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| 3. |
- Semb, G, et al.
(författare)
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Erratum
- 2017
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Ingår i: Journal of plastic surgery and hand surgery. - 2000-6764. ; 51:2, s. 158-158
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Tidskriftsartikel (refereegranskat)
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| 4. |
- MURRAY, JS, et al.
(författare)
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Electrostatic potentials on the molecular-surfaces of cyclic ureides
- 1991
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Ingår i: JOURNAL OF PHYSICAL CHEMISTRY. - : American Chemical Society (ACS). - 0022-3654 .- 1541-5740. ; 95:2, s. 844-848
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Tidskriftsartikel (refereegranskat)abstract
- Ab initio SCF-MO electrostatic potentials have been computed at the STO-5G/STO-3G level on the molecular surfaces of a group of cyclic ureides, in order to assess their relative reactivities toward nucleophiles, as in hydrolysis. The surfaces were defined by the 0.002 electron/bohr3 contour of the molecular electronic density. The relative hydrolytic stabilities within a series of NO2 and NF2 derivatives are predicted, on the basis of the magnitudes of the potentials above the acyl carbons. The surface electrostatic potentials of the polycarbonyl systems parabanic acid and alloxan are shown to be fully consistent with unusually short intermolecular distances that have been observed in crystallographic studies of these compounds.
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| 5. |
- Rizell, Sara, 1963, et al.
(författare)
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Scandcleft randomized trials of primary surgery for unilateral cleft lip and palate: dental anomalies in 8-year olds
- 2020
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Ingår i: European Journal of Orthodontics. - : Oxford University Press (OUP). - 0141-5387 .- 1460-2210. ; 42:1, s. 8-14
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Tidskriftsartikel (refereegranskat)abstract
- Background: Children born with unilateral cleft lip and palate (UCLP) are reported to display several dental anomalies including agenesis, supernumeraries, as well as variations in dental size, shape, and path of eruption. The extensive sample of individuals with UCLP included in the Scandcleft randomized control trials offers the opportunity to study more rare conditions, which is seldom possible with limited samples. Objectives: The aim was to study dental anomalies at 8 years of age in children born with UCLP included in the Scandcleft randomized control trials. Methods: Panoramic and intraoral radiographs from 425 individuals (279 males and 146 females) with a mean age of 8.1 years were assessed by four orthodontists regarding dental anomalies. Results: Agenesis was found in 52.5 per cent and supernumerary teeth in 16.9 per cent of the participants. The cleft lateral was missing in 43.8 per cent and was found peg shaped in 44.7 per cent.The distribution of ectopic eruption was 14.6 per cent, mainly affecting maxillary first molars, while transposition was found in 3.4 per cent of the individuals. In addition, infraocclusion of one or several primary molars was registered in 7.2 per cent of the participants. Conclusion: We conclude that 8-year-old children born with UCLP display multiple dental anomalies. The Scandcleft sample allowed rarely studied conditions such as infraocclusion of primary molars and transposition to be studied in children born with UCLP.
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| 7. |
- Brinck, Tore, et al.
(författare)
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Segmental analysis of molecular surface electrostatic potentials : application to enzyme inhibition
- 2003
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Ingår i: Journal of Molecular Modeling. - : Springer Science and Business Media LLC. - 1610-2940 .- 0948-5023. ; 9:2, s. 77-83
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Tidskriftsartikel (refereegranskat)abstract
- We have recently shown that the anti-HIV activities of reverse transcriptase inhibitors can be related quantitatively to properties of the electrostatic potentials on their molecular surfaces. We now introduce the technique of using only segments of the drug molecules in developing such expressions. If an improved correlation is obtained for a given family of compounds, it would suggest that the segment being used plays a key role in the interaction. We demonstrate the procedure for three groups of drugs, two acting on reverse transcriptase and one on HIV protease. Segmental analysis is found to be definitely beneficial in one case, less markedly so in another, and to have a negative effect in the third. The last result indicates that major portions of the molecular surfaces are involved in the interactions and that the entire molecules need to be considered, in contrast to the first two examples, in which certain segments appear to be of primary importance. This initial exploratory study shows that segmental analysis can provide insight into the nature of the process being investigated, as well as possibly enhancing the predictive capability.
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| 10. |
- Jacobson, A, et al.
(författare)
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Expression of human hyaluronan synthases in response to external stimuli.
- 2000
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Ingår i: Biochemical Journal. - 0264-6021 .- 1470-8728. ; 348 Pt 1, s. 29-35
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Tidskriftsartikel (refereegranskat)abstract
- In the present study we have investigated the expression of mRNAs for hyaluronan synthase isoforms (HAS1, HAS2 and HAS3) in different cells in response to various stimuli. Human mesothelial cells, which synthesize large amounts of hyaluronan, express mRNAs encoding all three HAS isoforms, whereas their transformed counterparts, mesothelioma cells, which produce only minute amounts of hyaluronan, express only HAS3 mRNA. Human lung fibroblasts and the glioma cell line U-118 MG express only the HAS2 and HAS3 genes. The expression of the transcripts was higher in subconfluent than in confluent cultures and was well correlated with the production of hyaluronan by the cells. Stimulation of mesothelial cells with platelet-derived growth factor-BB induced an up-regulation of mRNA for HAS2 to a maximum after 6 h of stimulation; HAS1 and HAS3 genes were only induced slightly. Transforming growth factor-beta1 reduced HAS2 mRNA slightly, and hydrocortisone reduced it strongly, within 6 h of stimulation in mesothelial cell cultures but did not significantly affect the expression of mRNAs for HAS1 and HAS3. Induction of HAS1 and HAS2 protein levels in response to the stimuli above correlated with HAS transcript levels. Thus the expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially regulated by various stimuli suggesting distinct functional roles of the three proteins.
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