| 1. |
- Arneodo, M, et al.
(författare)
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Accurate measurement of F-2(d)/F-2(p) and R(d)-R(p)
- 1997
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Ingår i: NUCLEAR PHYSICS B. - : ELSEVIER SCIENCE BV. - 0550-3213. ; 487:1-2, s. 3-26
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Tidskriftsartikel (refereegranskat)abstract
- Results are presented for F-2(d)/F-2(p) and R(d) - R(p) from simultaneous measurements of deep inelastic muon scattering on hydrogen and deuterium targets, at 90, 120, 200 and 280 GeV. The difference R(d) - R(p), determined in the range 0.002 < x < 0.4 at
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| 2. |
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| 3. |
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| 4. |
- Arneodo, M, et al.
(författare)
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The A dependence of the nuclear structure function ratios
- 1996
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Ingår i: NUCLEAR PHYSICS B. - : ELSEVIER SCIENCE BV. - 0550-3213. ; 481:1-2, s. 3-22
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Tidskriftsartikel (refereegranskat)abstract
- Results are presented for six nuclei from Be to Pb on the structure function ratios F-2(A)/F-2(C)(X) and their A dependence in deep inelastic muon scattering at 200 GeV incident: muon energy. The data cover the kinematic range 0.01 < x < 0.8 with Q(2) ran
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| 5. |
- ARNEODO, M, et al.
(författare)
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THE STRUCTURE-FUNCTION RATIOS F-2(LI)/F-2(D) AND F-2(C)/F-2(D) AT SMALL-X
- 1995
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Ingår i: NUCLEAR PHYSICS B. - : ELSEVIER SCIENCE BV. - 0550-3213. ; 441:1-2, s. 12-30
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Tidskriftsartikel (refereegranskat)abstract
- We present the structure function ratios F-2(Li)/F-2(D) and F-2(C)/F-2(D) measured in deep inelastic muon-nucleus scattering at a nominal incident muon energy of 200 GeV. The kinematic range 10(-4) < x < 0.7 and 0.01 < Q(2) < 70 GeV2 is covered. For value
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| 6. |
- AMAUDRUZ, P, et al.
(författare)
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A REEVALUATION OF THE NUCLEAR-STRUCTURE FUNCTION RATIOS FOR D, HE, LI-6, C AND CA
- 1995
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Ingår i: NUCLEAR PHYSICS B. - : ELSEVIER SCIENCE BV. - 0550-3213. ; 441:1-2, s. 3-11
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Tidskriftsartikel (refereegranskat)abstract
- We present a re-evaluation of the structure function ratios F-2(He)/F-2(D), F-2(C)/F-2(D) and F-2(Ca)/F-2(D) measured in deep inelastic muon-nucleus scattering at an incident muon momentum of 200 GeV. We also present the ratios F-2(C)/F-2(Li), F-2(Ca)/F-2
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| 7. |
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| 8. |
- Erba, E, et al.
(författare)
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Effect of Aplidin in acute lymphoblastic leukaemia cells.
- 2003
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Ingår i: British journal of cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 89:4, s. 763-73
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Tidskriftsartikel (refereegranskat)abstract
- The cytotoxic effect of Aplidin was investigated on fresh leukaemia cells derived from children with B-cell-precursor (BCP) acute lymphoblastic leukaemia (ALL) by using stromal-layer culture system and on four cell lines, ALL-PO, Reh, ALL/MIK and TOM-1, derived from patients with ALL with different molecular genetic abnormalities. In ALL cell lines Aplidin was cytotoxic at nanomolar concentrations. In the ALL cell lines the drug-induced cell death was clearly related to the induction of apoptosis and appeared to be p53-independent. Only in ALL-PO 20 nM Aplidin treatment caused a block of vascular endothelial growth factor (VEGF) secretion and downregulation of VEGF-mRNA, but Aplidin cytotoxicity does not seem to be related to VEGF inhibition since the sensitivity of ALL-PO cells to Aplidin is comparable to that observed for the other cells used. Aplidin induced a G(1) and a G(2) M block in ALL cell lines. In patient-derived leukaemia cells, Aplidin induced a strong cytotoxicity evidenced in a stroma-supported immunocytometric assay. Cells from children with genetic abnormalities such as t(9;22) and t(4;11) translocations, associated with an inferior treatment outcome, were sensitive to Aplidin to the same extent as that observed in other BCP-ALL cases. Aplidin exerted a strong cell killing effect (>88%) against primary culture cells from five relapsed ALL cases, at concentrations much lower than those reported to be achieved in plasma of patients receiving Aplidin at recommended doses. Taken together these data suggest that Aplidin could be a new anticancer drug to be investigated in ALL patients resistant to available therapy.
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| 9. |
- Ghaddar, N, et al.
(författare)
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The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer
- 2021
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 4651-
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Tidskriftsartikel (refereegranskat)abstract
- The integrated stress response (ISR) is an essential stress-support pathway increasingly recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in lung adenocarcinoma (LUAD) development, the most common histological type of lung cancer and a leading cause of cancer death worldwide. Increased phosphorylation of the translation initiation factor eIF2 (p-eIF2α), the focal point of ISR, is related to invasiveness, increased growth, and poor outcome in 928 LUAD patients. Dissection of ISR mechanisms in KRAS-driven lung tumorigenesis in mice demonstrated that p-eIF2α causes the translational repression of dual specificity phosphatase 6 (DUSP6), resulting in increased phosphorylation of the extracellular signal-regulated kinase (p-ERK). Treatments with ISR inhibitors, including a memory-enhancing drug with limited toxicity, provides a suitable therapeutic option for KRAS-driven lung cancer insofar as they substantially reduce tumor growth and prolong mouse survival. Our data provide a rationale for the implementation of ISR-based regimens in LUAD treatment.
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| 10. |
- Marta, M., et al.
(författare)
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Precision study of ground state capture in the 14N(p,γ)15O reaction
- 2008
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 78:2
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Tidskriftsartikel (refereegranskat)abstract
- The rate of the hydrogen-burning carbon-nitrogen-oxygen (CNO) cycle is controlled by the slowest process, 14N(p,γ)15O, which proceeds by capture to the ground and several excited states in O15. Previous extrapolations for the ground state contribution disagreed by a factor 2, corresponding to 15% uncertainty in the total astrophysical S factor. At the Laboratory for Underground Nuclear Astrophysics (LUNA) 400 kV accelerator placed deep underground in the Gran Sasso facility in Italy, a new experiment on ground state capture has been carried out at 317.8, 334.4, and 353.3 keV center-of-mass energy. Systematic corrections have been reduced considerably with respect to previous studies by using a Clover detector and by adopting a relative analysis. The previous discrepancy has been resolved, and ground state capture no longer dominates the uncertainty of the total S factor. © 2008 The American Physical Society.
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