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| 2. |
- Arneodo, M, et al.
(författare)
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Accurate measurement of F-2(d)/F-2(p) and R(d)-R(p)
- 1997
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Ingår i: NUCLEAR PHYSICS B. - : ELSEVIER SCIENCE BV. - 0550-3213. ; 487:1-2, s. 3-26
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Tidskriftsartikel (refereegranskat)abstract
- Results are presented for F-2(d)/F-2(p) and R(d) - R(p) from simultaneous measurements of deep inelastic muon scattering on hydrogen and deuterium targets, at 90, 120, 200 and 280 GeV. The difference R(d) - R(p), determined in the range 0.002 < x < 0.4 at
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| 3. |
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| 4. |
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| 5. |
- Arneodo, M, et al.
(författare)
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The A dependence of the nuclear structure function ratios
- 1996
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Ingår i: NUCLEAR PHYSICS B. - : ELSEVIER SCIENCE BV. - 0550-3213. ; 481:1-2, s. 3-22
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Tidskriftsartikel (refereegranskat)abstract
- Results are presented for six nuclei from Be to Pb on the structure function ratios F-2(A)/F-2(C)(X) and their A dependence in deep inelastic muon scattering at 200 GeV incident: muon energy. The data cover the kinematic range 0.01 < x < 0.8 with Q(2) ran
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| 6. |
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| 7. |
- ARNEODO, M, et al.
(författare)
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THE STRUCTURE-FUNCTION RATIOS F-2(LI)/F-2(D) AND F-2(C)/F-2(D) AT SMALL-X
- 1995
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Ingår i: NUCLEAR PHYSICS B. - : ELSEVIER SCIENCE BV. - 0550-3213. ; 441:1-2, s. 12-30
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Tidskriftsartikel (refereegranskat)abstract
- We present the structure function ratios F-2(Li)/F-2(D) and F-2(C)/F-2(D) measured in deep inelastic muon-nucleus scattering at a nominal incident muon energy of 200 GeV. The kinematic range 10(-4) < x < 0.7 and 0.01 < Q(2) < 70 GeV2 is covered. For value
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| 8. |
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| 9. |
- Ghaddar, N, et al.
(författare)
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The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer
- 2021
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 4651-
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Tidskriftsartikel (refereegranskat)abstract
- The integrated stress response (ISR) is an essential stress-support pathway increasingly recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in lung adenocarcinoma (LUAD) development, the most common histological type of lung cancer and a leading cause of cancer death worldwide. Increased phosphorylation of the translation initiation factor eIF2 (p-eIF2α), the focal point of ISR, is related to invasiveness, increased growth, and poor outcome in 928 LUAD patients. Dissection of ISR mechanisms in KRAS-driven lung tumorigenesis in mice demonstrated that p-eIF2α causes the translational repression of dual specificity phosphatase 6 (DUSP6), resulting in increased phosphorylation of the extracellular signal-regulated kinase (p-ERK). Treatments with ISR inhibitors, including a memory-enhancing drug with limited toxicity, provides a suitable therapeutic option for KRAS-driven lung cancer insofar as they substantially reduce tumor growth and prolong mouse survival. Our data provide a rationale for the implementation of ISR-based regimens in LUAD treatment.
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