickly and at a larger scale than ever before. However, increased amount of data induces an overhead in the human labour needed for its inspection and analysis. To support clinicians in decision making and enable swifter examinations, computerized methods can be utilized to automate the more time-consuming tasks. For such use, methods need be highly accurate, fast, reliable and interpretable. In this thesis we develop and improve methods for image segmentation, retrieval and statistical analysis, with applications in imaging-based diagnostic pipelines. Individual objects often need to first be extracted/segmented from the image before they can be analysed further. We propose methodological improvements for deep learning-based segmentation methods using distance maps, with the focus on fully-supervised 3D patch-based training and training on 2D slices under point supervision. We show that using a directly interpretable distance prior helps to improve segmentation accuracy and training stability.For histological data in particular, we propose and extensively evaluate a contrastive learning and bag of words-based pipeline for cross-modal image retrieval. The method is able to recover correct matches from the database across modalities and small transformations with improved accuracy compared to the competitors. In addition, we examine a number of methods for multiplicity correction on statistical analyses of correlation using medical images. Evaluation strategies are discussed and anatomy-observing extensions to the methods are developed as a way of directly decreasing the multiplicity issue in an interpretable manner, providing improvements in error control. The methods presented in this thesis were developed with clinical applications in mind and provide a strong base for further developments and future use in medical practice.
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- Breznik, Eva, et al.
(författare)
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Multiple comparison correction methods for whole-body magnetic resonance imaging
- 2020
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Ingår i: Journal of Medical Imaging. - : SPIE-Intl Soc Optical Eng. - 2329-4302 .- 2329-4310. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Voxel-level hypothesis testing on images suffers from test multiplicity. Numerous correction methods exist, mainly applied and evaluated on neuroimaging and synthetic datasets. However, newly developed approaches like Imiomics, using different data and less common analysis types, also require multiplicity correction for more reliable inference. To handle the multiple comparisons in Imiomics, we aim to evaluate correction methods on whole-body MRI and correlation analyses, and to develop techniques specifically suited for the given analyses. Approach: We evaluate the most common familywise error rate (FWER) limiting procedures on whole-body correlation analyses via standard (synthetic no-activation) nominal error rate estimation as well as smaller prior-knowledge based stringency analysis. Their performance is compared to our anatomy-based method extensions. Results: Results show that nonparametric methods behave better for the given analyses. The proposed prior-knowledge based evaluation shows that the devised extensions including anatomical priors can achieve the same power while keeping the FWER closer to the desired rate. Conclusions: Permutation-based approaches perform adequately and can be used within Imiomics. They can be improved by including information on image structure. We expect such method extensions to become even more relevant with new applications and larger datasets.
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- Heil, Raphaela, et al.
(författare)
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A Study of Augmentation Methods for Handwritten Stenography Recognition
- 2023
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Konferensbidrag (refereegranskat)abstract
- One of the factors limiting the performance of handwritten text recognition (HTR) for stenography is the small amount of annotated training data. To alleviate the problem of data scarcity, modern HTR methods often employ data augmentation. However, due to specifics of the stenographic script, such settings may not be directly applicable for stenography recognition. In this work, we study 22 classical augmentation techniques, most of which are commonly used for HTR of other scripts, such as Latin handwriting. Through extensive experiments, we identify a group of augmentations, including for example contained ranges of random rotation, shifts and scaling, that are beneficial to the use case of stenography recognition. Furthermore, a number of augmentation approaches, leading to a decrease in recognition performance, are identified. Our results are supported by statistical hypothesis testing. A link to the source code is provided in the paper.
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- Kundu, Swagata, et al.
(författare)
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ASE-Net for Segmentation of Post-operative Glioblastoma and Patient-specific Fine-tuning for Segmentation Refinement of Follow-up MRI Scans
- 2024
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Ingår i: SN computer science. - : Springer. - 2661-8907. ; 5:106
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Tidskriftsartikel (refereegranskat)abstract
- Volumetric quantification of tumors is usually done manually by radiologists requiring precious medical time and suffering from inter-observer variability. An automatic tool for accurate volume quantification of post-operative glioblastoma would reduce the workload of radiologists and improve the quality of follow-up monitoring and patient care. This paper deals with the 3-D segmentation of post-operative glioblastoma using channel squeeze and excitation based attention gated network (ASE-Net). The proposed deep neural network has a 3-D encoder and decoder based architecture with channel squeeze and excitation (CSE) blocks and attention blocks. The CSE block reduces the dependency on space information and put more emphasize on the channel information. The attention block suppresses the feature maps of irrelevant background and helps highlighting the relevant feature maps. The Uppsala university data set used has post-operative follow-up MRI scans for fifteen patients. A patient specific fine-tuning approach is used to improve the segmentation results for each patient. ASE-Net is also cross-validated with BraTS-2021 data set. The mean dice score of five-fold cross validation results with BraTS-2021 data set for enhanced tumor is 0.8244. The proposed network outperforms the competing networks like U-Net, Attention U-Net and Res U-Net. On the Uppsala University glioblastoma data set, the mean Dice score obtained with the proposed network is 0.7084, Hausdorff Distance-95 is 7.14 and the mean volumetric similarity achieved is 0.8579. With fine-tuning the pre-trained network, the mean dice score improved to 0.7368, Hausdorff Distance-95 decreased to 6.10 and volumetric similarity improved to 0.8736. ASE-Net outperforms the competing networks and can be used for volumetric quantification of post-operative glioblastoma from follow-up MRI scans. The network significantly reduces the probability of over segmentation.
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